The Aim of this Study is the Green Biosynthesis of Zinc Oxide Nanoparticles (ZnO NPS) Using Pomegranate Peel Extract Utilized from Fruit Waste. Zno Nps were Characterized by X-Ray Powder Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray (EDX), Fourier Transform Infrared (FT-IR) Spectrum and UV–Vis Spectrophotometry. Also, Evaluation of the Efficiency of the Prepared Zno Nps Using the Jar Test Procedure was Employed after the Determination of the Optimum Dose of Zno Nps for the Removal of Pollutants from the Grey Water. Different Doses of Zno Nanoparticles (0.05, 0.1, 0.2, 0.3, 0.4, and 0.5 g/L) were Examined. the Results Obtained Confirmed that Zno Nps are Large Particles in Size Ranging from 54.2 to 86.4 Nm, Exist in a Pure and Crystalline Phase. the Results Obtained Showed that the Efficiency of Zno Nps for Pollutant Removal from Grey Water was Increased with the Increase of the Adsorbent Dose. the Best Removal Efficiency of Zno Nps was Obtained at a Dose of 400 Mg/L. the Removal Efficiency of Zno NPS was 98.16 %, 88.68%, 100%, 94.40%, 97.88%, 91.18%, 89.13%, 90.93%, and 90.37% for Ammonia (NH3+), Phosphorous (PO43-), Nitrate (NO3-), Oil & Grease, Total Nitrogen (TN), Turbidity, Chemical Oxygen Demand (COD), Biological Oxygen Demand (BOD5), and Total Suspended Solids (TSS) Removal, Respectively. the Cost Required for the Production of 100 g of Zno Nps was Calculated and Estimated to Be 42.37 Egyptian Pounds. in Conclusion Zno Nps Synthesized from Pomegranate Waste is a Sustainable, Eco-Friendly and Cost-Effective Approach with Potent Efficiency for Pollutants Removal from Grey Water.