The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Shan, Lingyue; Tyagi, Akanksha; Shabbir, Umair; Chen, Xiuqin; Vijayalakshmi, S.; Yan, Pianpian; Oh, Deog‐Hwan

doi:10.3390/fermentation8080376

Cited by 8 publications

(9 citation statements)

References 90 publications

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“…Some research indicates that the gut microbiota can influence insulin sensitivity. [ 17 ] Modulating the gut microbiota may impact insulin resistance through various mechanisms, including the production of bioactive compounds and the regulation of inflammation. [ 17 ]…”

Section: Methodsmentioning

confidence: 99%

“…Comprehensive risk-benefit assessments, robust post-market surveillance, and adherence to the stringent quality standards could help eliminate the risks and to extract the immense therapeutic benefits from microbiota modulation across different patient populations. [ 17 ] The constantly changing scenario of microbiota manipulation brings in an era of great inventions, which are used for the treatment of a lot of diseases and health conditions. In the future, microbiome-based therapies, phage therapy, microbiome engineering, and the making of microbiota-targeted drugs will be among the directions for research.…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

Ugwu,

Alum,

Okon

et al. 2024

Medicine

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Microbiota modulation, the intentional change in the structure and function of the microbial community, is an emerging trajectory that holds the promise to mitigate an infinite number of health issues. The present review illustrates the underlying principles of microbiota modulation and the various applications of this fundamental process to human health, healthcare management, and pharmacologic interventions. Different strategies, directing on dietary interventions, fecal microbiota transplantation, treatment with antibiotics, bacteriophages, microbiome engineering, and modulation of the immune system, are described in detail. This therapeutic implication is reflected in clinical applications to gastrointestinal disorders and immune-mediated diseases for microbiota-modulating agents. In addition to this, the review outlines the challenges of translating researched outcomes into clinical practice to consider safety and provides insights into future research directions of this rapidly developing area.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

Ugwu,

Alum,

Okon

et al. 2024

Medicine

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“…13,15,17 Many review studies have shed light on different topics related to gut microbiota and obesity in the last 5 years. 8,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] However, there is still a lack of updated compilation of available data on the potential role of gut microbiota in obesity, particularly regarding dietary factors as a therapeutic approach. Therefore, this review aims to present a comprehensive and updated overview of the potential role of gut microbiota in obesity, with a special focus on dietary factors, particularly diet, prebiotics, and probiotics, as potential therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

“…Although various factors can cause variations in bacterial communities (Figure 1), 14–16 there is increasing evidence that dietary modifications may be enormously effective for modulating gut microflora 13,15,17 . Many review studies have shed light on different topics related to gut microbiota and obesity in the last 5 years 8,18–36 . However, there is still a lack of updated compilation of available data on the potential role of gut microbiota in obesity, particularly regarding dietary factors as a therapeutic approach.…”

Section: Introductionmentioning

confidence: 99%

The gut microbiome in the fight against obesity: The potential of dietary factors

Ahmad,

Khan,

Zengin

et al. 2023

The FASEB Journal

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Obesity as a global public health burden has experienced a drastic growing trend recently. The management of obesity is challenging because of its complex etiology, and various factors are involved in its development, such as genetic and environmental factors. Different approaches are available to treat and/or manage obesity, including diet, physical activity, lifestyle changes, medications, and surgery. However, some of these approaches have inherent limitations and are closely associated with adverse effects. Therefore, probing into a novel/safe approach to treat and/or manage obesity is of fundamental importance. One such approach gaining renewed interest is the potential role of gut microbiota in obesity and its effectiveness in treating this condition. However, there is a dearth of comprehensive compilation of data on the potential role of the gut microbiome in obesity, particularly regarding dietary factors as a therapeutic approach. Therefore, this review aims to provide an updated overview of the role of gut microbiota in obesity, further highlighting the importance of dietary factors, particularly diet, prebiotics, and probiotics, as potential complementary and/or alternative therapeutic options. Moreover, the association of gut microbiota with obese or lean individuals has also been discussed.

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“…SCFA has shown beneficial effects on the host metabolism, normalising glucose level and reducing plasma levels of cholesterol 7. Studies on mice have shown that increased production of SCFA by decreased Bacteroidetes and increased Firmicutes can promote obesity by increasing colonic energy availability 8. A difference in gut bacterial composition between people with severe obesity and normal weight has been shown in several studies 9 10.…”

Section: Introductionmentioning

confidence: 99%

Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol

Hanssen,

Fjellstad,

Skjevling

et al. 2023

BMJ Open

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IntroductionObesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve several obesity comorbidities. Options are conservative treatment such as lifestyle changes, bariatric surgery or medications. Conservative treatment has a low success rate, and bariatric surgery is typically not reversible, with the risk of complications and recurrences. Treatment of obesity with medications has in recent years shown great promise, but the side effects are many, and the long-term effect is unknown. There is also a need for an option for patients where surgery has contraindications and conservative follow-up does not succeed.The research on obesity and gut microbiota has yielded promising results regarding weight reduction and metabolic health, but more research is needed to better understand the relationship between gut microbiota and severe obesity. This study could show proof of concept that gut microbiota from a lean donor could, in addition to lifestyle intervention, contribute to weight reduction in people suffering from severe obesity.Method and analysisThis study aims to investigate if a fecal microbiota transplantation (FMT) from a lean donor leads to weight reduction in participants suffering from severe obesity. The study is a single-centre, double-blinded, placebo-controlled, parallel-group study with 60 participants. Participants will be randomised 1:1 for FMT from a lean donor or placebo. FMT or placebo will be delivered once by enema.We will include participants from the outpatient clinic for severe obesity, at the Medical Department, University Hospital of North Norway, Harstad, by invitation only. The study has a follow-up period of 12 months, with study visits of 3, 6 and 12 months post FMT. The primary endpoint is a weight reduction of ≥10%, 12 months after intervention.The results of the study will be published in open access journals. At the end of the study, the participants will receive information on which treatment group they belong to.Ethics and disseminationThe Regional Ethical Committee in North Norway (REK) approved the study protocol (2017/1655/REK Nord). We plan to present the results from the study at (inter)national conferences and publish in open-access general peer-reviewed journals. The enema method for FMT administration used in this study was developed by our study team.Trial registration numberNCT03273855.

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The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Cited by 8 publications

References 90 publications

Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

The gut microbiome in the fight against obesity: The potential of dietary factors

Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol

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