The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions

Inohara, Hidenori; Akahani, Shiro; Yamamoto, Yoshihiko; Hattori, Kenji; Tomiyama, Yoichiro; Tomita, Yoshihiro; Aozasa, Katsuyuki; Kubo, Takeshi

doi:10.1080/00016480701827533

Cited by 52 publications

(47 citation statements)

References 16 publications

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“…It was later identified as the ligand for Gal-3 in the search for novel ligands for Gal-3 by Inohara et al (22). The cDNA for Gal-3BP codes for a 567-amino acid that is preceded by an 18-amino acid leader peptide.…”

Section: Discussionmentioning

confidence: 99%

“…It is expressed in numerous cancer cells including non-small cell lung cancer, astrocytoma, and colon cancer and is a predictor of poor survival (25)(26)(27). Gal-3BP binds to multiple proteins of the extracellular matrix like collagens, fibronectin and nidogen (20), and to molecules mediating cell-matrix and cell-cell adhesions that are critical during tumor cell invasion and migration (22). Gal-3BP is also a regulator of the immune system.…”

Section: Discussionmentioning

confidence: 99%

“…at the cell membrane but also in the cytoplasm and the nucleus of cells (21,22). We, therefore, determined whether Gal-3 was expressed by BMSC (Fig.…”

Section: Table 2 Soluble Proteins Separated By Molecular Sieve Chromamentioning

confidence: 99%

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Identification of Galectin-3-binding Protein as a Factor Secreted by Tumor Cells That Stimulates Interleukin-6 Expression in the Bone Marrow Stroma

Fukaya

Shimada

Wang

et al. 2008

Journal of Biological Chemistry

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We have previously demonstrated that neuroblastoma cells increase the expression of interleukin-6 by bone marrow stromal cells and that stimulation does not require cell-cell contact. In this study we report the purification and identification of a protein secreted by neuroblastoma cells that stimulates interleukin-6 production by stromal cells. Using a series of chromatographic purification steps including heparin-affinity, ion exchange, and molecular sieve chromatography followed by trypsin digestion and liquid chromatography tandem mass spectrometry, we identified in serum-free conditioned medium of neuroblastoma cells several secreted peptides including galectin-3-binding protein, also known as 90-kDa Mac-2-binding protein. We demonstrated the presence of the galectin-3-binding protein in the conditioned medium of several neuroblastoma cell lines and in chromatographic fractions with interleukin-6 stimulatory activity. Consistently, bone marrow stromal cells express galectin-3, the receptor for galectin-3-binding protein. Supporting a role for galectin-3-binding protein in stimulating interleukin-6 expression in bone marrow stromal cells, we observed that recombinant galectin-3-binding protein stimulated interleukin-6 expression in these cells and that interleukin-6 stimulation by neuroblastoma-conditioned medium was inhibited in the presence of lactose or a neutralizing anti-galectin-3 antibody. Down-regulation of galectin-3-binding protein expression in neuroblastoma cells also decreased the interleukin-6 stimulatory activity of the conditioned medium on bone marrow stromal cells. We also provide evidence that stimulation of interleukin-6 by galectin-3-binding protein involves activation of the Erk1/2 pathway. The data, thus, identifies galectin-3-binding protein as a factor secreted by neuroblastoma cells that stimulates the expression of interleukin-6 in bone marrow stromal cells and provides a novel function for this protein in cancer progression.It has become increasingly evident that the tumor microenvironment plays an important contributory role to cancer progression (1). Tumor cells closely interact with non-malignant cells present in the tumor stoma through a series of adhesiondependent and adhesion-independent mechanisms. Among the adhesion-independent interactions, cytokines, chemokines, and growth factors play a critical role (2, 3). In this regard, the bone marrow, which is a frequent site of metastasis, provides a microenvironment that is particularly favorable to cancer progression because it is a source of hematopoietic and mesenchymal cells that produce a large number of cytokines and chemokines (4 -6).Neuroblastoma is a neural crest-derived cancer that is the second most common solid tumor in children (7). At the time it is diagnosed, it has metastasized in 56% of the cases, primarily to the bone marrow, the bone, and the liver (8). The mechanisms by which neuroblastoma cells invade the bone have been recently elucidated by several laboratories, including our group (9 -11). We have previou...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Identification of Galectin-3-binding Protein as a Factor Secreted by Tumor Cells That Stimulates Interleukin-6 Expression in the Bone Marrow Stroma

