The Role of Folic Acid in the Prevention of Neural Tube Defects

García-Fragoso, Lourdes; García‐García, Inés; Cadilla, Carmen L.

doi:10.5772/30971

Cited by 3 publications

(2 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Folic acid (FA), the synthetic form of folate, also known as vitamin B9, is a water-soluble B vitamin (B9). Most women do not receive the recommended daily intake of folate from diet alone [ 5 ]. Maternal use of FA supplements before and in early pregnancy can prevent a child from having a neural tube defect (NTD) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Fekadu¹,

Ketema²,

Mamo

et al. 2022

Heliyon

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…The need for FA increases dramatically during pregnancy as new cells and DNA are forming and this product cannot be significantly stored in the body [ 12 ]. The most common cause of folate deficiency is a low daily intake due to lack of ingestion of folate containing food, chronic alcoholism or total parenteral nutrition [ 5 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Fekadu¹,

Ketema²,

Mamo

et al. 2022

Heliyon

View full text Add to dashboard Cite

Evaluation of Plasma Levels of Folic Acid and Homocysteine in Babies Born With Various Types of Neural Tube Defects: A Single Center Study in South India

Singaravelu

Vasantharajan²,

Raveendra³

et al. 2022

jcbr

View full text Add to dashboard Cite

Background and objectives: Neural tube defects (NTDs) are common congenital anomalies caused by genetic, environmental, or nutritional factors. Normal plasma folic acid levels in the fetus are required for proper development of the neural tube. Plasma folic acid level has an inverse relationship with homocysteine level. This study aimed to determine plasma folic acid and homocysteine levels in babies born with NTDs and healthy controls. Methods:The study included 30 clinically diagnosed NTD cases and 30 healthy age-and sex-matched control subjects. Plasma levels of folic acid and homocysteine were measured using a direct chemiluminescence method. Data were compared using the independent t-test. Statistical analysis of data was performed using GraphPad InStat 3.0 at significance of 0.05 Results:The mean plasma level of folic acid in NTD cases (5.1±4.9 mol/l) was significantly lower than that in healthy controls (19.5±2.1 mol/l) (p<0.05). The mean plasma level of homocysteine in NTD cases (14.3 ± 2.4 ng/ml) was significantly higher than that in healthy controls (4.9±1.8 ng/ml)(p<0.05). The mean plasma level of folic acid was 20.1±1.5 µmol/l, 8.5 ±2.9 µmol/l, and 1.9 ±0.4 µmol/l in mild, moderate, and severe cases of NTD, respectively. The mean plasma level of homocysteine was 10.7±3.4 ng/ml, 15.4±1.2 ng/ml, and 18.5±0.8 ng/ml in mild, moderate, and severe cases of NTD, respectively. Conclusion: Low level of folic acid and high level of homocysteine are directly associated with the development of neural tube abnormalities. Moreover, the severity of the NTD is inversely related to plasma level of folic acid and directly related to plasma level of homocysteine.

show abstract

Developing the Right Public Health Strategies for Folic Acid and Reduction of Risk of Neural Tube Defects (NTDs) in the United Kingdom

Richardson¹

2015

EJNFS

View full text Add to dashboard Cite

The Role of Folic Acid in the Prevention of Neural Tube Defects

Cited by 3 publications

References 104 publications

Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Evaluation of Plasma Levels of Folic Acid and Homocysteine in Babies Born With Various Types of Neural Tube Defects: A Single Center Study in South India

Developing the Right Public Health Strategies for Folic Acid and Reduction of Risk of Neural Tube Defects (NTDs) in the United Kingdom

Contact Info

Product

Resources

About