The Role of Genotype in Behavioral Responses to Anesthetics

Elias, Merrill F.; Pentz, Clyde A.

doi:10.1007/978-1-4615-7697-6_11

Cited by 3 publications

(2 citation statements)

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“…Exactly the same procedures as those reported in Experiment I were used for Experiment 2. Mean systolic BP(mm Hg) was 85 2 3.8. this was consistent with findings reported by Elias and Pentz (1975) for C57BL/6J mice.…”

Section: Methodssupporting

confidence: 95%

“…The high line BP values are in a range which may be considered excessive relative to the inbred mouse strains most commonly used in research; the low line mice fell within what might be considered the normal range (Elias & Pentz, 1975;Schlager, 1966; Schlager & Weibust, 1967). Correlations between direct diastolic BP and indirect systolic BP were I' = 0.97 for low line (N = 7) and r = 0.94 (N = 1 I ) for high line mice measured in the Kansas laboratory.…”

Section: Methodsmentioning

confidence: 97%

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“Spontaneously” hypertensive mice: A potential genetic model for the study of the relationship between heart size and blood pressure

Elias

Sorrentino

Pentz

et al. 1975

Experimental Aging Research

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Mice selected genetically for high and low blood pressure (BP) were compared with regard to heart weight and heart/body ratios. Two experiments were performed with mice ranging in age from 1.3 to 9 months and 11 to 23 months respectively. In a third experiment C57BL/6J mice were compared to the high and low BP mice. Heart/body ratios and heart weights, adjusted fo body weight via covariance analysis, were significantly greater for the high BP mice, but no Age x BP Genotype interaction was observed. Results were discussed in terms of a possible relationship between heart weight and BP via genetic linkage or pleiotropy. The possibility was also raised that compensatory mechanisms for high blood pressure, e.g., cardiac hypertrophy, may operate very early in development for animals who are hypertensive by virtue of selective breeding for blood pressure extremes.

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Section: Methodssupporting

confidence: 95%

Section: Methodsmentioning

confidence: 97%