Fukaya

Shimada

Wang

et al. 2008

Journal of Biological Chemistry

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“…On the other hand, the sensitivity of conventional MRI in predicting malignancy is known to be quite low. [5][6][7] Several researchers reported that time-signal intensity curves (TICs) obtained by dynamic contrast-enhanced MRI (DCE-MRI) were useful in the differential diagnosis of salivary gland tumours and that the TIC characterized by early enhancement and low washout was associated with malignancy. 4,[8][9][10][11][12][13][14][15] However, the specific criteria involved, that is, the definition of and thresholds for the time to peak enhancement and the washout ratio (WR), have varied widely among studies.…”

Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 99%

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Lam¹,

Kuribayashi²,

Imaizumi³

et al. 2015

BJR

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The authors Phong Dai Lam and Ami Kuribayashi equally contributed to this work.Objective: To determine the optimal diagnostic criterion of dynamic contrast-enhanced MRI (DCE-MRI) for predicting salivary gland malignancy using a dynamic sequence with high temporal resolution, as well as the accuracy of this technique. Methods: The DCE-MRI findings of 98 salivary gland tumours (74 benign and 24 malignant) were reviewed. MR images were sequentially obtained at 5-s intervals for 370 s. Two parameters, peak time and washout ratio (WR) were determined from the time-signal intensity curve. The optimal thresholds of these parameters for differentiating benign and malignant tumours were determined, along with the diagnostic accuracy of the criterion using these thresholds. Results: A peak time of 150 s and a WR of 30% were identified as optimal thresholds. As the criterion for malignancy, the combination of peak time ,150 s and WR ,30% provided a sensitivity of 79% (19/24), specificity of 95% (70/74) and an overall accuracy of 91% (89/98). Three of the five false-negative cases were malignant lymphomas of the parotid gland. Conclusion: Peak time ,150 s with WR ,30% comprised the optimal diagnostic criterion in predicting salivary gland malignancy, providing a sensitivity of 79% and specificity of 95%. The use of high temporal resolution might improve the accuracy of DCE-MRI. Advances in knowledge: Although several studies have reported the usefulness of DCE-MRI in the differential diagnosis of salivary gland tumours, the specific diagnostic criteria employed have differed widely. We determined the optimal criterion and its accuracy using a dynamic sequence with high temporal resolution.

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“…The diagnostic value of pre-operative MRI and FNAC was considered to be a maximum of 80% in terms of sensitivity and specificity. 14,15 In fact, the FNAC performed for our case diagnosed the patients pre-operatively with a mucoepidermoid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

A case of cystadenocarcinoma of the ectopic salivary gland: comparison of pre-operative ultrasound, CT and MR images with the pathological specimen

Enomoto

Yamashita²,

Harada³

et al. 2012

Dentomaxillofacial Radiology

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Cystadenocarcinoma is a rare salivary gland tumour. Only a few case studies have provided pre-operative images of these tumours. This report demonstrates the case of a 28-year-old male with cystadenocarcinoma arising from an ectopic salivary gland with lymph node metastasis in the right upper neck. Ultrasound including Doppler images showed two masses with scant vascular flow. One was a hyperechoic mass enclosed within a low echoic cystic lesion and the other was a solid hypoechoic mass. Contrast enhancement CT scans demonstrated a ring enhanced mass and weakly homogeneous enhanced masses in the right upper neck. Dynamic studies showed increased enhancement in delayed phase CT that was the same as that in other malignant salivary gland tumours. Moderate to slightly high signal intensity was seen on T 1 weighted MR images and axial T 2 weighted MR images showed one heterogeneous mass in a high signal lesion and a moderate to high signal intensity mass. The authors discuss the pre-operative findings of ultrasound with Doppler imaging of this neoplasm, and CT findings including dynamic study images and MRI, comparing the findings with the post-operative pathological features of the tumour.

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The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions

Cited by 52 publications

References 16 publications

Identification of Galectin-3-binding Protein as a Factor Secreted by Tumor Cells That Stimulates Interleukin-6 Expression in the Bone Marrow Stroma

Identification of Galectin-3-binding Protein as a Factor Secreted by Tumor Cells That Stimulates Interleukin-6 Expression in the Bone Marrow Stroma

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

A case of cystadenocarcinoma of the ectopic salivary gland: comparison of pre-operative ultrasound, CT and MR images with the pathological specimen

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