The role of genetics in cognitive remediation in schizophrenia: A systematic review

Penadés, Rafael; Bosia, Marta; Catalán, Rosa; Spangaro, Marco; García-Rizo, Clemente; Amoretti, Sílvia; Bioque, Miquel; Bernardo, Miquel

doi:10.1016/j.scog.2019.100146

Cited by 5 publications

(2 citation statements)

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“…Genetic factors influencing CR response have also been investigated. A recent review on the topic identified polymorphisms in the Catechol-O-Methyltransferase (COMT), Brain-Derived Neurotrophic Factor (BDNF) and Excitatory Amino Acid Transporter-2 (EAAT2) genes as candidate predictors of CR outcomes ( Penadés et al, 2020a ). In details, the BDNF Met allele seems to inhibit the positive changes in BDNF serum levels after CR, thus hampering CR effects, similarly the COMT Val allele, associated to reduced prefrontal dopamine levels, appears to limit the cognitive improvements.…”

Section: Treatment Of Cognitionmentioning

confidence: 99%

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Harvey

Bosia

Cavallaro

et al. 2022

Schizophrenia Research: Cognition

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Section: Treatment Of Cognitionmentioning

confidence: 99%

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Harvey

Bosia

Cavallaro

et al. 2022

Schizophrenia Research: Cognition

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“…Neuroimaging studies suggest that cortical reserve, defined as grey matter volume ( 28 ), cortical thickness ( 29 ), and integrity of the right fronto-occipital fasciculus, right corticospinal tract and bilateral medial lemnisci ( 30 ) can moderate the response to CRT in cognitive domains such as social cognition, verbal and non-verbal memory, attention/vigilance, and executive function. However, two recent reviews have concluded that specific biological pathways underlying cognitive remediation are still unclear, and the authors could not provide any guidance on clinical decision-making in this field ( 21 , 31 ).…”

Section: Introductionmentioning

confidence: 99%

Free Thyroxine Concentrations Moderate the Response to a Cognitive Remediation Therapy in People With Early Psychosis: A Pilot Randomized Clinical Trial

et al. 2020

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Introduction Cognitive deficits are a cause of functional disability in psychotic disorders. Cognitive remediation therapy (CRT) might be applied to improve these deficits. We conducted a pilot study to explore whether thyroid hormones might predict the response to CRT in patients with recent-onset psychosis (ROP). Methods Twenty-eight stable ROP outpatients (9 women) were randomized to receive computerized CRT (N=14) or treatment as usual (TAU) (N=14), over three months. Both cognitive and thyroid functions were assessed at the baseline and after those three months to all patients. A full cognitive battery (CANTAB) was administered before and after the treatment. Serum levels of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured. FT4 concentrations were recoded into a dichotomic variable (FT4 group) based on the median of the sample (1.2 ng/dL). Data were analyzed on an intention-to-treat basis with linear mixed models. Afterwards, we offered CRT to all participants from the TAU group and seven enrolled CRT, reassessing them when finished. Secondary analyses were repeated in a sample of 14 participants who completed the CRT (either from the beginning or after the TAU period) and attended at least one third of the sessions. Results The linear mixed models showed a significant time x CRT x FT4 group effect in two cognitive tasks dealing with executive functions and sustained attention (participants with higher FT4 concentrations worsened executive functions but improved sustained attention after CRT). In the secondary analysis including all patients assigned to CRT, higher FT4 concentrations were associated with a poorer response in verbal memory but a better response in spatial working memory. Conclusions Free thyroxine concentrations moderate the response to a CRT in patients with early psychosis.

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Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation

Marable

Frank

Seim

et al. 2021

Toxicological Sciences

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Development of in vitro new approach methodologies (NAMs) has been driven by the need for developmental neurotoxicity (DNT) hazard data on thousands of chemicals. The network formation assay (NFA) characterizes DNT hazard based on changes in network formation but provides no mechanistic information. This study investigated nervous system signaling pathways and upstream physiological regulators underlying chemically-induced neural network dysfunction. Rat primary cortical neural networks grown on microelectrode arrays were exposed for 12 days in vitro (DIV) to cytosine arabinoside (CA), 5 fluorouracil (5FU), domoic acid (DA), cypermethrin (CM), deltamethrin (DM), or haloperidol (HP) as these exposures altered network formation in previous studies. RNA-seq from cells and GC/MS analysis of media extracts collected on DIV 12 provided gene expression and metabolomic identification, respectively. The integration of differentially expressed genes and metabolites for each neurotoxicant was analyzed using Ingenuity Pathway Analysis (IPA). All six compounds altered gene expression that linked to developmental disorders and neurological diseases. Other enriched canonical pathways overlapped among compounds of the same class; for example, genes and metabolites altered by both CA and 5FU exposures are enriched in axonal guidance pathways. Integrated analysis of upstream regulators was heterogeneous across compounds, but identified several transcriptomic regulators including CREB1, SOX2, NOTCH1, and PRODH. These results demonstrate that changes in network formation are accompanied by transcriptomic and metabolomic changes and that different classes of compounds produce differing responses. This approach can enhance information obtained from NAMs and contribute to the identification and development of adverse outcome pathways (AOPs) associated with DNT.

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The role of genetics in cognitive remediation in schizophrenia: A systematic review

Cited by 5 publications

References 50 publications

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Free Thyroxine Concentrations Moderate the Response to a Cognitive Remediation Therapy in People With Early Psychosis: A Pilot Randomized Clinical Trial

Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation

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