2023
DOI: 10.3390/cancers15164179
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The Role of GAB1 in Cancer

Manuel Jesús Pérez-Baena,
Francisco Josué Cordero-Pérez,
Jesús Pérez-Losada
et al.

Abstract: GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, GAB1 transitions from the cytoplasm to the membrane where it is phosphorylated by a range of kinases. This event recruits SH2 domain-containing proteins like SHP2, PI3K’s p85 subunit, CRK, and others, thereby activating distinct signaling pathways, including MAPK, PI3K/AKT, and JNK. GAB1-deficient embryos succumb in utero, presenting with developm… Show more

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Cited by 4 publications
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