The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

Nasiri, Masoomeh; Soltani, Nepton; Mazaheri, Safoora; Maleki, Maryam; Talebi, Ardeshir; Gharibi, Fatemah; Nematbakhsh, Mehdi

doi:10.4103/2277-9175.211834

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…The findings also showed a highly significant reduction P>0.01 in the fetal body weight of group III. The current findings were agreed with those of (46)(47)(48), where all authors confirm the effect of the Platinum on the rodent's weight. Moreover, the weight reduction in the maternal bodies, liver, kidneys, and embryos in the current study may due to that Platinum alters lipid metabolism, and induce weight loss in both of the mothers, and fetuses (49).…”

Section: Discussionsupporting

confidence: 91%

Histopathological and some biochemical effects of platinum drug on the liver and kidney of pregnant mice Mus musculus and their embryos

Barwarei¹,

Sadoon²

2021

IJVS

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The current study was done to investigate the effects of two doses 3and 6 mg/kg B.w. of the Platinum drug on the structure of the liver and kidney of pregnant mice, and embryos in addition to the weight of the mothers, embryos, maternal liver and kidneys, as well as some biochemical parameters, were established. For this study, thirty pregnant mice were used, divided into three groups (10 mice/group) as follows; group I (control group); animals were injected intraperitoneally (IP) with distilled water on the days 7th, 12th, and 17th of gestation. The other both groups II, and III were injected intraperitoneally (IP) with the selected doses above of the Platinum at the days 7th, 12th, and 17th of gestation, respectively. Microscopically, maternal and fetal' liver sections of group II revealed vacuolation, swelling, apoptosis, infiltration of inflammatory cells, congestion, degeneration, and presence of the extramedullary hematopoietic cells, respectively. Previous lesions were increased in group III. Maternal and, fetal kidney sections of group II revealed degeneration, expansion of Bowman's space, inflammatory cells infiltration into interstitial tissue, and blood capillaries congestion. However, the previous lesions showed more severity in group III. The drug caused a reduction in the body weight of the mothers, selected organs, and embryos. Biochemical assessment of the maternal serum AST, ALT, and ALP levels showed an increase in both experimental groups II and III, but to varying degrees. Moreover, both groups II and III showed an increase in the levels of the maternal BUN and, urea. Whist, group III showed a significant increase of the creatinine compared to the control group. In conclusion, using anticancer drugs during pregnancy will harm both mothers and fetal organs. The risk of these medications represents their ability to cross the placenta and enters the fetal body. Therefore, the drug may affect the formation of the fetal organs. The drug also alters the regulatory antioxidant mechanism in the maternal body during the treatment duration. The drug should be used under medical follow up.

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Section: Discussionsupporting

confidence: 91%

Histopathological and some biochemical effects of platinum drug on the liver and kidney of pregnant mice Mus musculus and their embryos

Barwarei¹,

Sadoon²

2021

IJVS

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Pharmacogenomics: The roles of genetic factors on treatment response and outcomes in diabetes

Wang,

Chow,

Tomlinson

2024

Internet of Things and Machine Learning for Type I and Type II Diabetes

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Sex Difference in Cisplatin-Induced Nephrotoxicity: Laboratory and Clinical Findings

Eshraghi-Jazi

Nematbakhsh

2022

Journal of Toxicology

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Cisplatin (CP) as the most important anticancer drug has limited usage due to a lot of side effects such as nephrotoxicity. Additionally, nephrotoxicity is gender/sex-related. There is a variety of experimental studies in association with sex and CP-induced nephrotoxicity. Some studies have reported that female sex is resistant than male sex due to greater antioxidant defense and protective effects of estrogen in females. Other studies have indicated that males are less vulnerable than females due to CP high clearance. Also, various supplementations have revealed conflicting effects in males and females. It is uncovered that sex hormones have determinant roles on the conflicting effects. Some supplements could improve CP-induced nephrotoxicity, but several supplements intensified CP-induced nephrotoxicity, especially in female sex. On the other hand, major clinical studies introduced female gender as a risk factor of CP-induced nephrotoxicity. Although, rare studies evaluated the effect of various supplemental compounds on CP-induced nephrotoxicity in patients underwent CP therapy. Therefore, it requires further investigations to clarify the controversial subject of gender/sex and CP-induced nephrotoxicity in both clinic and laboratory.

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The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

Cited by 4 publications

References 47 publications

Histopathological and some biochemical effects of platinum drug on the liver and kidney of pregnant mice Mus musculus and their embryos

Histopathological and some biochemical effects of platinum drug on the liver and kidney of pregnant mice Mus musculus and their embryos

Pharmacogenomics: The roles of genetic factors on treatment response and outcomes in diabetes

Sex Difference in Cisplatin-Induced Nephrotoxicity: Laboratory and Clinical Findings

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