The role of filaggrin gene (FLG) in patients with atopic dermatitis in Al-Najaf Governorate, Iraq

Abstract

This study sought to detect the role of filaggrin gene (FLG) in patients which play a role in the disease or development of atopic dermatitis. for a period of 16 months, from 1/5/2022 to 1/8/2023, the (100) samples in this study were divided into two groups: the patients (70), whose clinical diagnosis of atopic dermatitis (AD) is confirmed by dermatologists, and the control groups (30), whose immunological and biochemical analyses confirmed their status. Patients and controls were arranged according to age and gender, with age groups further divided into five categories: 1-7, 7-16, 16-33, 33-45, and >45 years. The samples were analyzed by DNA sequencing for filaggrin gene. The results showed the filaggrin gene there were no significant difference between ,patients and healthy groups at (Pvalue =0.081) and there were no significant difference between male and female (P-value =0.143) and Highly significant difference at (P-value ≤0.001) Genetic sequencing of the FLG gene was observed with three genotypes (CC, CT, and TT).