The role of G protein-coupled estrogen receptor 1 on neurological disorders

Roque, Cláudio; Mendes-Oliveira, Julieta; Duarte-Chendo, C.; Baltazar, Graça

doi:10.1016/j.yfrne.2019.100786

Cited by 31 publications

(18 citation statements)

References 149 publications

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“…GPER is also involved in regulating hippocampal synaptic plasticity. BDNF expression induced by selective GPER1 activation promotes synaptic plasticity ( 292 ). Activation of the PI3K/Akt pathway can be correlated with GPER1 activation-conferred protection in AD models ( 160 ) and PD ( 161 ).…”

Section: Ers In the Manifestation Of Diseasesmentioning

confidence: 99%

Role of estrogen receptors in health and disease

Chen

Ouyang

2022

Front. Endocrinol.

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Estrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including reproductive system-related disorders (endometriosis, and breast, ovarian, and prostate cancer), bone-related abnormalities, lung cancer, cardiovascular disease, gastrointestinal disease, urogenital tract disease, neurodegenerative disorders, and cutaneous melanoma. ER alpha (ERα), ER beta (ERβ), and novel G-protein-coupled estrogen receptor 1 (GPER1) have been identified as the most prominent ERs. This review provides an overview of ERα, ERβ, and GPER1, as well as their functions in health and disease. Furthermore, the potential clinical applications and challenges are discussed.

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Section: Ers In the Manifestation Of Diseasesmentioning

confidence: 99%

Role of estrogen receptors in health and disease

Chen

Ouyang

2022

Front. Endocrinol.

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“…Recent studies have demonstrated that GPER activation enhances protection against brain injuries (Lu et al, 2016). GPER has a high level of expression in both hippocampus and cortex (Brailoiu et al, 2007), while a GPER-selective antagonist reduces the neuroprotective effects of E2 (Gingerich et al, 2010;Roque et al, 2019). Indeed, GPER activation diminished inflammatory cytokines and blood-barrier permeability and enhanced neuronal survival in ischemic stroke animal models (Kosaka et al, 2012;Day et al, 2013;Lu et al, 2016;Zhao et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor agonists induce anti‑edema effects by altering α and β estrogen receptor gene expression

Khaksari

Hajializadeh

Esmaeili‐Mahani

et al. 2022

Acta Neurobiol. Exp.

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The present study aimed to examine whether the attenuation of estrogen receptor expression is prevented by propyl pyrazole triol (PPT), an agonist for estrogen receptor α (ERα) or and diarypropiolnitrile (DPN), an agonist for estrogen receptor β (ERβ) after traumatic brain injury (TBI). The tests performed on ovariectomized female Wistar rats included sham group, vehicle group, and treated groups: PPT, DPN, and PPT+DPN 30 minutes after TBI. Blood-brain barrier (BBB) disruption and brain water content were estimated. RT-PCR and western blotting were utilized to evaluate ESR1 and ESR2 gene and protein expression. The data indicated that PPT, DPN, and PPT+DPN attenuated TBI-induced brain edema. Also, BBB disruption after TBI was prevented in PPT, DPN, and PPT+DPN-treated TBI animals.Estrogen agonist-treated animals showed a significant elevation in Esr1 mRNA and protein expression levels in the brain tissue of TBI rats. In addition, the data indicated a significant elevation of Esr2 mRNA and protein expression levels in the brain tissue of estrogen agonist-treated TBI rats. The data shows that both ESR1 and ESR2 agonists can enhance ER mRNA and protein levels in TBI animals' brain. It appears that this effect contributes to the neuroprotective function of ER agonists.

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“…Surprisingly, we observed a gender disparity in the association between breakfast consumption and primary headaches. This disparity might be due to the different influence of sex hormones on the neurological system and primary headaches (42,43). In addition, the accuracy of dietary data might be different between males and females (44,45).…”

Section: Discussionmentioning

confidence: 99%

Breakfast consumption is inversely associated with primary headaches in university students: The MEPHASOUS study

Mansouri

Sharifi

Shokri

et al. 2019

Preprint

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Background The prevalence of primary headaches has been increasing at an alarming rate, particularly in university students. Previous studies have shown that diet-related behaviors can affect neurological disorders. Therefore, this study was conducted to examine the association between breakfast consumption patterns and primary headaches in a large population of university students.Methods In total, 83,677 university students, aged ≥18 years, from 28 provinces of Iran were included in the current cross-sectional study. Dietary intakes and breakfast consumption patterns were assessed using a validated self-administered dietary habits questionnaire. Primary headaches were determined according to the International Classification of Headache Disorders-3 (ICHD-3) criteria.Results The mean age of participants was 21.50 ± 4.01. Primary headaches were prevalent among 9% of university students. A significant inverse association was seen between breakfast consumption and odds of primary headaches (OR: 0.57, 95% CI: 0.51-0.62). This association remained significant even after taking potential confounders into account; such that students who consumed breakfast frequently had 26% lower odds of primary headaches compared with those who consumed it rarely (OR: 0.74, 95% CI: 0.65-0.85). Moreover, such a significant inverse association was observed in female students (OR: 0.54, 95% CI: 0.49-0.61) as well as those with normal weight (OR: 0.68, 95% CI: 0.58-0.79). However, it became non-significant in male students and those with overweight or obesity.Conclusions We found that frequent breakfast consumption was inversely associated with the odds of primary headaches. Further prospective studies are needed to confirm our findings.

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The role of G protein-coupled estrogen receptor 1 on neurological disorders

Cited by 31 publications

References 149 publications

Role of estrogen receptors in health and disease

Role of estrogen receptors in health and disease

Estrogen receptor agonists induce anti‑edema effects by altering α and β estrogen receptor gene expression

Breakfast consumption is inversely associated with primary headaches in university students: The MEPHASOUS study

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