2012
DOI: 10.1111/j.1444-0938.2012.00741.x
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The role of glia in retinal vascular disease

Abstract: Retinal vascular diseases collectively represent a leading cause of blindness. Unsurprisingly, pathological characterisation and treatment of retinal 'vascular' diseases have primarily focused on the aetiology and consequences of vascular dysfunction. Far less research has addressed the contribution of neuronal and glial dysfunction to the disease process of retinal vascular disorders. Ample evidence now suggests that retinal vasculopathy only uncommonly occurs in isolation, usually existing in concert with ne… Show more

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Cited by 108 publications
(109 citation statements)
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References 215 publications
(307 reference statements)
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“…IL-10 is an anti-inflammation cytokine, and our results further showed IL-10 was decreased in BV2 cells induced by apelin. It was well known that the inflammatory cytokines secreted by over-activated microglia participated in the progression of DR and caused the damage of retina [40,41]. According to our results, we presumed apelin enhanced the expression of inflammatory cytokines secreted by microglia, which was involved in pathological damage of DR.…”
Section: Discussionmentioning
confidence: 50%
“…IL-10 is an anti-inflammation cytokine, and our results further showed IL-10 was decreased in BV2 cells induced by apelin. It was well known that the inflammatory cytokines secreted by over-activated microglia participated in the progression of DR and caused the damage of retina [40,41]. According to our results, we presumed apelin enhanced the expression of inflammatory cytokines secreted by microglia, which was involved in pathological damage of DR.…”
Section: Discussionmentioning
confidence: 50%
“…Our study also highlights the role of the neuroretina and particularly the sEH in Müller cells in the regulation of retinal angiogenesis. It will be interesting to determine whether or not this mechanism can be exploited and whether the pathological retinal angiogenesis associated with Müller cell activation (Coorey et al, 2012), such as that observed in oxygen-induced retinopathy in preterm infants, can be linked to altered lipid signaling and modulated by sEH inhibition.…”
Section: Discussionmentioning
confidence: 99%
“…34 Collectively, these changes lead to upregulation of angiogenic molecules VEGF-A, erythropoietin (EPO), and other vascular growth factors [34][35][36][37] and result in pathologic angiogenesis, increased vascular leakage, and bleeding. [38][39][40] Diabetes-induced dysfunctional cerebral neovascularization response is vastly different from the neovascularization observed in other vascular beds. In the coronary circulation, diabetes alters the balance between pro-and antiangiogenic growth factors, impairs endothelial function, and mediates an imbalance in microenvironment redox state of the coronary circulation 41 resulting in impaired coronary collateral growth and cardiac angiogenesis.…”
Section: Diabetes and Neovascularizationmentioning
confidence: 99%