The role of flexible bronchoscopy in children with Mycoplasma pneumoniae pneumonia

Wang, Lijun; Xie, Qiuling; Xu, Shanshan; Li, Huajun; Zhang, Liya; Ai, Jingwen; Liu, Quanhua; Chu, Caiting; Zhang, Xi; Zhang, Wenhong; Huang, Lisu

doi:10.1038/s41390-021-01874-z

Cited by 19 publications

(17 citation statements)

References 32 publications

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“…The mean age of the children group was 6.3 ± 3.9 years, which is consistent with previous reports [ 11 ]. The caregivers had an average age of 35.1 ± 4.6 years, and most of them were female.…”

Section: Discussionsupporting

confidence: 92%

“…Monitoring the fever pattern in children is crucial for assessing the disease progression and outcome [ 13 ]. Previous studies showed that children with MP had a fever lasting 7–10 days [ 11 , 14 ]. However, our patients with familial MP infection had a shorter fever duration than those reported in the literature, which was consistent with the lower proportion of lung consolidation in our cohort.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections

Liu,

Zhang,

Chen

et al. 2024

BMC Pulm Med

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Background Mycoplasma pneumoniae infections have increased in China recently, causing some evidence of familial clustering. The purpose of this study was to compare the clinical features of parents and children in cases of familial clustering of Mycoplasma pneumoniae infection. Methods A retrospective analysis was performed on the cases of familial clustering of Mycoplasma pneumoniae infection, and the clinical characteristics of parents and children were compared. Results We identified 63 families, of these, 57 (65.5%) adults and 65 (94.2%) children required hospitalization. Fifty-seven adults (mean age 35.1 ± 4.6 years, 80.7% female) and 55 children (mean age 6.3 ± 3.9 years, 54.5% female) were included in the analysis. The incidence of mycoplasma infection in adults had increased gradually over the past year, while the rate in children had spiked sharply since June 2023. The clinical symptoms were similar in the two groups, mainly fever and cough. The peak temperature of children was higher than that of adults (39.1 ± 0.7℃ vs 38.6 ± 0.7℃, p = 0.004). Elevated lactate dehydrogenase was more common in children than in adults (77.8% vs 11.3%, p < 0.001). Bronchial pneumonia and bilateral involvement were more common in children, while adults usually had unilateral involvement. Three (60%) adults and 21 (52.5%) children were macrolide-resistant Mycoplasma pneumoniae infected. Children were more likely to be co-infected (65.5% vs 22.8%, p < .001). Macrolides were used in most children and quinolones were used in most adults. Ten (18.2%) children were diagnosed with severe Mycoplasma pneumoniae pneumonia, whereas all adults had mild disease. Children had a significantly longer fever duration than adults ((5.6 ± 2.2) days vs (4.1 ± 2.2) days, p = 0.002). No patient required mechanical ventilation or died. Conclusions Mycoplasma pneumoniae infection shows a familial clustering epidemic trend at the turn of summer and autumn, with different clinical characteristics between parents and children.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections

Liu,

Zhang,

Chen

et al. 2024

BMC Pulm Med

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“…BAL can improve pulmonary imaging of RMPP patients and shorten hospitalization time ( 20 , 28 ). However, some clinical studies have shown that BAL can significantly prolong the hospital stay and increase the total cost ( 21 ). Why the contradictory results?…”

Section: Discussionmentioning

confidence: 99%

“…In combination with medication, BAL gets a better treatment than medication alone in children with RMPP ( 20 ). Clinical studies have shown that BAL can improve the recovery of lung injury in MPP patients with multipolar consolidation ( 21 ). The improvement of BAL in the initial stage of MPP is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Zhang

Wang

et al. 2023

Front. Pediatr.

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BackgroundThe purpose of this study was to evaluate the efficacy and safety of BAL in treating MPP.MethodsFrom January 2013 to January 2019, 1,689 pediatric patients with MPP were analyzed retrospectively. Patients were subdivided into BAL group and non-BAL group according to whether they received BAL treatment within seven days after admission. The propensity score matching method matched patients' baseline characteristics (1:1). The primary outcomes were hospital stays and the cure rate. Secondary outcomes included mortality, co-infection, repeat hospitalization within 30 days, and total cost of treatment.ResultsAfter matching, 524 patients (BAL: 262; control: 262) were recorded. The BAL group had significantly shorter hospital stays (OR: 0.5, 95% CI: 0.4–0.7). Meanwhile, BAL did not significantly modify the cost, co-infection rate, and mortality. In subgroup analyses, the group with BAL intervention within three days had a significantly shorter hospital stay (OR: 0.4, 95% CI: 0.3–0.5) compared with the group with BAL intervention three days after admission.ConclusionsEarly BAL intervention is a better treatment than conventional drug therapy alone, and no significant complications were seen in this study. BAL intervention has an excellent clinical benefit. The earlier the intervention, the better the effect.

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“…In severe mycoplasma pneumoniae pneumonia, about 24.9% patients were accompanied with lung consolidation. Fiberoptic bronchoscopy and bronchoalveolar lavage therapy can help detecting mycoplasma pneumoniae pneumonia pathogen in time, with detecting infection, locating sputum plug and inflammatory polyps, and improving consolidation 2 . However, a real‐time bedside tool for evaluating the effectiveness of bronchoalveolar lavage in PICU was still missing.…”

Section: Figurementioning

confidence: 99%

Bronchoalveolar lavage improved ventilation/perfusion matching in pediatric severe mycoplasma pneumoniae pneumonia with lung consolidation

Tang

Ren

Qian

et al. 2022

Pediatric Pulmonology

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The role of flexible bronchoscopy in children with Mycoplasma pneumoniae pneumonia

Cited by 19 publications

References 32 publications

Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections

Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Bronchoalveolar lavage improved ventilation/perfusion matching in pediatric severe mycoplasma pneumoniae pneumonia with lung consolidation

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