The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease

Israel, Dawn A.; Peek, Richard M.

doi:10.1007/978-0-387-69182-4_16

Cited by 1 publication

(1 citation statement)

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“…The infectious agent Helicobacter pylori is intimately associated with the most common types of gastric adenocarcinoma development [ 102 ]. H. pylori colonizes the stomach of at least half the world's population, virtually all persons infected with H. pylori develop gastric inflammation, which confers an increased risk for developing gastric cancer; however, only a fraction of infected individuals develop the clinical disease [ 103 ]. H. pylori induces generalized mutation and genomic instability in host DNA [ 104 ], which along with the complex risk profile suggests diverse routes to oncogenesis in gastric adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

Holbrook

Parker²,

Gallagher

et al. 2011

J Transl Med

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BackgroundGlobally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.MethodsHere, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers.ResultsGenetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways.ConclusionsThe data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.

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Section: Discussionmentioning

confidence: 99%