The Role of Hepatic Liver X Receptor α-and Sterol Regulatory Element Binding Protein-1c-Mediated Lipid Disorder in the Pathogenesis of Non-Alcoholic Steatohepatitis in Rats

Zl, Ai; Zhu, Chengliang; Mu, Min; Wang, J; Ch, Lan; Ll, Fan; Sun, Wei; Df, Chen

doi:10.1177/147323001103900410

Cited by 23 publications

(15 citation statements)

References 51 publications

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“…Moreover, the role of SREBP‐1c in de novo lipogenesis and NAFLD pathogenesis is well acknowledged and has been suggested as a potential therapeutic target . Thus, the LXR‐α/SREBP‐1c signaling may contribute to the development of NAFLD . Our result exhibited that Q3GA dose‐dependently decreased SREBP‐1c and its downstream key gene FAS mRNA expression in in vitro and in vivo NAFLD models.…”

Section: Discussionsupporting

confidence: 51%

Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

Wang

Zhang

Hassan

et al. 2015

Hepatology Research

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Section: Discussionsupporting

confidence: 51%

Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

Wang

Zhang

Hassan

et al. 2015

Hepatology Research

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“…3d), perhaps as a consequence of hepatic lipid metabolism modulation by PTX. The expressions of FASN and SREBP-1c are considered key factors for the progression of NAFLD/NASH (Ai et al, 2011;Blaslov et al, 2014). Our present study showed that PTX treatment reduces hepatic TG content, ameliorates hepatic steatosis, and decreases FASN mRNA and protein levels in the liver ( Fig.…”

Section: Discussionmentioning

confidence: 81%

Pentoxifylline prevents nonalcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis

Shirakami

Shimizu

Kubota

et al. 2016

European Journal of Cancer Prevention

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Nonalcoholic steatohepatitis (NASH) has gained attention as a hepatic manifestation associated with metabolic syndrome and one of the causes for chronic liver damage leading to hepatocellular carcinoma. Although no standard medicinal treatment for NASH has been established, pentoxifylline (PTX), a medicine used to improve circulation, has recently been reported to ameliorate the histopathological appearance of NASH. In the present study, we investigated the effects of PTX on the development of NASH and diethylnitrosamine-induced liver tumorigenesis in C57BLKS/J- +Lepr/+Lepr obese and diabetic mice, which are considered a rodent model for NASH-related hepatocarcinogenesis. Mice were administered diethylnitrosamine, and then they received water with or without PTX. At the time of sacrifice, the development of hepatic pre-neoplastic lesions was significantly suppressed in the PTX groups. Hepatic triglyceride contents were decreased by PTX administration. The serum levels of triglyceride, free fatty acid, and alanine aminotransferase were all decreased by PTX treatment, as was the mRNA expression of proinflammatory cytokines, macrophage-inducing chemokines, and several lipogenic genes in the liver. In-vitro studies also showed that PTX treatment decreased the expression of several lipogenic genes and chemokines in cell lines. These findings suggest that PTX prevents NASH-related liver tumorigenesis by attenuating chronic hepatic inflammation and decreasing lipogenic gene expression in the liver.

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“…Hence, it is believed to be a determinant of the maximal capacity of a tissue (the liver in particular) to synthesize fatty acids by de novo lipogenesis. Increases in FAS levels are attributed to elevation of serum levels of TG and NFEAs as well as liver TG31. Hence, downregulation of FAS expression might lead to a reduction in lipid levels in the liver and serum in Benifuuki-fed mice.…”

Section: Discussionmentioning

confidence: 99%

Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder

Suzuki

Kumazoe

Kim

et al. 2013

Sci Rep

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We investigated the effects of extracts of Benifuuki (a tea cultivar that contains methylated catechins such as epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3”Me)) in mice fed a high-fat/high-sucrose (HF/HS) diet. This tea cultivar was then compared with an extract of Yabukita (a popular tea cultivar that lacks methylated catechins). For 6 weeks, C57BL/6J mice were fed either HF/HS diet with or without tea extracts from tea cultivars, which contained almost identical ingredients except for methylated catechins (i.e., Yabukita (0.2% and 1%) or Benifuuki (0.2% and 1%) extract powders). Supplementation with Benifuuki 0.2% markedly lowered plasma levels of TG and NEFAs compared with mice supplemented with Yabukita 0.2%. The diet containing Benifuuki 1% decreased adipose tissue weights, liver TG, and expression of lipogenic genes in the liver. These results suggested that Benifuuki had much greater lipid-lowering effects than Yabukita. Taken together, these data suggest that methylated catechins direct the strong lipid-lowering activity of Benifuuki.

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The Role of Hepatic Liver X Receptor α-and Sterol Regulatory Element Binding Protein-1c-Mediated Lipid Disorder in the Pathogenesis of Non-Alcoholic Steatohepatitis in Rats

Cited by 23 publications

References 51 publications

Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

Pentoxifylline prevents nonalcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis

Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder

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