The Role of Fluoride in the Prevention of Tooth Decay

Pollick, Howard

doi:10.1016/j.pcl.2018.05.014

Cited by 110 publications

(79 citation statements)

References 31 publications

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“…Much of the physiological behavior of fluoride (for example, its absorption, distribution and renal clearance) is due to the diffusion of HF [2] . The ingestion of fluoride during the pre-eruptive development of the teeth has a cariostatic effect due to the uptake of fluoride by enamel crystallites and formation of fluor-hydroxy-apatite, which is less acid soluble than hydroxyapatite [3,4] .…”

Section: Introductionmentioning

confidence: 99%

The Possible Protective Role of Methionine against Sodium Fluoride-Induced Pancreatic Changes in the Adult Male Albino Rat: A Histological, Immunohistochemical and Morphometric Study

Zaghloul

Gad-Elrab

Bushra

et al. 2019

Egyptian Journal of Histology

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Background: Excess fluorides intake produces histopathological changes of many organs. Methionine is a potential natural antioxidant against oxidative radicals. Aim of the Work: To evaluate the possible protective role of methionine against sodium fluoride (NaF)-induced pancreatic toxicity. Material and Methods: Thirty 3-months (200-250gm) adult male albino rats were divided into three equal groups: group I (control), group II (Fluoride group) and group III (Fluoride+methionine group). Control group; was given 1ml distilled water. Fluoride group; was given 10 mg NaF/kg b.w. Fluoride+methionine group; was given 10 mg NaF/kg b.w. and 2 mg methionine/rat. All the treatment was given orally by gastric tube once daily for 35 days. After anesthesia, all groups were sacrificed. The pancreatic specimens were prepared for light and electron microscopic studies and anti-insulin antibody immunohistochemical staining. The mean numbers of zymogen granules and insulin positive β-cells of all groups were counted. Results: The mean numbers of zymogen granules and insulin positive β-cells of the fluoride group were significantly decreased when compared to control. The pancreatic specimens of the fluoride group revealed congested blood vessels, extravasated blood cells, vacuolated pancreatic acini, loss of the acinar cell architecture, dilated rough endoplasmic reticulum and degenerated mitochondria. By anti-insulin antibodies immunohistochemistry, there was a weak positive reactivity in the fluoride treated group when compared to control. The concomitant administration of NaF and methionine improved these changes. Conclusion: The concurrent administration of NaF and methionine ameliorates the structural alterations developed in the pancreas following excess NaF intake.

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Section: Introductionmentioning

confidence: 99%

The Possible Protective Role of Methionine against Sodium Fluoride-Induced Pancreatic Changes in the Adult Male Albino Rat: A Histological, Immunohistochemical and Morphometric Study

Zaghloul

Gad-Elrab

Bushra

et al. 2019

Egyptian Journal of Histology

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“…One of the oral hygiene measures to control these microorganisms is the use of toothpaste, as it contains antimicrobial agents such as fluoride and others. 21 The present study found that Aquafresh My Little Teeth is the toothpaste with the lowest inhibitory effect, possibly because it does not contain extra antimicrobial substances such as xylitol, containing only fluoride in the form of sodium fluoride.…”

Section: Discussionmentioning

confidence: 56%

In vitro efficacy of five pediatric toothpastes in the inhibition of Streptococcus mutans ATCC 25175

Miñano

Espinoza-Salcedo

2020

J Oral Res

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The present in vitro study compared the inhibitory action of five pediatric toothpastes against Streptococcus mutans ATCC 25175. Materials and Methods: Cross-sectional, comparative and experimental study. The microorganism Streptococcus mutans ATCC 25175 was inoculated onto solid culture medium of Müeller-Hinton supplemented with blood, then the plates were inoculated with five pediatric toothpastes: Oral B Stages, Colgate Smiles, Aquafresh My Little Teeth, Dentito and Denture Kids. Samples were incubated at 37°C for 48 hours. Subsequently the inhibition halos were measured; the experiment was repeated 20 times for each sample. Statistical analysis was performed with ANOVA complemented with Tukey's test. Results: Oral B Stages yielded a mean inhibitory halo of 23.2mm, Colgate Smiles an average of 21.7mm, Aquafresh My Little Teeth of 13.6mm, Dentito of 18.5mm, and Denture Kids a mean of 23.0mm. When performing the ANOVA test, it was found that there was a significant difference in the inhibitory action of pediatric toothpastes (p<0.005) and when using Tukey's multiple comparison test, Oral B and Denture Kids presented similar inhibitory action. Conclusion: All toothpastes presented inhibitory action against Streptococcus mutans ATCC 25175. A significant difference between their effectiveness was observed. Oral B Stages showed the greatest degree of inhibition.

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“…11 The use of fluoride toothpaste and mouth rinse can be carried out by children's parents or by themselves as an individual measure. 12 Toothbrushing is usually carried out using a manual or powered toothbrush and a fluoride toothpaste for 2 min two times a day. 2 Systematic reviews have shown that only toothpastes with fluoride concentrations of at least 1000 ppm can prevent caries effectively.…”

Section: Description Of the Interventionmentioning

confidence: 99%

Is it necessary for children to receive professional fluoride in addition to regular fluoride toothpaste? Protocol for a systematic review

et al. 2020

BMJ Open

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IntroductionRegular toothbrushing with fluoride toothpaste is a fundamental intervention for caries prevention. Professional fluoride application (PFA) is widely considered a beneficial supplement to the routine use of fluoride toothpaste. However, some recent studies have failed to demonstrate the preventive effect of PFA. In addition, an increasing number of studies have highlighted the potential adverse effects of fluoride. However, little information exists on the effectiveness of additional PFA. The objective of this review is to systematically analyse the efficacy of PFA in addition to regular fluoride toothpaste among children under the age of 16.Method and analysisWe will search the PubMed, Embase, Google Scholar and Cochrane Central Register of Controlled Trials databases for randomised controlled trials without language or publication date restrictions. Additional studies will be identified by manually searching the reference lists of the included studies and relevant reviews. At least two authors will carry out the selection of studies independently and in duplicate. The Cochrane Risk of Bias tool will be used to assess the risk of bias of the included studies. The random effects model will be used for meta-analyses. The data synthesis will be conducted using Review Manager software (RevMan V.5.3). The Grading of Recommendation, Assessment, Development and Evaluation will be used to assess the quality of supporting evidence for each major comparison.Ethics and disseminationThere is no need for ethical approval. The results of this review will be disseminated through peer-reviewed publications and social networks.PROSPERO registration numberCRD42020165270

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The Role of Fluoride in the Prevention of Tooth Decay

Cited by 110 publications

References 31 publications

The Possible Protective Role of Methionine against Sodium Fluoride-Induced Pancreatic Changes in the Adult Male Albino Rat: A Histological, Immunohistochemical and Morphometric Study

The Possible Protective Role of Methionine against Sodium Fluoride-Induced Pancreatic Changes in the Adult Male Albino Rat: A Histological, Immunohistochemical and Morphometric Study

In vitro efficacy of five pediatric toothpastes in the inhibition of Streptococcus mutans ATCC 25175

Is it necessary for children to receive professional fluoride in addition to regular fluoride toothpaste? Protocol for a systematic review

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