The role of Helicobater pylori as an aetiological factor for rosacea

Ghanem, Bothaina Mahrous; Elkholy, Ayman; El-Ghawalby, Nabih; Elchennawy, Farha A.; Naby, Samia M Abdel

doi:10.4103/ejdv.ejdv_60_16

Cited by 1 publication

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“…For example, Bothaina et al . [ 29 ] found earlier and more marked improvement in rosacea in negative (75%) patients than still positive patients for H. pylori . Furthermore, in the study by Tampouratzi et al .…”

Section: Discussionmentioning

confidence: 99%

Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection

Hejazi¹,

Aghaei²,

Aghaei³

et al. 2023

Advanced Biomedical Research

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Background: Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, Helicobacter pylori have been suggested in rosacea progression. The present study investigated the relationship between H. pylori eradication and rosacea patient's improvement. Materials and Methods: H. pylori infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for H. pylori eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of P < 0.05. Results: At the baseline, the mean of immunoglobulin G (IgG) (59.27 ± 41.4 RU/mL) and immunoglobulin M (IgM) (11.55 ± 6.1 RU/mL) in rosacea patients was higher than the level of IgG (41.38 ± 54.33 RU/mL) and IgM (8.11 ± 8.91 RU/mL) in healthy control ( P < 0.04) and ( P < 0.01), respectively. Also, the values for H. pylori infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after H. pylori eradication. Conclusion: Data suggest the exacerbating role of H. pylori in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement.

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Section: Discussionmentioning

confidence: 99%