The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study

García-Cifuentes, Elkin; Márquez, Isabel; Vásquez, Daniel; Aguillón, David; Borda, Miguel Germán; Lopera, Francisco; Cano-Gutiérrez, Carlos

doi:10.1159/000510494

Cited by 14 publications

(16 citation statements)

References 61 publications

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“…Besides, regarding cognition, there is still a lack of agreement concerning MMSE-thresholds for cognitive impairment that can be generalizable to heterogeneous populations in multicenter studies, as many factors can affect MMSE scores [41]. However, the cut-offs used in both populations have also been widely used in preliminary research [24,42].…”

Section: Discussionmentioning

confidence: 99%

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

et al. 2021

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Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and South Korean older adults. Methods We performed a cross-sectional analysis of two surveys separately; The Survey on Health, Well-Being, and Aging in Colombia (SABE) (n = 23,343) and the Korean Longitudinal Study of aging (KLoSA) (n = 4556). Participants older than 50 years were selected from rural and urban areas achieving a representative sample. Here we investigated the association between BMI categories with function using zero-inflated negative binomial regressions, and with cognition using logistic regression models. Results After adjustment, in Colombia, underweight was associated with an impaired score on the Mini-mental State Examination (MMSE) and worse performance in the instrumental activities of daily living (IADL). Also, being overweight was associated with a better score on the MMSE and the IADL. For both outcomes education level significantly influenced the predictions. In South Korea, there were no significant associations for cognition, IADL, or basic activities of daily living (BADL). Conclusions In the Colombian population, underweight, was associated with reduced cognitive performance and daily functioning. Additionally, being overweight but not obese was associated with better cognition and daily functioning. In South Korea, there were no significant associations between BMI and cognition, IADL, or BADL.

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Section: Discussionmentioning

confidence: 99%

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

et al. 2021

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“…GS in the 3 meters test is not a routingly used and this results may underestimated speed (48). However, we do not consider that it biases our results as has been used in previous works (12,18). Nevertheless, the SABE Colombia study has the largest sample of Latin American older adults, providing to our analyses a good statistical power.…”

Section: Discussionmentioning

confidence: 94%

Muscular Function: An alternative way to identify cognitive impairment, Secondary Analysis From SABE-Colombia

García-Cifuentes

Botero‐Rodríguez

Velandia

et al. 2020

Preprint

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Background Traditionally, the identification of cognitive impairment is based on neuropsychological tests and supported with not widely available biomarkers. This study aimed to establish the association between motor function (Gait Speed and Handgrip Strength) and the performance in a global cognitive performance and various cognitive domains. Our secondary objective was to determine a cut-off point for Gait Speed and Handgrip Strength to classify older adults as cognitively impaired. Methods This is a secondary analysis from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015. We performed linear regression models, to establish association with motor function, clinical, and sociodemographic variables, and predict the scores of the Mini-mental State Examination and its domains (i.e. orientation, recall, counting, and language). The evaluation of the motor function variables as an instrument to separate cognitively impaired older adults was evaluated by developing a receiving operating characteristic curve (ROC). Results Gait speed was associated with orientation (r2 = 0.16), language (r2 = 0.15), recall memory (r2 = 0.14) and counting (r2 = 0.08). Similarly, handgrip strength was associated with orientation (r2 = 0.175), language (r2 = 0.164), recall memory (r2 = 0.137), and counting (r2 = 0.08). Slow gait had a cut-off point of 0,59 m/s, with an area under the curve (AUC) of 0.629 (0.613–0.646), whereas a weak handgrip strength had an AUC of 0.653 (0.645–0.661), with a cut-off point of 17.50 Kg for separating those older adults with cognitive impairment. Conclusions Gait Speed or Handgrip Strength are similarly associated with cognitive performance, exhibiting the larger associations with orientation and language domains. Gait Speed and Handgrip Strength can be easily performed by any clinician and seems to be useful screening tools to detect cognitive impairment.

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“…Our secondary objective was to determine a cut-off point for GS and HS to classify older adults as cognitively impaired. Based on our preliminary reports (11,12), we hypothesise that reduced motor function might be associated with the global cognition and some domains such as orientation and memory.…”

Section: Introductionmentioning

confidence: 99%

“…In the Colombian context, there are previous publications evidencing that motor disfunction are associated with dementia (11,12). The 5th Canadian Consensus Conference: This expert panel suggested that individuals with subjective memory complaints, motor dysfunction (i.e.…”

Section: Introductionmentioning

confidence: 99%

Muscular function: An alternative way to identify cognitive impairment—secondary analysis from SABE‐Colombia

García-Cifuentes

Botero‐Rodríguez

Velandia

et al. 2021

Alzheimer's & Dementia

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Background: Traditionally, the identification of cognitive impairment is based on neuropsychological tests and supported with not widely available biomarkers. This study aimed to establish the association between motor function (Gait Speed and Handgrip Strength) and the performance in a global cognitive performance and various cognitive domains. Our secondary objective was to determine a cut-off point for Gait Speed and Handgrip Strength to classify older adults as cognitively impaired.Method: This is a secondary analysis from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015. We performed linear regression models, to establish association with motor function, clinical, and sociodemographic variables, and predict the scores of the Mini-mental State Examination and its domains (i.e. orientation, recall, counting, and language). The evaluation of the motor function variables as an instrument to separate cognitively impaired older adults was evaluated by developing a receiving operating characteristic curve (ROC).Result: Gait speed was associated with orientation (r 2 = 0.16), language (r 2 = 0.15), recall memory (r 2 = 0.14) and counting (r 2 = 0.08). Similarly, handgrip strength was associated with orientation (r 2 = 0.175), language (r 2 = 0.164), recall memory (r 2 = 0.137), and counting (r 2 = 0.08). Slow gait had a cut-off point of 0,59 m/s, with an area under the curve (AUC) of 0.629 (0.613-0.646), whereas a weak handgrip strength had an AUC of 0.653 (0.645-0.661), with a cut-off point of 17.50 Kg for separating those older adults with cognitive impairment. Conclusion:Gait Speed or Handgrip Strength are similarly associated with cognitive performance, exhibiting the larger associations with orientation and language domains. Gait Speed and Handgrip Strength can be easily performed by any clinician and seems to be useful screening tools to detect cognitive impairment.

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The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study

Cited by 14 publications

References 61 publications

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

Muscular Function: An alternative way to identify cognitive impairment, Secondary Analysis From SABE-Colombia

Muscular function: An alternative way to identify cognitive impairment—secondary analysis from SABE‐Colombia

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