The role of group 3 innate lymphoid cell in intestinal disease

Li, Minghui; Wang, Zehui; Jiang, Wei; Lu, Yihan; Zhang, Jun

doi:10.3389/fimmu.2023.1171826

Cited by 8 publications

(2 citation statements)

References 165 publications

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“…Therefore, SETD2 also indirectly contributes to intestinal homeostasis by influencing intestinal immunity. 44 …”

Section: Mainmentioning

confidence: 99%

The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer

Larue,

Atlasi

2024

Stem Cells

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Epigenetic mechanisms play a pivotal role in controlling gene expression and cellular plasticity in both normal physiology and pathophysiological conditions. These mechanisms are particularly important in the regulation of stem cell self-renewal and differentiation, both in embryonic development and within adult tissues. A prime example of this finely tuned epigenetic control is observed in the gastrointestinal lining, where the small intestine undergoes renewal approximately every 3-5 days. How various epigenetic mechanisms modulate chromatin functions in intestinal stem cells (ISCs) is currently an active area of research. In this review, we discuss the main epigenetic mechanisms that control ISC differentiation under normal homeostasis. Furthermore, we explore the dysregulation of these mechanisms in the context of colorectal cancer (CRC) development. By outlining the main epigenetic mechanisms contributing to CRC, we highlight the recent therapeutics development and future directions for colorectal cancer research.

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“…Therefore, SETD2 also indirectly contributes to intestinal homeostasis by influencing intestinal immunity. 44 …”

Section: Mainmentioning

confidence: 99%

The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer

Larue,

Atlasi

2024

Stem Cells

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“…Indeed, it has been shown that murine norovirus (MNV) is capable of restoring architectural and immune status during gut bacterial dysbiosis [105]. The researchers hypothesized that the mechanism regulating host immune homeostasis in the GI tract was correlated with lymphocyte cell upregulation paired with IFNγ production and IgA release, allowing balance of type 2 and 3 innate lymphoid cell (ILC) ratios [106]. Interestingly, this also occurred during infection or inflammation, highlighting the possible protective role that some enteric viruses may play [107].…”

Section: Eukaryotic Viruses and The Gut Mucosal Immune Systemmentioning

confidence: 99%

Does the Human Gut Virome Contribute to Host Health or Disease?

Pavia,

Marascio,

Matera

et al. 2023

Viruses

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The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”. This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome’s composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies.

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Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Xu,

Shao,

Fang

et al. 2024

Exploration

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Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on individuals and society. While the conventional use of immunosuppressants and disease‐modifying drugs has provided partial relief and control, their inevitable side effects and limited efficacy cast a shadow over finding a cure. Promising nucleic acid drugs have shown the potential to exert precise effects at the molecular level, with different classes of nucleic acids having regulatory functions through varying mechanisms. For the better delivery of nucleic acids, safe and effective viral vectors and non‐viral delivery systems (including liposomes, polymers, etc.) have been intensively explored. Herein, after describing a range of nucleic acid categories and vectors, we focus on the application of therapeutic nucleic acid delivery in various IMIDs, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, asthma, ankylosing spondylitis, systemic lupus erythematosus, and uveitis. Molecules implicated in inflammation and immune dysregulation are abnormally expressed in a series of IMIDs, and their meticulous modulation through nucleic acid therapy results in varying degrees of remission and improvement of these diseases. By synthesizing findings centered on specific molecular targets, this review delivers a systematic elucidation and perspective towards advancing and utilization of nucleic acid therapeutics for managing IMIDs.

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The role of group 3 innate lymphoid cell in intestinal disease

Cited by 8 publications

References 165 publications

The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer

The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer

Does the Human Gut Virome Contribute to Host Health or Disease?

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

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