The role of fine-needle aspiration in the diagnosis of thyroid lymphoma: a retrospective study of nine cases and review of published series

Morgen, Eric; Geddie, William R.; Boerner, Scott; Bailey, Denis; Santos, Gilda da Cunha

doi:10.1136/jcp.2009.071423

Cited by 37 publications

(32 citation statements)

References 26 publications

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“…To our knowledge, only few articles have reported the systematic use of FC in detecting TL (11,(19)(20)(21)(22). In this study, FC was utilized together with FNAC to improve the detection of lymphomas among lymphoid infiltration of the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Utilility of flow cytometry as ancillary study to improve the cytologic diagnosis of thyroid lymphomas

et al. 2014

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Results: A final diagnosis of lymphoma was given in 13 of 35 (37.1%) specimens. Among the 22 cases considered negative for lymphoma by FC, 11 were diagnosed as thyroiditis by cytology, 7 as reactive, 2 were anaplastic carcinoma, and 2 cases were considered cytologically suspicious for lymphoma but were not confirmed by further investigations. Histology on core biopsy or molecular analysis was available in 12 of 13 lymphoma cases (92.3%). Data obtained by the combination cytology/FC were confirmed in all cases on histology biopsies. Correlation with histology showed a sensitivity and a specificity of 100% for the combination cytology/FC. Conclusions: FC is an important additional test that can contribute with cytology to the identification of lymphomas of the thyroid. FC can detect the presence of small neoplastic lymphocyte populations and may contribute to the diagnosis of cases in which the lymphoid infiltrate is difficult to interpret on cytology alone. V C 2014 International Clinical Cytometry Society

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Section: Discussionmentioning

confidence: 99%

Utilility of flow cytometry as ancillary study to improve the cytologic diagnosis of thyroid lymphomas

et al. 2014

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“…4,5 Moreover, FAN is heavily dependent on the technical excellence and the experience of the operators. Recently, the diagnosis of thyroid carcinoma through potential biomarkers has drawn attention.…”

Section: Introductionmentioning

confidence: 99%

Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter

Yao

Yin

et al. 2011

Mol. BioSyst.

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Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. In the present study, a metabonomic investigation based on liquid chromatography-LTQ Orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (PTC), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. According to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. It was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with clinical features. The major metabolic differences between benign and malignant nodules occurred in lipid metabolism. Especially, the content of 3-hydroxybutyric acid, an intermediate product of fatty acid metabolism, was much higher in the PTC group than that in the nodule goiter and control groups, indicating its potential as a diagnostic marker for PTC and nodular goiters. These results show that the serum metabolic profiling method is a powerful tool for distinguishing thyroid carcinoma from nodular goiter and healthy controls.

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“…The development of MALT lymphoma from Hashimoto's thyroiditis takes a long time, sometimes as long as 30 years. MALT lymphoma is generally characterized by an indolent clinical course, although transformation from MALT lymphoma to aggressive lymphoma may occur in some cases [8].…”

Section: Review Of Literaturementioning

confidence: 99%

Proper Management of Rapidly Growing Large B-Cell Primary Thyroid Lymphoma, Case Report and Review of Literature

Hafez¹,

Nason²

2017

Thyroid Disorders Ther

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The role of fine-needle aspiration in the diagnosis of thyroid lymphoma: a retrospective study of nine cases and review of published series

Cited by 37 publications

References 26 publications

Utilility of flow cytometry as ancillary study to improve the cytologic diagnosis of thyroid lymphomas

Utilility of flow cytometry as ancillary study to improve the cytologic diagnosis of thyroid lymphomas

Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter

Proper Management of Rapidly Growing Large B-Cell Primary Thyroid Lymphoma, Case Report and Review of Literature

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