The Role of FNAC in Diagnosis of Breast Disease at Different Ages - 208 Cases

Chaudhury, Sudipto; Alam, Khurshid; Haque, Sabrina

doi:10.3329/jbcps.v30i3.12462

Cited by 3 publications

(3 citation statements)

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“…Our finding is concordant with Jayaram G et al [4] and PB Jarwani et al [5] who also found inadequate samples to be 7.43% and 4.5% respectively. In our study, maximum number of cases was in 20-29 years which is in concordance with the result of the studies by Modi P et al, al [6] Singh A et al, [7] Chaudhury S et al, [8] Likhar KS et al, [9] Thakkar B et al [10] Maximum number of benign cases was in the age group of 20-29 years which is near similar to the findings of Modi P et al, [6] Likhar KS et al, [9] Rahman MZ et al [11] and Thakkar B et al [10] Maximum number of malignant cases fell between 50-59 years. Our finding are in concordance with studies of A Singh et al, [7] Bukhari MH et al, [12] Chaudhury S et al, [8] Likhar KS et al [9] while slightly lower age group of 41-50yrs was noted by Thakkar B et al [10] In our study, 83% cases were benign which is close to the finding of Chaudhury S et al [8] (80.77%) while Modi P et al, [6] Bukhari MH et al, [12] Thakkar B et al [10] found lower percentage of benign cases i.e.…”

Section: Discussionsupporting

confidence: 92%

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A Study of Myoepithelial Cells in Fine Needle Aspirates from Breast Lump Using Antibody to p63

Agarwal

Prakash²,

Bhadhkaria³

et al. 2017

APALM

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Background: Myoepithelial cells of the mammary gland are considered to be a key in distinguishing benign from malignant disease in fine-needle aspiration cytology (FNAC). p63 decorates the nuclei of myoepithelial cells. In view of this, present study was undertaken to study the difference in number of myoepitheal cells in various breast lesions using anti p63 immunocytochemistry. Methods: This study was conducted on 50 patients presenting with breast lump. FNA was done, smears prepared were stained with May Grunwald Giemsa and subjected to immunocytochemistry for p63. MGG stained smears were subjected to quantitative estimation of myoepithelial cells per 1000 ductal cells. Percentage of cell clusters showing p63 positive cells were noted. Only the nuclear immunoreactivity for p63 was considered specific. Result: Maximum number of cases (26) were in 20-29 years age group (55.3%).The mean number of myoepithelial cells in the benign lesions was 196.8 while ductal carcinoma had a mean of 5.8.The difference between the mean of myoepithelial cells/1000 ductal cells was found to be statistically significant (t-value 4.51 and p-value .000048). The difference in p63 immunostaining between benign and malignant lesions was also found to be statistically significant (for positivity of p63 at 0% and > 75% p value <0.001). Conclusion: We hereby conclude that myoepithelial cells are a key to distinguish benign from malignant lesions in FNAC. Their sensitivity is increased by staining with p-63 antibody. We also conclude that presence of more than 74% positive cell clusters is strongly suggestive of benign lesions.

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Section: Discussionsupporting

confidence: 92%

“…Our study did not include these categories. In our study 17% cases were malignant which is near similar to the findings of Modi P et al, [6] Chaudhury S et al, [8] Rahman MZ et al [11] as their reported rates of malignancy were 16.7%, 19.23% and 14.17% respectively.…”

Section: Discussionsupporting

confidence: 90%

A Study of Myoepithelial Cells in Fine Needle Aspirates from Breast Lump Using Antibody to p63

Agarwal

Prakash²,

Bhadhkaria³

et al. 2017

APALM

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“…[12][13][14] In the present study, 32.4% cases were malignant which is much higher than the findings of Modi P et al, Chaudhary S et al and Rahman MZ et al, as their results were 16.7%, 19.23% and 14.7% respectively. 12,15,16 Fibroadenoma accounted for 49.3% of all the breast lumps in our study. Our finding was in agreement with most of the available literature on benign breast lumps, where the frequency of fibroadenoma ranged from 46.6%-55.6%.…”

Section: Discussionmentioning

confidence: 61%

Role of p63 expression in non-proliferative and proliferative lesions of breast

et al. 2018

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Background: Breast lump among females, is a fairly common complaint. Breast lump have a variety of etiologies ranging from inflammatory to benign to malignant lesions. Myoepithelial markers are useful in helping to distinguish invasive carcinoma from benign proliferations with a similar morphological appearance, benign proliferative lesions and most pre-invasive lesions with an intact myoepithelium. Invasive carcinomas lack the myoepithelial cell layer that normally surrounds benign breast glands. p63 antibody is a myoepithelial cell marker that selectively stains nuclei. Also, it is negative in stromal, myofibroblastic and adipocytic cells. This makes p63 more specific and superior to other myoepithelial markers.Methods: The present study was done on a total of 151 cases of breast diseases, received in the form of core biopsy, tru cut biopsy, lumpectomy, and mastectomy specimens. Clinical history and examination findings of the patients were collected in all the cases. All specimens were routinely processed and stained with haematoxylin and Eosin (H and E) stain and only 50 cases were subjected to immunohistochemical staining for p63.Results: Out of total 151 cases, 09 were inadequate for evaluation, 96 cases benign and 46 malignant. In benign category, fibroadenoma was most common and infiltrating ductal carcinoma (NOS) was the most common in malignant category. Mean size of benign tumors was found to be less than that of malignant tumors. All malignant cases were negative for p63 expression. In the benign category, 88.6% cases showed positive expression for p63 while 11.4% were negative. Among the benign category, non-proliferative lesions were continuous positive, proliferative showed discontinuous positivity for p63.Conclusions: Myoepithelial markers are useful in helping to distinguish invasive carcinoma from benign proliferations with a similar morphological appearance, benign proliferative lesions and most pre-invasive lesions with an intact myoepithelium. Invasive carcinomas lack the myoepithelial cell layer while in the benign category, non-proliferative lesions are continuous positive, proliferative lesions show discontinuous positivity for p63.

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A Correlative Study of Fine Needle Aspiration Cytology with Histopathology of Female Breast Lesions

Fimate¹

2020

jemds

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The Role of FNAC in Diagnosis of Breast Disease at Different Ages - 208 Cases

Abstract: Introduction:Breast, a sign of womenhood and fertility has been a subject for clinicians from the time medicine is being practiced. Breast diseases are the most common ailment from which women suffer throughout the world. About 30% of women suffer from breast disease in their lifetime 1 .

Cited by 3 publications

References 5 publications

A Study of Myoepithelial Cells in Fine Needle Aspirates from Breast Lump Using Antibody to p63

A Study of Myoepithelial Cells in Fine Needle Aspirates from Breast Lump Using Antibody to p63

Role of p63 expression in non-proliferative and proliferative lesions of breast

A Correlative Study of Fine Needle Aspiration Cytology with Histopathology of Female Breast Lesions

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