The Role of Glucocorticoids in the Management of COVID-19

Alexaki, Vasileia Ismini; Henneicke, Holger

doi:10.1055/a-1300-2550

Cited by 41 publications

(42 citation statements)

References 92 publications

(133 reference statements)

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“…Datorită acestor efecte antiinflamatoare, GC reprezintă un pilon al terapiilor imunosupresive. Glucocorticoizii sintetici (dexametazona, metilprednisolon, prednisolon) prezintă o potență mai mare în comparație cu cortizolul, datorită timpului de înjumătățire mai lung în plasmă, absorbției mai bune și reducerii legării cu globulinele specifice [7].…”

Section: Materiale șI Metodeunclassified

“…Meta-analiza, efectuată de grupul de lucru al OMS, a concluzionat că inițierea GC sistemici a fost asociată cu o mortalitate mai mică la 28 de zile pentru toate cauzele la pacienții cu boală critică COVID-19. În consecință, OMS a emis două recomandări cu privire la tratamentul cu GC al pacienților cu COVID-19: 1) terapia cu GC sistemici trebuie inițiată la pacienții cu starea severă și critică, pentru care terapia este definită ca 6 mg/zi dexametazonă intern sau intravenos sau 50 mg de hidrocortizon intravenos la fiecare 8 ore, timp de 7 până la 10 zile; 2) utilizarea glucocorticoizilor în COVID-19 non-sever nu este recomandată [7].…”

Section: Materiale șI Metodeunclassified

“…Studiile observaționale sugerează că nivelurile crescute de proteină C-reactivă (PCR) și lactat dehidrogenază sunt predictori ai severității COVID-19. Corelații similare au fost stabilite pentru raportul crescut de neutrofile/limfocite, numărul scăzut de trombocite și numărul crescut de monocite CD14 + CD16 + și celule Th17 [7].…”

Section: Introducereunclassified

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Use of glucocorticoids in SARS CoV 2 infection: pros and cons

Bacinschi¹,

Ţurcan²,

Podgurschi³

et al. 2021

SPEMM

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Treatment of SARS CoV-2 infection is a major problem in contemporary medicine caused by the absence of specifi c antiviral drugs. Attempts to use many groups of drugs have had some successes and failures. Th e pathophysiological approach to the rationality of drug use is the basis of the eff ectiveness and safety of treatment. Glucocorticoids are a group of drugs capable of solving health problems in serious and critical situations. Physicians, despite the absence of evidence-based data, continue to use corticosteroids in critical situations based on pharmacological properties and experience. In SARS CoV-2 infection initially, at the beginning of the pandemic, the use of glucocorticoids was not recommended, and later, based on clinical studies, the World Health Organization issued a series of recommendations regarding the rationality of their use through an individualized approach. Th e latter involves determining the timing of initiation, selection of the drug, doses and duration of treatment. Th e key moment in this context is the time of the onset of the cytokine storm (the second week aft er the onset of symptoms) on which the administration of glucocorticoids is directed.

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Use of glucocorticoids in SARS CoV 2 infection: pros and cons

Bacinschi¹,

Ţurcan²,

Podgurschi³

et al. 2021

SPEMM

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“…3 Italian experience of acute severe inflammation and microvascular pathology as the causes of respiratory distress in COVID 19 disease resulted in alteration of treatment strategies towards glucocorticoid and anticoagulant administration in the management of COVID-19 disease. 4,5 https://doi.org/10.18231/j.ijirm.2021.021 2581-4214/© 2021 Innovative Publication, All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Study of biochemical haematological parameters in patients dying from COVID-19 in a tertiary care centre

Rachakonda¹,

Abburi²,

Gonuguntla³

et al. 2021

IJIRM

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COVID-19 pandemic resulted in a death of 419 patients among total admissions of 10682 with a death rate of 3.92% in the tertiary care COVID-19 hospital. We studied the biochemical and hematological parameters among 241 patients who died of the disease. CRP values were raised above 12mg/L in 58% of patients. 83% of patients had elevated LDH levels of >250 IU/L. Procalcitonin levels were above 0.5 microgram/L in nearly 66% of patients. Serum ferritin was more than 500 micrograms/L in 51% of patients. Elevated IL-6 were found in 83% of patients making it a significant inflammatory parameters. D-dimer levels were more than 500ng/ml in 74% of patients. HS Troponin I was raised in 83% of patients. Leukocytosis of more than 11000/Cu mm was seen in 38%. Leukopenia was seen in 35%. Thrombocytopenia was seen in 27% and normal platelet count was seen in 62%. Biochemical parameters help in assessing the severity of inflammation in COVID-19 disease. They aid in the process of treatment particularly anticoagulants and corticosteroid. Specific parameters like IL-6 can help in decision making by treating physician regarding the use of anti IL-6 drugs like Tocilizumab. Elevated HS troponin I in our study showed myocardial injury played a significant role in mortality of COVID 19 patients at our centre.

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“…GK'lerin eşdeğer dozları(17). GK'lerin metabolizma, hücre büyümesi, apoptozis üzerine etkileri olmakla birlikte, COVID-19 tedavisindeki katkıları muhtemelen immünsupresif özelliklerinden kaynaklanmaktadır(14,25). GK'lerin immün modülatuvar etkileri hücre tipine özeldir.…”

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Covid-19 Hastalarinda Korti̇kosteroi̇d Tedavi̇si̇: Ne Zaman Ve Nasil?

Çakır

2021

SDÜ Tıp Fakültesi Dergisi

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COVID-19 caused death of more than 2,7 million people all over the world since the first case seen in the Wuhan city of China. The primary causes of death due to COVID-19 are ARDS, sepsis and/or septic shock. There is no proven effective therapy for COVID-19 yet. It was considered that synthetic corticosteroids may be effective in the control of hyperinflammation and cytokine storm due to COVID-19 and clinical trials have shown that this group of drugs are effective in reducing mortality and the need of mechanical ventilation. World Health Organisation made a strong recommendation for systemic corticosteroid therapy

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The Role of Glucocorticoids in the Management of COVID-19

Cited by 41 publications

References 92 publications

Use of glucocorticoids in SARS CoV 2 infection: pros and cons

Use of glucocorticoids in SARS CoV 2 infection: pros and cons

COVID-19 Study of biochemical haematological parameters in patients dying from COVID-19 in a tertiary care centre

Covid-19 Hastalarinda Korti̇kosteroi̇d Tedavi̇si̇: Ne Zaman Ve Nasil?

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