The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities

Fu, Xun; Liu, Huan; Liu, Jiang; DiSanto, Michael E.; Zhang, Xinhua

doi:10.3390/cells11132052

Cited by 8 publications

(9 citation statements)

References 128 publications

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“…Therefore, the level of endogenous Hsp70 in cells is used, not only as a biomarker of various diseases but also to monitor the results of therapy for various human diseases [139,140]. In particular, Hsp70 levels have been used as a biomarker of prostate diseases and bronchopulmonary dysplasia (BPD) for targeted therapies [135,141]. Thus, it is known that Hsp70 levels are associated with a state of oxidative injury in the development of BPD [135].…”

Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

“…Administration of recHsp70 in different ways led to positive therapeutic effects when used in vitro and animal models for such different diseases and pathologies as diabetes, prostatitis, and various forms of lung damage, including various forms of fibrosis [135,137,141,170]. RecHsp70 administration also resulted in a reduction of cholesterol levels in human cells and model animals [171].…”

Section: The Use Of Recombinant Hsp70 In Model Experiments and Clinic...mentioning

confidence: 99%

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The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Evgen’ev¹,

Onikienko²,

Chuvakova³

et al. 2023

Front. Biosci. (Landmark Ed)

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In the present era of global warming and dramatically increased environmental pollution posing a threat to animal life, the understanding and manipulation of organisms' resources of stress tolerance is apparently a question of survival. Heat stress and other forms of stressful factors induce a highly organized response of organisms at the cellular level where heat shock proteins (Hsps) and in particular Hsp70 family of chaperones are among the major players in the protection from the environmental challenge. The present review article summarizes the peculiarities of the Hsp70 family of proteins protective functions being a result of many millions of years of adaptive evolution. It discusses the molecular structure and specific details of hsp70 gene regulation in various organisms, living in diverse climatic zones, with a special emphasis on the protective role of Hsp70 in adverse conditions of the environment. The review discusses the molecular mechanisms underlying Hsp70-specific properties that emerged in the course of adaptation to harsh environmental conditions. This review also includes the data on the anti-inflammatory role of Hsp70 and the involvement of endogenous and recombinant Hsp70 (recHsp70) in proteostatic machinery in various pathologies including neurodegenerative ones such as Alzheimer's and Parkinson's diseases in rodent model organisms and humans in vivo and in vitro. Specifically, the role of Hsp70 as an indicator of disease type and severity and the use of recHsp70 in several pathologies are discussed. The review discusses different roles exhibited by Hsp70 in various diseases including the dual and sometimes antagonistic role of this chaperone in various forms of cancer and viral infection including the SARS-Cov-2 case. Since Hsp70 apparently plays an important role in many diseases and pathologies and has significant therapeutic potential there is a dire need to develop cheap recombinant Hsp70 production and further investigate the interaction of externally supplied and endogenous Hsp70 in chaperonotherapy.

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Section: Hsp70 As a Biomarker Of Pathological Processes And Diseasesmentioning

confidence: 99%

Section: The Use Of Recombinant Hsp70 In Model Experiments and Clinic...mentioning

confidence: 99%

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Evgen’ev¹,

Onikienko²,

Chuvakova³

et al. 2023

Front. Biosci. (Landmark Ed)

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show abstract

“…The two domains are connected by a linker ( Figure 2 a). The N-terminal NBD provides ATP/ADP pockets for ATP binding, which is critical for the ATPase reaction that is required for protein folding and release [ 8 ]. HSP70 binding protein 1(HSPBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of HSP70s, catalyze the release of ADP from HSP70s while inducing different conformational changes in the ATPase domain of HSP70s.…”

Section: Hsp Familymentioning

confidence: 99%

“…The binding and dissociation of substrates are necessary for HSP70 family members to fold substrates. Allosteric effects between functional domains modulate the ATPase cycle, in turn, polypeptide uptake and release by HSP70s [ 8 , 40 ].…”

Section: Hsp Familymentioning

confidence: 99%

“…On a cellular level, HSP70s and HSP90s are involved in chaperone activity, protein folding, cell survival and proliferation, cell apoptosis, autophagy, cell differentiation, epithelial–mesenchymal transition (EMT), fibrosis, DNA repair, etc. [ 8 , 9 , 10 , 11 , 12 ] ( Figure 1 ), contributing to the initiation, development and progression of prostate cancer. Based on the functions of HSP70s and HSP90s in tumorigenesis, a number of agents targeting the critical structure of two molecular families have been successfully developed.…”

Section: Introductionmentioning

confidence: 99%

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Heat Shock Protein 70 and 90 Family in Prostate Cancer

Liu

Yan

et al. 2022

Life

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Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and protect cancer cells from death. On a cellular level, HSP molecules have a strong relationship with multiple important biological processes, such as cell differentiation, epithelial–mesenchymal transition (EMT), and fibrosis. Because of the facilitation of HSP family molecules on tumorigenesis, a number of agents and inhibitors are being developed with potent antitumor effects whose target site is the critical structure of HSP molecules. Among all target molecules, HSP70 family and HSP90 are two groups that have been well studied, and therefore, the development of their inhibitors makes great progress. Only a small number of agents, however, have been clinically tested in recruited patients. As a result, more clinical studies are warranted for the establishment of the relationship between the HSP70 family, alongside the HSP90 molecule, and prostate cancer treatment.

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STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia

Liu,

Zhou,

Yang

et al. 2024

Cellular Signalling

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The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities

Cited by 8 publications

References 128 publications

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Heat Shock Protein 70 and 90 Family in Prostate Cancer

STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia

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