The Role of Forkhead Box Proteins in Acute Myeloid Leukemia

Gurnari, Carmelo; Falconi, Giulia; Bellis, Eleonora De; Voso, Maria Teresa; Fabiani, Emiliano

doi:10.3390/cancers11060865

Cited by 23 publications

(20 citation statements)

References 121 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, members of the FoxO subfamily shuttle from the cytoplasm to the nucleus and play an important role in cell proliferation, apoptosis, differentiation and oxidative stress resistance [35,36]. As the expression level and activity of FoxO1 are significantly increased in the liver tissues of patients with severe fatty liver disease and type 2 diabetes mellitus, FoxO1 has an important role in the occurrence and progression of human metabolic syndrome [37][38][39][40]. Moreover, FoxO1 is located at the intersection of many signal transduction pathways and may become a target for the treatment or intervention of many diseases [36,41,42].…”

Section: Akt Target Proteinsmentioning

confidence: 99%

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

471

263

View full text Add to dashboard Cite

The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the components of the PI3K/AKT/mTOR signalling pathway are complicated. The regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway are important in many human diseases, including ischaemic brain injury, neurodegenerative diseases, and tumours. PI3K/AKT/mTOR signalling pathway inhibitors include single-component and dual inhibitors. Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. In this review, we briefly summarize the results of research on the PI3K/AKT/mTOR pathway and discuss the structural composition, activation, communication processes, regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway in the pathogenesis of neurodegenerative diseases and tumours.

show abstract

Section: Akt Target Proteinsmentioning

confidence: 99%

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

471

263

View full text Add to dashboard Cite

show abstract

“…In hematopoietic cells FOXO3 is also the major regulator of autophagy and mitophagy that contribute to mitigate oxidative stress by removing damaged mitochondria and toxic proteins [ 96 , 97 ]. Considered together, these findings indicate that, as a common hallmark of several hematological malignancies, impaired activity of FOXO3 leads to mitochondrial disfunctions and aberrant ROS production and thus can be associated with leukemia transformation and progression [ 98 , 99 ].…”

Section: Ros-mediated Signaling Pathways Involved In the Leukemogementioning

confidence: 99%

Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia

Trombetti

Cesaro

Catapano

et al. 2021

IJMS

View full text Add to dashboard Cite

Myeloid leukemic cells are intrinsically under oxidative stress due to impaired reactive oxygen species (ROS) homeostasis, a common signature of several hematological malignancies. The present review focuses on the molecular mechanisms of aberrant ROS production in myeloid leukemia cells as well as on the redox-dependent signaling pathways involved in the leukemogenic process. Finally, the relevance of new chemotherapy options that specifically exert their pharmacological activity by altering the cellular redox imbalance will be discussed as an effective strategy to eradicate chemoresistant cells.

show abstract

“…34 Fox proteins are a set of transcriptional factors involved in various cellular functions, such as apoptosis and proliferation. 35 Recently, Fox proteins participated in the progression of various cancers, including acute myeloid leukemia, 36 colorectal cancer 37 and osteosarcoma. 38 FOXP1 is a transcription factor with broad functions.…”

Section: Discussionmentioning

confidence: 99%

<p>Knockdown of LINC00473 Enhances Radiosensitivity in Hepatocellular Carcinoma via Regulating the miR-345-5p/FOXP1 Axis</p>

Zhang¹,

Huang²,

Chen³

et al. 2020

OTT

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Radioresistance is a significant obstacle in HCC therapy. Long non-coding RNA 473 (LINC00473) has been found to impair the effect of radiotherapy. This study aimed to explore the function and molecular basis of LINC00473 in the radiosensitivity of HCC cells. Methods: The levels of LINC00473, miR-345-5p and Forkhead Box P1 (FOXP1) were determined by quantitative real-time polymerase chain reaction. Cell viability was assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Survival fraction was calculated by colony survival assay after exposure to different doses of radiation. Cell apoptosis was evaluated by flow cytometry. The interaction among LINC00473, miR-345-5p and FOXP1 was confirmed by dual-luciferase reporter assay. The protein level of FOXP1 was detected by Western blot assay. Results: LINC00473 and FOXP1 were up-regulated, while miR-345-5p was down-regulated in HCC tissues and cells. Radiation elevated LINC00473 expression in a dose-and time-dependent manner. Depletion of LINC00473 inhibited proliferation and heightened radiosensitivity and apoptosis in HCC cells. In addition, LINC00473 was a sponge of miR-345-5p. Also, miR-345-5p overexpression sensitized HCC cells to radiation. Moreover, miR-345-5p directly targeted FOXP1. MiR-345-5p inhibition or FOXP1 up-regulation reversed the enhanced radiosensitivity caused by LINC00473 knockdown. Conclusion: LINC00473 contributed to radioresistance in HCC via modulating the miR-345-5p/FOXP1 axis, which might provide a promising diagnostic marker for HCC radiotherapy.

show abstract

The Role of Forkhead Box Proteins in Acute Myeloid Leukemia

Cited by 23 publications

References 121 publications

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia

<p>Knockdown of LINC00473 Enhances Radiosensitivity in Hepatocellular Carcinoma via Regulating the miR-345-5p/FOXP1 Axis</p>

Contact Info

Product

Resources

About