The role of Gelam honey in accelerating reepithelialization of ex vivo corneal abrasion model

Azmi, Muhammad Fairuz; Ghafar, Norzana Abd; Hamzah, Jemaima Che; Chua, Kien Hui; Ng, Sook-Luan

doi:10.1111/jfbc.13645

Cited by 6 publications

(4 citation statements)

References 38 publications

(53 reference statements)

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“…Furthermore, all the nutritious components present in honey (sugars, amino acids, vitamins, and other trace elements) stimulate cell growth and the development of repair tissues [70][71][72]79,80]. In addition, re-epithelialization would also be promoted by the incre-ment of TNF-α and interleukin-1β (IL-1β) levels.…”

Section: Healing-rate Promotermentioning

confidence: 99%

Role of Honey in Advanced Wound Care

et al. 2021

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Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fibrous membranes and hydrogels) is also presented and discussed.

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Section: Healing-rate Promotermentioning

confidence: 99%

Role of Honey in Advanced Wound Care

et al. 2021

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“…RJ has been used in conventional ophthalmic remedies like honey eye drops for corneal wound healing ( Azmi et al, 2021 ) and propolis for protecting retinal neurons ( Abd Rashid et al, 2022 ). Studies have demonstrated that RJ enhances tear secretion by promoting Ca 2+ mobilization and conserving ATP in lacrimal glands through muscarinic signaling pathways ( Inoue et al, 2017 ).…”

Section: Impact Of Nutrients On the Ocular Surface And Potential Risksmentioning

confidence: 99%

Recommendations for nutritional supplements for dry eye disease: current advances

Cong,

Zhang,

Han

et al. 2024

Front. Pharmacol.

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Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact of oral nutritional supplements, varying in composition and dosage, on the symptoms of DED. The main components of these supplements include fish oils (Omega-3 fatty acids), vitamins, trace elements, and phytochemical extracts. Beyond these well-known nutrients, it is necessary to explore whether novel nutrients might contribute to more effective DED management. This review provides a comprehensive update on the therapeutic potential of nutrients and presents new perspectives for combination supplements in DED treatment.

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“…Apart from its high sugar content, GH contains a substantial amount of vitamins C, B1, and B3; flavonoids; and many other components [159]. In comparison to AH, as low as 0.0015% of GH concentration has been reported to enhance the proliferation of corneal keratocytes and CECs while retaining their phenotypical expression [160,161].…”

Section: Corneal Injurymentioning

confidence: 99%

Therapeutic Potential of Honey and Propolis on Ocular Disease

et al. 2022

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Honey and propolis have recently become the key target of attention for treating certain diseases and promoting overall health and well-being. A high content of flavonoids and phenolic acids found in both honey and propolis contributes to the antioxidant properties to scavenge free radicals. Honey and propolis also exhibited antibacterial effects where they act in two ways, namely the production of hydrogen peroxide (H2O2) and gluconic acids following the enzymatic activities of glucose oxidase, which exerts oxidative damage on the bacteria. Additionally, the anti-inflammatory effects of honey and propolis are mainly by reducing proinflammatory factors such as interleukins and tumor necrosis factor alpha (TNF-α). Their effects on pain were discovered through modulation at a peripheral nociceptive neuron or binding to an opioid receptor in the higher center. The aforementioned properties of honey have been reported to possess potential therapeutic topical application on the exterior parts of the eyes, particularly in treating conjunctivitis, keratitis, blepharitis, and corneal injury. In contrast, most of the medicinal values of propolis are beneficial in the internal ocular area, such as the retina, optic nerve, and uvea. This review aims to update the current discoveries of honey and propolis in treating various ocular diseases, including their antioxidant, anti-inflammatory, antibacterial, and anti-nociceptive properties. In conclusion, research has shown that propolis and honey have considerable therapeutic promise for treating various eye illnesses, although the present study designs are primarily animal and in vitro studies. Therefore, there is an urgent need to translate this finding into a clinical setting.

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The role of Gelam honey in accelerating reepithelialization of ex vivo corneal abrasion model

Cited by 6 publications

References 38 publications

Role of Honey in Advanced Wound Care

Role of Honey in Advanced Wound Care

Recommendations for nutritional supplements for dry eye disease: current advances

Therapeutic Potential of Honey and Propolis on Ocular Disease

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