The role of gut microbiota in the pathogenesis and treatment of acute pancreatitis: a narrative review

Lu, Weiwei; Chen, Xi; Ni, Jian-Li; Shi, Zhu; Fei, Aihua; Wang, Xiaosu

doi:10.21037/apm-21-429

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…These are live microorganisms that confer a health benefit through the inhibition of pathogenic microorganisms, the induction of growth of the mucous layer, and inhibiting apoptosis of epithelial cells. The most used probiotics are Lactobacillus, Bifidobacterium, Streptococcus, and Lactococcus lactis among others [125,126]. Other strategies as antibiotics are not widely used in patients with AP since their prophylactic use does not reduce mortality, and in spite of this, Ahuja et al [127] reported that the pancreatic acini were able to regulate the intestinal microbiota through the secretion of antimicrobials and different pro-inflammatory cytokines, which still must be proven.…”

Section: Gut Microbiome Impact In Apmentioning

confidence: 99%

Advances in Nutritional Therapy of Acute Pancreatitis

Chávez-Tostado¹,

Chávez-Tostado²,

González-Ojeda³

et al. 2023

Multidisciplinary Management of Acute and Chronic Pancreatitis

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Acute pancreatitis (AP) is a frequent abdominal acute inflammatory disorder and the leading cause of hospital admissions in gastrointestinal units. Clinical manifestations of AP vary from a mild edematous form to severe fulminant pancreatitis with major devastating complications. To date, experimental therapeutic agents remain scarce for the treatment of this disease. Nutritional therapy with appropriate nutrient supplementation is key to limiting the acute inflammation and preventing and managing complications associated with AP. This chapter focuses on novel therapeutic agents for nutritional intervention including enteral versus parenteral nutrition strategies, and nutritional supplements such as probiotics, glutamine, omega-3 fatty acids, and vitamins in the treatment of AP.

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Section: Gut Microbiome Impact In Apmentioning

confidence: 99%

Advances in Nutritional Therapy of Acute Pancreatitis

Chávez-Tostado¹,

Chávez-Tostado²,

González-Ojeda³

et al. 2023

Multidisciplinary Management of Acute and Chronic Pancreatitis

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“…Их появление связано со снижением уровней воспалительных цитокинов, таких как IL-1-бета, TNF-альфа, CXCL1 и IL-18, и обратно коррелирует с тяжестью панкреатита и системными инфекционными осложнениями. С клинической точки зрения восстановление физиологического состава микробиоты кишечника может быть полезной стратегией для лечения острого панкреатита [48,69,73,139]. Qin и соавт.…”

Section: Issn 2221-2582unclassified

Gut Microbiota and Pancreatic Diseases

Комиссарова

2023

Children's Medicine of the North-West

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В обзоре представлены научные данные об особенностях и механизмах формирования кишечной микробиоты при различных заболеваниях поджелудочной железы, а также факторах, влияющих на хронический воспалительный процесс. This review presents scientifi c data on the features and mechanisms of the formation of gut microbiota in various pancreatic diseases, as well as factors aff ecting chronic infl ammatory processes.

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“…It has been found that mastitis in mice leads to a disturbance in their intestinal microbiota, increasing the number of pathogenic bacteria and decreasing the number of beneficial flora in the gut ( Guo et al, 2020 ). One study analysed fecal 16S rDNA diversity in 130 patients with acute pancreatitis and 35 healthy subjects, found that the structure of the gut microbiota was significantly different between the two study groups and was closely related to the systemic inflammatory response and impaired intestinal barrier and the abundance of beneficial bacteria such as blautia was significantly lower in severe patients than in mild and moderate patients ( Lu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Total flavonoids of Abrus cantoniensis inhibit CD14/TLR4/NF-κB/MAPK pathway expression and improve gut microbiota disorders to reduce lipopolysaccharide-induced mastitis in mice

Sun

Zhang

et al. 2022

Front. Microbiol.

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Established a model of lipopolysaccharide (LPS)-induced mastitis in mice, pathological sections and myeloperoxidase were used to detect the degree of tissue damage, enzyme-linked immunosorbent assay (ELISA) was performed to detect the expression of pro-inflammatory cytokines, meanwhile fluorescence quantitative PCR experiments were performed to detect the mRNA expression of CD14/TLR4/NF-κB/MAPK signalling pathway, and the faeces of mice were collected for 16S measurement of flora. The results showed that Abrus cantoniensis total flavonoids (ATF) could significantly reduce the damage of LPS on mammary tissue in mice and inhibit the secretion of inflammatory factors such as TNF-α, IL-1β and IL-6. At the mRNA level, ATF inhibited the expression of CD14/TLR4/NF-κB/MAPK pathway and enhanced the expression of tight junction proteins in the blood-milk barrier. In the results of the intestinal flora assay, ATF were found to be able to regulate the relative abundance of the dominant flora from the phylum level to the genus level, restoring LPS-induced gut microbial dysbiosis. In summary, ATF attenuated the inflammatory response of LPS on mouse mammary gland by inhibiting the expression of CD14/TLR4/NF-κB/MAPK pathway, enhancing the expression of tight junction proteins and restoring LPS-induced gut microbial dysbiosis. This suggests that ATF could be a potential herbal remedy for mastitis.

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The role of gut microbiota in the pathogenesis and treatment of acute pancreatitis: a narrative review

Cited by 20 publications

References 34 publications

Advances in Nutritional Therapy of Acute Pancreatitis

Advances in Nutritional Therapy of Acute Pancreatitis

Gut Microbiota and Pancreatic Diseases

Total flavonoids of Abrus cantoniensis inhibit CD14/TLR4/NF-κB/MAPK pathway expression and improve gut microbiota disorders to reduce lipopolysaccharide-induced mastitis in mice

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