The role of Ga-67 scintigraphy in evaluating the results of therapy of lymphoma patients

The Uptake Mechanism of Gallium-67 into Hepatocytes Treated with Carbon Tetrachloride

“…These results indicated that the uptake of 67 Ga was in coincidence with the hepatocytes damage by CCl 4 treatment and CCl 4 exposure for 4 h gave rise to differences between CCl 4 treatment and control. Therefore, subsequent experiments were carried out by using CCl 4 exposure for 4 h. 4 ALT activities in culture medium of PVH by CCl 4 exposure for 4 h were higher than that of PPH ( Fig. 2A).…”

“…67 Ga by PPH and PVH Following the Treatment of CCl 4 To see degree of hepatocytes damage, we determined leakage of cytosolic ALT activities (a conventional indicator of liver damage) in culture medium (Figs. 1A, B).…”

“…[22][23][24][25] Therefore, CCl 4 causes damage primarily in PVH, located in zone III surrounding the central vein. [26][27][28] Thus, there were zonal differences in CCl 4 -induced liver damage. Therefore, we thought that the uptake of 67 Ga which had been used for the detection of liver damage might have a zonal difference.…”

In vivo functional imaging with SPECT and PET

“…123 I-MIBG is also used for the diagnosis of pheochromocytoma and neuroblastoma [55]. 67 Ga has been applied in the follow-up of lymphoma treatment [56] and lung cancer [57]. Furthermore, the immunoscintigraphy of tumours is based on many different monoclonal antibodies labelled with 99m Tc, 123 I, or 111 In [58].…”

“…67 Ga has been applied in different questions, e.g. in lung cancer [57], in lymphoma after treatment [56], and in different infections [64]. SPECT has provided important diagnostic and prognostic information for orthopaedic problems related to the lower extremities [65].…”