The role of free oxygen radicals on the development of otitis media with effusion

Yariktaş, Murat; Döner, Fehmi; Doğru, Harun; Yasan, Hasan; Delibaş, Namık

doi:10.1016/j.ijporl.2004.02.002

Cited by 21 publications

(18 citation statements)

References 28 publications

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“…The oxidative stress induced by oxygen free radicals has been implicated in the pathogenesis of otitis media [5,16,17]. It was reported that lipid hydroperoxide and mucosal malondialdehyde levels were increased in experimental otitis media and that oxygen free radicals in the mucosa might cause tissue damage via lipid peroxidation [6].…”

Section: Discussionmentioning

confidence: 99%

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Song¹,

Lim²,

Kim³

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Song¹,

Lim²,

Kim³

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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“…The inflammation of adenoid tissue is important rather than its volume in the formation of OME. It is known that OME does not develop in every patient with adenoid hyperplasia [3]. The antioxidant status of these patients may be a significant factor in predisposition to OME.…”

Section: Discussionmentioning

confidence: 99%

“…Hearing loss can have serious effects on a child's linguistic and educational development [2]. The precise pathogenesis of the disease remains unknown [1,3]. Multiple factors including infection, eustachian tube dysfunction, allergy, and barotrauma may responsible for the patogenesis of OME [1].…”

Section: Introductionmentioning

confidence: 99%

“…Excessive production of reactive oxygen species which is known as oxidative stress, leading to damage of nuclear and mitochondrial DNA, cell membrane lipids and intracellular proteins, resulting in cell death [5]. When the balance between reactive oxygen species production and the antioxidative defense mechanisms are disturbed, the level of reactive oxygen species increases finally lead to tissue damage [3]. Free radical damage to the membrane lipids of leukocytes results in decreased their immune function.…”

Section: Introductionmentioning

confidence: 99%

“…There are limited data on the relationship between antioxidant status and the pathogenesis of OME in humans [1,3,8]. The aim of this study is to determine whether the serum levels of vitamin A, vitamin E, copper and zinc have a role in the development of OME in childhood.…”

Section: Introductionmentioning

confidence: 99%

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Is There a Relationship Between Serum Levels of Vitamin A, Vitamin E, Copper and Zinc and Otitis Media with Effusion in Children?

Aydoğan¹,

Aydın

Taştan³

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this study is to determine whether the serum levels of vitamin A, vitamin E, copper and zinc have a role in the development of otitis media with effusion (OME) in childhood. This prospective study was conducted between February 2010 and February 2011 at a tertiary Otorhinolaryngoloy Clinic. There were 113 subjects and subdivided into three groups. Group 1 consisted of 44 patients who underwent adenoidectomy with ventilation tube placement due to OME. Group 2 consisted of 43 patients underwent adenoidectomy alone and group 3,called control group, included 26 healthy children. Serum values of vitamin A, vitamin E, copper and zinc were measured preoperatively. Comparison of the patient groups showed that group 1 patients had significantly lower serum zinc levels than group 2 patients (p = 0.002), although differences between both patients groups and controls were not significant. We found that the differences among the three groups in terms of serum levels of vitamin A, vitamin E and copper were not statistically significant (p > 0.05). The results of this study showed that serum levels of vitamin A, vitamin E and copper may not play a role on development of OME. We postulated that high serum zinc status may have the preventive effect in the predisposition to OME which may related to adenoid hyperplasia.

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Oxidative stress in chronic otitis media

Baysal

Aksoy

Kara³

et al. 2012

Eur Arch Otorhinolaryngol

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Chronic otitis media usually presents with a benign tumor-like lesion of the temporal bone known as a cholesteatoma. The role of oxidative stress in the pathogenesis of chronic otitis media and cholesteatoma has not yet been fully explored. Therefore, the aim of this study was to investigate the oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous and noncholesteatomatous chronic otitis media and in healthy subjects. A prospective controlled trial was performed on cholesteatomatous and noncholesteatomatous chronic otitis media patients in a tertiary referral center in a university hospital. A total of 75 subjects, including 25 cholesteatomatous and 25 noncholesteatomatous chronic otitis media patients and 25 healthy subjects participated in this study. Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly increased in the patient groups with or without cholesteatoma compared with the control group. Serum total antioxidant status (TAS) levels and Paraoxonase and arylesterase activity were significantly lower in the patient groups with or without cholesteatoma compared with the control group. Serum TOS and OSI levels were lower in the noncholesteatomatous group, whereas serum TAS levels were higher compared with the cholesteatomatous group. Serum arylesterase activity was significantly lower in the noncholesteatomatous group compared with the control group. The results of this study reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in cases of chronic otitis media without cholesteatoma.

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The role of free oxygen radicals on the development of otitis media with effusion

Cited by 21 publications

References 28 publications

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Is There a Relationship Between Serum Levels of Vitamin A, Vitamin E, Copper and Zinc and Otitis Media with Effusion in Children?

Oxidative stress in chronic otitis media

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