The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation

Multhoff, Gabriele; Pockley, A. Graham; Schmid, Thomas E.; Schilling, Daniela

doi:10.1016/j.canlet.2015.02.013

Cited by 105 publications

(93 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Notably, ionizing radiation also indirectly regulates NK cell mediated tumor cell lysis and anti-tumor response. This effect was triggered by an increased expression of NK recognition structures such as heat shock protein (Hsp)70 or NKG2D receptors [48] on the surface of, or by the Hsp70 release from, the dying tumor cells, respectively [49,50]. Combined treatments of cell based NK cell therapy and RT are at an early stage [51,52].…”

Section: Activation Of Nk Cells Is Modulated By Ionizing Radiationmentioning

confidence: 98%

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

et al. 2015

View full text Add to dashboard Cite

Section: Activation Of Nk Cells Is Modulated By Ionizing Radiationmentioning

confidence: 98%

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

et al. 2015

View full text Add to dashboard Cite

“…It is therefore essential to ensure that reagents and experimental design(s) are beyond question when it comes to undertaking experiments in this area. The influence of heat shock proteins on immune responses in a number of contexts has been reviewed elsewhere (64)(65)(66) …”

Section: Cell Stress Proteins As Immunomodulatory Mediatorsmentioning

confidence: 99%

Extracellular cell stress (heat shock) proteins—immune responses and disease: an overview

Pockley

Henderson

2017

Phil. Trans. R. Soc. B

118

View full text Add to dashboard Cite

Contribution to a theme issue 'Heat shock proteins in health and disease: integrating knowledge to better understand the role of heat shock proteins as therapeutic targets and disease modulators' Keywords:Heat shock (stress) proteins, extracellular, immunity Author for correspondence:A. Graham Pockley, PhD e-mail: graham.pockley@ntu.ac.ukHeat shock proteins in health and disease: integrating knowledge to better understand the role of heat shock proteins as therapeutic targets and disease modulators 2 | P a g e Abstract Extracellular cell stress proteins are highly conserved phylogenetically and have been shown to act as powerful signalling agonists and receptors for selected ligands in several different settings. They also act as immunostimulatory "danger signals" for the innate and adaptive immune systems. Other studies have shown that cell stress proteins and the induction of immune reactivity to self-cell stress proteins can attenuate disease processes. Some proteins (e.g. Hsp60, Hsp70, gp96) exhibit both inflammatory and anti-inflammatory properties, depending on the context in which they encounter responding immune cells.The burgeoning literature reporting the presence of stress proteins in a range of biological fluids in healthy individuals / non-diseased settings, the association of extracellular stress protein levels with a plethora of clinical and pathological conditions and the selective expression of a membrane form of Hsp70 on cancer cells now supports the concept that extracellular cell stress proteins are involved in maintaining / regulating organismal homeostasis and in disease processes and phenotype. Cell stress proteins therefore form a biologically complex extracellular cell stress protein network having diverse biological, homeostatic and immunomodulatory properties, the understanding of which offers exciting opportunities for delivering novel approaches to predict, identify, diagnose, manage and treat disease.Heat shock proteins in health and disease: integrating knowledge to better understand the role of heat shock proteins as therapeutic targets and disease modulators 3 | P a g e 1. Background 'Chance favours the prepared mind ' -Louis Pasteur (1822 -1895 The presence of additional new 'puffs' in the polytene chromosomes of cultured Drosophila larva which were induced following their incubation at an inadvertently high temperature and observed by Ferruccio Ritossa (25 th February 1936 -9 th January 2014) in the early 1960s was unexpected and puzzling. He realised the potential importance of this first evidence that stress can influence gene transcription and induce the synthesis of new proteins, yet found it surprisingly difficult to publish this discovery. It was eventually published in Experientia (1, 2).Ritossa's findings were extended and expanded upon during the next decade and by the mid-to-late 1960s it was clear that exposure of cells containing polytene chromosomes to a variety of environmental stressors resulted in the transcription of novel genes and, presumably, in the synthesi...

show abstract

“…On the other hand, in our study spinosad application caused a significant increase in HSP70 concentration in the body of the insects from the Cd-strain in comparison to the insects from the control strain. Enhanced synthesis of heat shock proteins is, in general, regarded as a protective mechanism against environmental stress (Multhoff et al 2015;Sandbichler and Höckner 2016). However, the reports can be found presenting examples of adapted ecotypes of invertebrates, that are insensitive to pollutants, including cadmium, and, at the same time, they have low HSP concentration (Haap and Köhler 2009;Haap et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Cross tolerance in beet armyworm: long-term selection by cadmium broadens tolerance to other stressors

et al. 2017

View full text Add to dashboard Cite

Long lasting exposure of animals to stressing factor may lead to the selection of population able to cope with the stressor at lower cost than unexposed individuals. The aim of this study was to assess whether 130-generational selection of a beet armyworm to cadmium in food might have induced tolerance also to other stressors. The potential tolerance was assessed by means of unspecific stress markers: HSP70 concentration, DNA damage level, and energy budget indices in L5 larval instars of beet armyworm. The animals originated from Cd-exposed and control strains exposed additionally in a short-term experiment to high/low temperature or pesticide-spinosad. The application of the additional stressors caused, in general, an increase in the levels of studied parameters, in a straindependent manner. The most significant increase was found in HSP70 level in the individuals from the Cd-strain exposed to various spinosad concentration. Therefore, multigenerational contact with cadmium caused several changes that enable the insect to survive under a chronic stress, preparing the organism to the contact with an additional, new stressor. This relationship may be described as a sort of cross tolerance. This may, possibly, increase the probability of population survivorship and, at the same time, decrease the efficiency of pesticide-based plant protection efforts.

show abstract

The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation

Cited by 105 publications

References 102 publications

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

Extracellular cell stress (heat shock) proteins—immune responses and disease: an overview

Cross tolerance in beet armyworm: long-term selection by cadmium broadens tolerance to other stressors

Contact Info

Product

Resources

About