The Role of Geometric Parameters in the Prediction of Abdominal Aortic Aneurysm Wall Stress

Georgakarakos, Efstratios; Ioannou, Christos V.; Kamarianakis, Yiannis; Papaharilaou, Yannis; Kostas, Theodoros; Manousaki, Eirini; Katsamouris, Asterios

doi:10.1016/j.ejvs.2009.09.026

Cited by 99 publications

(87 citation statements)

References 30 publications

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“…The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms. In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10].…”

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confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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“…Both studies were based on computational models without taking into account the presence of thrombus. Others have reported a correlation between PWS and centerline tortuosity in AAA models with ILT (Georgakarakos et al, 2010). While the major difference in the abovementioned studies is whether or not ILT was integrated into the model, they all agree that geometric features will play a significant role in prospective studies estimating the risk of AAA expansion or rupture.…”

Section: Evaluating the Aaa Geometrymentioning

confidence: 93%

Pathopysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem

Georgakarakos¹,

Ioannou²

2011

Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

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“…Even though the material of AAA exhibits heterogeneity and anisotropy in-vivo, homogeneous and isotropic material properties were assigned to govern the mechanical response of the AAA wall. The solid model of AAA was simplified and idealized for this comparative study; the stress distribution and the resulted peak wall stress would exhibit wide variations on patient-specific models [26]. Constant blood pressure was applied to the inner wall of AAA and a fluid-structure interaction detail will provide more accurate stress estimation [27,28].…”

Section: Resultsmentioning

confidence: 99%

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

Zhao¹,

Li²,

Gu³

2012

JBiSE

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Objectives: The purpose of this research is to determine the quantitative relationship between the peak wall stress of abdominal aortic aneurysm (AAA) and its clinical risk factors including its maximum diameter, asymmetry index, wall thickness and abnormal high blood pressure. Methods: The response surface experimental design with one response and four variables was used to design the experimental tests. Thirty experiments were performed through finite element analysis in order to obtain the designed response values. Results: A nonlinear multivariable regression function was developed based on the experimental data. Results demonstrated the inefficiency of traditional 5-cm criterion for estimating the rupture of AAA. The profound effect of wall thickness on the peak wall stress has been observed and validated by the existing publications. Conclusion: The conventional 5-cm criterion for estimating AAA rupture might induce biased prediction, and multiple clinical risk factors need to be considered in realistic clinical settings.

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The Role of Geometric Parameters in the Prediction of Abdominal Aortic Aneurysm Wall Stress

Cited by 99 publications

References 30 publications

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Pathopysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

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