The Role of Halothane in the Prevention of Surgical Shock

Johnstone, Michael

doi:10.1093/bja/30.9.435

Cited by 15 publications

(4 citation statements)

References 41 publications

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“…It is hard to make a case for it, although there have been attempts to do SO. 44 The difficulty sterns from having to argue that weakening a powerful compensatory mechanism can somehow increase Price the chance of survival under unfavorable conditions. Several responses to cyclopropane appear at the opposite pole from those evoked by halothane.…”

Section: Resultsmentioning

confidence: 99%

Circulatory actions of general anesthetic agents and the homeostatic roles of epinephrine and norepinephrine in man

Price

1961

Clin Pharma and Therapeutics

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Circulatory actions of general anesthetic agents are viewed as resulting from three primary causes: (1) reduced metabolic demand resulting in turn from anesthetie depression of cellular activity throughout the body, (2) redueed functional ability of the heart and vasculature caused by direct anesthetic actions on these structures, and (3) autonomic nervous actions which modify cardiovascular regulation. Hemodynamic changes attributable to redueed metaholie demand represent normal homeostatie responses, but those caused by anesthetic depression of cardiovaseular struetures or reflexes tend to destroy homeostasis and are potentially lethal. It is signifieant that eaeh of the four general anestheties most eommonly used in man has been found to disturb cardiovascular regulation, and it may be assumed that all such drugs possess side effects of this type. However, it is important as well as interesting that eaeh of the drugs examined evokes a eharaeteristie mixture of hemodynamie and autonomic actions which is distinct trom that caused by any other. This suggests that circulatorY side actions may ultimately be predictable trom drug structure and that an ability to design anesthetics with desirable circulatory actions will prove worthy of cultivation.

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Section: Resultsmentioning

confidence: 99%

Circulatory actions of general anesthetic agents and the homeostatic roles of epinephrine and norepinephrine in man

Price

1961

Clin Pharma and Therapeutics

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“…It is this end-product which the anaesthetist is concerned to abolish by the "depression of undesirable reflex responses to injury". Johnstone (1958) has laid the main responsibility for the initiation of the physiological train of events whose end result is the shocked patient, on the vasomotor section of the sympathetic system. He favours the control and limitation of shock by the paralysis of the efferent side of this system through the readily reversible action of halothane.…”

Section: The Depression Of Undesirable Reflex Responsesmentioning

confidence: 99%

Extradural Block in Major Surgery of the Hip

Hill¹,

Wharton²,

Delaney³

1962

British Journal of Anaesthesia

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“…There is little experience of the use of halothane in the presence of surgical shock, but there is, as yet, no evidence to suggest that it is any more harmful than any other general anaesthetic agents. Wyman (1953) and Johnstone (1958) consider that vasodilatation is, in fact, beneficiala view shared by many anaesthetists.…”

Section: Care and Maintenancementioning

confidence: 99%

Portable Anaesthetic Apparatus for Use in the Antarctic

Nunn¹

1961

BMJ

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The Role of Halothane in the Prevention of Surgical Shock

Cited by 15 publications

References 41 publications

Circulatory actions of general anesthetic agents and the homeostatic roles of epinephrine and norepinephrine in man

Circulatory actions of general anesthetic agents and the homeostatic roles of epinephrine and norepinephrine in man

Extradural Block in Major Surgery of the Hip

Portable Anaesthetic Apparatus for Use in the Antarctic

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