The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones

Gareeva, A E; Бадретдинов, У.Г.; Akhmetova, E. A.; Kinyasheva, K.O.; Nasibullin, T. R.; Самигуллина, Л. И.; Тимербулатов, И Ф; Тимербулатова, М Ф; Asadullin, Azat R.

doi:10.17116/jnevro202012010169

Cited by 4 publications

(6 citation statements)

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“…The role of dopamine receptor genes in suicidal behavior has also been described by other authors [10]. There is evidence of the importance of dopamine in the formation of alcohol dependence.…”

Section: Discussionsupporting

confidence: 55%

“…Suicidal behavior is often formed in the structure of mental disorders and disorders caused by alcohol consumption [5]. Among people dependent on psychoactive substances, the risk of developing suicidal thoughts and attempts is especially high [6]. So, H.M. Inskip et al showed that the lifetime risk of suicide in people with alcohol dependence was higher than in people with mood disorders [7].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Associations of the Polymorphic Variant of the DRD2 (rs1800497) Gene with Forms of Suicidal Behavior in Patients with Alcohol Dependence

Bardina,

Efremova,

Baikova3

et al. 2024

jour

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Suicide is a serious public health problem. A deeper understanding of the underlying mechanisms and processes that lead to suicidal behavior is crucial for the development of effective preventive strategies. The study and identification of biomarkers will help in understanding the underlying processes or changes associated with suicide, however, studies linking biomarkers to suicide are limited and fragmented. Objective- To study the genetic associations of the polymorphic variant of the DRD2 gene (rs1800497) with forms of suicidal behavior in patients with alcohol dependence. Materials and methods: The association of polymorphic variants of the gene DRD2 (rs1800497) was analysed in patients with alcohol dependence syndrome, with a history of suicidal behavior and without it, living in the Republic of Bashkortostan, who were treated at the Republican Narco-logical Dispensary in the period from 2019 to 2021. Results: the presence of suicidal tendencies was detected in 39% of patients (136/344). 30% (42/136) were classified as patients with ex-ternal and internal forms of suicidal behavior, 70% (94/136) had only internal forms of suicidal behavior. Carriages of the CC and TT genotypes of the DRD2 gene (rs1800497) are characterized by a lower frequency of occurrence of all forms of suicidal behavior than carriages of СТ genotype. Also, carriages of the CC genotype of the DRD2 gene (rs1800497) are characterized by a lower frequency of occurrence of external forms of suicidal behavior than carriages of СТ and TT genotypes. Conclusions. The data we present indicate the possible contribution of genetic factors to the risk of suicidal behavior in individuals with alcohol dependence syndrome. There is a need for further research to explain the relationships between the circadian rhythm system, alcohol use disorders and suicidal behavior.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Genetic Associations of the Polymorphic Variant of the DRD2 (rs1800497) Gene with Forms of Suicidal Behavior in Patients with Alcohol Dependence

Bardina,

Efremova,

Baikova3

et al. 2024

jour

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“…For the rs6313 polymorphism, the data in the literature demonstrate an association with the cognitive function level [80] and Alzheimer's disease [81] and show a nominal association with panic disorder [82]. The connection of psychiatric disorders with the rs6313 polymorphism in 5HT2A has also been investigated in the Russian population [83,84]. In particular, polymorphism has been shown to contribute to the development of suicidal behavior in individuals with addictions and schizophrenia patients [44,83].…”

Section: Europeanmentioning

confidence: 99%

BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia

Morozova,

Ushakova,

Pavlova

et al. 2024

Genes

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The prevalence of mental disorders and how they are diagnosed represent some of the major problems in psychiatry. Modern genetic tools offer the potential to reduce the complications concerning diagnosis. However, the vast genetic diversity in the world population requires a closer investigation of any selected populations. In the current research, four polymorphisms, namely rs6265 in BDNF, rs10835210 in BDNF, rs6313 in HTR2A, and rs1800955 in DRD4, were analyzed in a case–control study of 2393 individuals (1639 patients with mental disorders (F20-F29, F30-F48) and 754 controls) from the European part of Russia using the TaqMan SNP genotyping method. Significant associations between rs6265 BDNF and rs1800955 DRD4 and mental impairments were detected when comparing the general group of patients with mental disorders (without separation into diagnoses) to the control group. Associations of rs6265 in BDNF, rs1800955 in DRD4, and rs6313 in HTR2A with schizophrenia in patients from the schizophrenia group separately compared to the control group were also found. The obtained results can extend the concept of a genetic basis for mental disorders in the Russian population and provide a basis for the future improvement in psychiatric diagnostics.

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“…In modern psychiatry, the problem of suicidal behavior is still one of the most relevant. [1,2,3]. According to the World Health Organization, 25-50% of suicide victims suffered from disorders associated with the use of alcohol and other psychoactive substances, while of all deaths from suicide 22% can be attributed to alcohol use [4].…”

Section: Introductionmentioning

confidence: 99%

Association of single nucleotide variants rs34532313 of the <i>MTNR1A</i> gene and rs10830963 of the <i>MTNR1B</i> gene with suicidal risk in alcohol dependence syndrome and insomnia

Efremov

Asadullin

Akhmetova

et al. 2022

jour

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Background: Suicidal behaviour is the leading cause of mortality from external causes at all ages worldwide. More than a million people commit completed suicide each year. According to the World Health Organisation, 25-50% of suicide victims suffered from alcohol and other substance use disorders, 22% of all suicide deaths were attributable to alcohol use (WHO, 2014). Several papers have suggested potential associations of insomnia and increased suicide risk in patients with alcoholism. We hypothesise that mutations in melatonin receptor genes may be associated with suicide risk in patients with alcoholism.Methods. The Insomnia Severity Index (ISI) was used as a tool to assess the presence and severity of insomnia. The Columbia Suicide Severity Rating Scale (C-SSRS) was used as a method to examine suicidal behavior. Genotyping of MTNR1A (rs34532313), MTNR1B (rs10830963) genes was performed using real-time polymerase chain reaction (RT-PCR). A comparative genetic study of two groups of patients was carried out: the first group, patients with alcohol dependence syndrome (F10.2); the second group, patients with alcohol dependence syndrome (F10.2) and insomnia, which persisted 7-14 days after starting alcohol withdrawal therapy.Results. Suicidal thoughts and a history of auto-aggressive behaviour were more common in subjects with insomnia in the post-withdrawal period. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were more likely to have suicidal thoughts and a history of suicide attempts in a genetic study of patients with insomnia.Conclusions. Our study found that the TT genotype of the MTNR1A gene (rs34532313) is a genetic marker of suicidal behaviour risk in patients with insomnia in the post-withdrawal period. However, the same pattern was not observed in patients without insomnia.

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The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones

Cited by 4 publications

References 50 publications

Genetic Associations of the Polymorphic Variant of the DRD2 (rs1800497) Gene with Forms of Suicidal Behavior in Patients with Alcohol Dependence

Genetic Associations of the Polymorphic Variant of the DRD2 (rs1800497) Gene with Forms of Suicidal Behavior in Patients with Alcohol Dependence

BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia

Association of single nucleotide variants rs34532313 of the <i>MTNR1A</i> gene and rs10830963 of the <i>MTNR1B</i> gene with suicidal risk in alcohol dependence syndrome and insomnia

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