The Role of Glucosamine and Chondroitin Sulfate in the Prevention of Colorectal Cancer: A Systematic Review

Khan, Asma A; Mannan, Vij; Pervaiz, Muhammad Ahad; Akram, Aqsa; Momin, Elina S; Sanusi, Muhammad; Kashyap, Tejasvi; Elshaikh, Abeer O

doi:10.7759/cureus.25401

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…For colorectal cancer, previous findings have been inconsistent. Four of seven studies in a latest systematic review reported significantly reduced risk of colorectal cancer incidence associated with glucosamine use, but the other three studies did not find statistical significance as in our analysis ( 17 ). In addition, our study suggested possible associations for the increased risk of melanoma and lower risk of kidney and thyroid cancers, although not statistically significant, which should be further investigated.…”

Section: Discussioncontrasting

confidence: 76%

Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort

Zhao

Lin

et al. 2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background:Previous studies indicated that glucosamine supplements may have a general anti-cancer effect. This study aimed to assess whether the potential effect differs across different types of cancers in a large prospective cohort study. Methods:All participants from the UK Biobank who were free of cancers and had complete information on glucosamine use at baseline were included and followed up from 2006 until 2021. Cox proportional hazards models were used to assess the associations between regular glucosamine use and different site-specific cancers. Subgroup analyses were performed to explore potential interactions. Several sensitivity analyses were conducted to assess the robustness of the main findings. Results:A total of 450,207 eligible participants (mean age: 56.2 years; females: 53.3%) were included, of whom 84,895 (18.9%) reported regular glucosamine use at baseline. During a median of 12.5 years follow-up, glucosamine use was significantly associated with an increased risk of overall cancer (HR=1.04, 95% CI: 1.01-1.06), skin cancer (HR=1.11, 95% CI: 1.07-1.15) and prostate cancer (HR=1.07, 95% CI: 1.01-1.13), and with a reduced risk of lung cancer (HR=0.88, 95% CI: 0.79-0.97) after adjusting for potential confounders. Statistical interaction was observed for gender, age and education for the association of glucosamine use with overall cancer risk (all P-interaction <0.027). These results remained unchanged in the sensitivity analysis. Conclusions:Regular glucosamine use was associated with lower risk of lung cancer but higher risk of skin cancer, prostate cancer and overall cancer. Impact:The roles of glucosamine use potentially differ in the development of different site-specific cancers.

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Section: Discussioncontrasting

confidence: 76%

Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort

Zhao

Lin

et al. 2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…However, weight gain was reported in those who consumed the supplement more frequently or simultaneously used non-steroidal anti-inflammatory drugs. However, this study did not confirm which drug was responsible for the weight gain [ 96 ]. Therefore, it is suggested that consuming CS more than the recommended dose should be avoided.…”

Section: Prospective Pharmacological Applicationmentioning

confidence: 99%

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

Urbi

Azmi

Ming

et al. 2022

CIMB

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Chondroitin sulphate (CS) is one of the most predominant glycosaminoglycans (GAGs) available in the extracellular matrix of tissues. It has many health benefits, including relief from osteoarthritis, antiviral properties, tissue engineering applications, and use in skin care, which have increased its commercial demand in recent years. The quest for CS sources exponentially increased due to several shortcomings of porcine, bovine, and other animal sources. Fish and fish wastes (i.e., fins, scales, skeleton, bone, and cartilage) are suitable sources of CS as they are low cost, easy to handle, and readily available. However, the lack of a standard isolation and characterization technique makes CS production challenging, particularly concerning the yield of pure GAGs. Many studies imply that enzyme-based extraction is more effective than chemical extraction. Critical evaluation of the existing extraction, isolation, and characterization techniques is crucial for establishing an optimized protocol of CS production from fish sources. The current techniques depend on tissue hydrolysis, protein removal, and purification. Therefore, this study critically evaluated and discussed the extraction, isolation, and characterization methods of CS from fish or fish wastes. Biosynthesis and pharmacological applications of CS were also critically reviewed and discussed. Our assessment suggests that CS could be a potential drug candidate; however, clinical studies should be conducted to warrant its effectiveness.

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“…The relevant studies were screened, distilled, and collected by two independent researchers, anonymously through the Rayyan Software (Rayyan Systems Inc., Cambridge, Massachusetts) [ 16 ]. The intervention and outcome were carefully and closely monitored and extracted.…”

Section: Reviewmentioning

confidence: 99%

Efficacy of Semaglutide in Treating Obesity: A Systematic Review of Randomized Controlled Trials (RCTs)

Anam¹,

Maharjan²,

Amjad³

et al. 2022

Cureus

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Obesity is a major health problem worldwide resulting in numerous health conditions such as heart disease, stroke, type 2 diabetes (T2D), and certain types of cancer which are among the leading causes of premature preventable deaths. Recently, glucagon like peptide-1 receptor agonists (GLP-1 RA) has been identified as the most promising intervention in treating obesity. Our systematic review aims to analyze the efficacy of semaglutide, a GLP-1RA in treating obesity. We searched PubMed, Science Direct, and Google Scholar databases to review and distill full-text articles based on the eligibility criteria and involved 12 papers of clinical trials. The review found that semaglutide is safe and effective in treating obesity, and complications reported were primarily gastrointestinal events. Further exploration with more number of clinical trials involving greater sample size and lengthier time of follow-up is essential to determine its efficacy and safety in a diverse group of individuals who are overweight or obese and the dose required along with the duration of treatment.

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The Role of Glucosamine and Chondroitin Sulfate in the Prevention of Colorectal Cancer: A Systematic Review

Cited by 3 publications

References 26 publications

Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort

Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

Efficacy of Semaglutide in Treating Obesity: A Systematic Review of Randomized Controlled Trials (RCTs)

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