National science systems have become embedded in global science, and countries do everything they can to harness global knowledge to national economic needs. However, accessing and using the riches of global knowledge can occur only through scientists. Consequently, the research power of nations relies on the research power of individual scientists. Their capacity to collaborate internationally and to tap into the global networked science is key. The constantly evolving, bottom-up, autonomous, self-regulating, and self-focused nature of global science requires deeper understanding; and the best way to understand its dynamics is to understand what drives academic scientists in their work. In empirical terms, this chapter describes the globalization of science using selected publication, collaboration, and citation data from 2000 to 2020.