The role of glucocorticoids in the regulation of thyrotropin

Brabant, A.; Brabant, Georg; Schuermeyer, Th.; Ranft, Ulrich; Schmidt, Frauke; Hesch, R. D.; Mühlen, A. von zur

doi:10.1530/acta.0.1210095

Cited by 71 publications

(44 citation statements)

References 16 publications

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“…34,35 Glucocorticoids are known to inhibit TSH secretion in a dose-dependent manner. 36,37 Surprisingly, in our patients TSH did not differ between the two groups either receiving corticosteroids or not. In Wehmann's study 31 TSH was also not influenced by the use of steroids.…”

Section: Discussioncontrasting

confidence: 58%

Low T3-syndrome and nutritional status as prognostic factors in patients undergoing bone marrow transplantation

Schulte

Reinhardt

Beelen³

et al. 1998

Bone Marrow Transplant

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Summary:Bone marrow transplantation is known to be associated with considerable morbidity and mortality. The aim of this study was to determine the influence of nutritional status and development of sick euthyroid syndrome as prognostic factors for outcome after BMT. In 100 patients who underwent transplantation the following parameters were assessed before and at day 14 and 28 after transplantation: anthropometric data (body weight, body mass index, body composition, grip strength), rapid turnover proteins transferrin and prealbumin, T4, T3, free T4, reverse T3, thyroid-stimulating hormone and thyroglobulin. Following bone marrow transplantation, 22 patients died in the short-term follow-up (group A) before day 140 after BMT, 21 patients died during further follow-up between days 140 and 365 (group B) and 57 patients survived longer than 365 days (group C). All patients experienced a significant decrease of transferrin and T3, accompanied by an increase of rT3 and rT3/T3 ratio at day 14 after BMT. At day 28 after BMT, patients in group C showed recovery from these changes with an increase of transferrin and a fall in rT3 and the rT3/T3-ratio, which was not seen in patients who died during further follow-up (groups A and B). The observed changes were independent of other prognostically relevant factors (type of disease, HLA-match, immunosuppression). Impaired nutritional status and development of a sick euthyroid syndrome, without tendency to recovery, are associated with a higher probability of fatal outcome after bone marrow transplantation and have prognostic relevance in this group of patients.

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Section: Discussioncontrasting

confidence: 58%

Low T3-syndrome and nutritional status as prognostic factors in patients undergoing bone marrow transplantation

Schulte

Reinhardt

Beelen³

et al. 1998

Bone Marrow Transplant

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“…However, only few publications on these data exist, and they often take only the variation of a single variable into account (Cavedon et al 2005, Meyburg et al 2001, Chace et al 2003, Honzík et al 2005, Corte and Venta 2010, Duran 2008, Matern 2008. The influence of some medications, such as dopamine and steroids upon thyroid-stimulating hormone (TSH) (Wilber and Utiger 1969, Brabant et al 1989, Haugen 2009) and 17α-hydroxyprogesterone (17-OHP), respectively, is well known (Rohrer et al 2003). For children who need a blood transfusion, all screening programs recommend that a first sample should be taken before transfusion and a second sample 3-14 days after the last transfusion.…”

Section: Introductionmentioning

confidence: 99%

Postprandial changes of amino acid and acylcarnitine concentrations in dried blood samples

Fingerhut

Arevalo

Baumgartner

et al. 2010

J of Inher Metab Disea

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Blood sampling for newborn screening cannot be standardized as for example blood collection in adults after an overnight fast. Therefore the influence of postprandial changes and individual variation is valuable information for the assessment of sensitivity and specificity of newborn screening for certain disorders. We have analyzed 92 pairs of dried blood samples taken pre- and one hour postprandially, respectively. We have determined the mean increase in metabolite concentration and calculated its significance. Individual variation after an overnight fast in healthy adults (n = 3) was between 12 and 32% (SD). Postprandial increases of acylcarnitines were mostly not significant and not exceeding 10%. Postprandial increase of amino acids was highly significant for most proteinogenic amino acids, but not for all. With the collected data we were able to estimate that mainly decreased levels of methionine and, to a lesser extent, of free carnitine could be "masked" by postprandial increases of the respective metabolites, and could therefore lead to false negative results for the detection of disorders of cobalamin metabolism and carnitine transporter deficiency.

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“…The effects of glucocorticoids on cells producing pituitary hormones such as growth hormone (GH; Martinoli and Pelletier 1989;Martinoli et al 1991;Miell et al 1991;Nogami and Tachibana 1993;Thakore and Dinan 1994), ACTH (Canny 1990;Plotsky 1991;Stephanou et al 1992;Luo et al 1995), and thyroid-stimulating hormone (TSH; Brabant et al 1989;Taylor et al 1995) have been studied already. Immunoreactivity for GR in the pituitary gland has been shown by some groups (Antakly and Eisen 1984;Antakly et al 1987;Yokote et al 1991;Kononen et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Cellular localization and distribution of glucocorticoid receptor immunoreactivity and the expression of glucocorticoid receptor messenger RNA in rat pituitary gland

Ozawa

Itō

Ochiai

et al. 1999

Cell and Tissue Research

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By means of double immunohistochemical techniques and a nonradioisotopic in situ hybridization method, we determined the colocalization pattern of glucocorticoid receptor (GR) and pituitary hormones and the GR messenger RNA (mRNA) expression in the pituitaries of Wistar adult male rats. Immunoreactivity for GR was detected in the nuclei of cells in the anterior and posterior pituitary. Double immunohistochemistry revealed that the colocalization of GR and anterior pituitary hormones occurred in almost 99% of the growth hormone (GH)-producing cells and adrenocorticotropic hormone (ACTH)-producing cells, and in 67% of the thyroid stimulating hormone (TSH)-producing cells. Almost all of the folliculostellate cells (93%), marginal layer cells (94%) in the anterior pituitary, and pituicytes (96%) in the posterior pituitary immunostained for S100 protein antibody were also immunostained with GR. GR mRNA was abundant in the cytoplasm of anterior and intermediate pituitary cells but scattered sparsely in that of the posterior pituitary. These results suggest that glucocorticoids directly influence certain pituitary cells in order to regulate cell function, including the synthesis and/or secretion of hormones.

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The role of glucocorticoids in the regulation of thyrotropin

Cited by 71 publications

References 16 publications

Low T3-syndrome and nutritional status as prognostic factors in patients undergoing bone marrow transplantation

Low T3-syndrome and nutritional status as prognostic factors in patients undergoing bone marrow transplantation

Postprandial changes of amino acid and acylcarnitine concentrations in dried blood samples

Cellular localization and distribution of glucocorticoid receptor immunoreactivity and the expression of glucocorticoid receptor messenger RNA in rat pituitary gland

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