The role of glucocorticoid receptor gene in the association between attention deficit-hyperactivity disorder and smaller brain structures

Bandeira, Cibele Edom; Grevet, Eugênio H.; Cupertino, Renata B.; Tavares, Maria Eduarda de Araujo; Gusmão, Clara S; Kappel, Djenifer B.; Vitola, Eduardo S.; Picon, Felipe Almeida; Rohde, Luís Augusto; Silva, Bruna Santos da; Bau, Claiton Henrique Dotto; Rovaris, Diego Luiz

doi:10.1007/s00702-021-02425-w

Cited by 3 publications

(1 citation statement)

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“…Although methodological issues challenge the identification of brain aspects related to ADHD, such associations are supported by genomic studies showing a high genetic correlation between ADHD and several neuroimaging measures, including intracranial and total brain volumes and cortical surface area [133][134][135][136]. Additionally, it was suggested the neuroimaging associations observed in children may also be detected in adults depending on the genotype profile [137]. Therefore, the genetic architecture of ADHD may be shared to some extent with brain structure variation in both children and adults.…”

Section: Brain Structural and Functional Alterations In Adhdmentioning

confidence: 99%

An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder

et al. 2023

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Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition characterized by developmentally inappropriate symptoms of inattention and/or hyperactivity/impulsivity, which leads to impairments in the social, academic, and professional contexts. ADHD diagnosis relies solely on clinical assessment based on symptom evaluation and is sometimes challenging due to the substantial heterogeneity of the disorder in terms of clinical and pathophysiological aspects. Despite the difficulties imposed by the high complexity of ADHD etiology, the growing body of research and technological advances provide good perspectives for understanding the neurobiology of the disorder. Such knowledge is essential to refining diagnosis and identifying new therapeutic options to optimize treatment outcomes and associated impairments, leading to improvements in all domains of patient care. This review is intended to be an updated outline that addresses the etiological and neurobiological aspects of ADHD and its treatment, considering the impact of the “omics” era on disentangling the multifactorial architecture of ADHD.

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