The role of high-sensitivity C-reactive protein for assessing coronary artery disease severity and left ventricular end diastolic pressure in patients with suspected coronary artery disease

Rashidinejad, Hamidreza; Rashidinejad, Alireza; Moazenzadeh, Mansoor; Bs, Azimzadeh; Rm, Afshar; Shahesmaeili, Armita; Mirzaeepour, F

doi:10.12809/hkmj133601

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Various studies have indicated hs-CRP as a predictor of cardiovascular events such as myocardial infarction, stroke, peripheral vascular obstruction among apparently healthy men and women as well as the elderly and smokers [ 21 – 23 ]. Rashidinejad and colleagues concluded that high-sensitivity CRP level is a clinical parameter that was not associated with the severity of coronary artery disease [ 24 ]. Several investigations in healthy as well as high-risk individuals have demonstrated a relationship between CRP and the risk of coronary artery disease (CAD) [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Serum Levels of Hs-CRP and Coronary Lesion Severity

Razban

Eslami

Bagherzadeh

2016

Medicine and Pharmacy Reports

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Background and aimIt is very important to know the risk factors of coronary artery disease and the role of inflammatory markers. One of these markers is hs-CRP that has been indicated to increase in patients with coronary artery atherosclerosis. The main objective of this study was to determine the relationship between serum levels of hs-CRP and coronary lesion severity.MethodsIn the current study, we evaluated the role of hs-CRP in coronary artery disease and measured the relationship between serum hs-CRP levels and the severity of coronary lesions in 102 patients who referred to Imam Khomeini Hospital, Iran. The number of involved coronary arteries was measured. The severity of coronary lesions was evaluated by Gensini scoring method and the association between severity of coronary artery lesions and serum hs-CRP levels and other risk factors were examined.ResultsNo significant difference was found between the two groups in terms of gender. Severity of lesions had no significant difference according to Gensini score in women compared with men. Mean Gensini score was significant between the two groups (66.79±48.12 in hs-CRP positive group versus 21.09±26.25 in negative ones, p<0.05). In addition, diabetic patients were significantly more in hs-CRP positive group than negative hs-CRP group (P<0.05). In terms of smoking, there was a significant difference between the two groups. Percentage of patients with hypercholesterolemia was significantly higher in hs-CRP negative group. There was a significant difference in severity of lesions between smokers and non-smokers.ConclusionNo significant correlation was observed between serum levels of hs-CRP and severity and angiographic extent on coronary arteries in our study. Considering the potential risk of coronary inflammatory process as a new variable, it can help discover new cases of coronary lesions and follow-up and control of the selected cases.

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Section: Introductionmentioning

confidence: 99%

The Relationship between Serum Levels of Hs-CRP and Coronary Lesion Severity

Razban

Eslami

Bagherzadeh

2016

Medicine and Pharmacy Reports

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“…C-reactive protein (CRP) is a sensitive, nonspecific marker of inflammation, which is elevated, among other things, as an effect of the activity of several cytokines. High-sensitivity C-reactive protein (hsCRP) measurement is used for cardiovascular risk estimation, mainly a risk of acute coronary events [19,20,25]. CRP concentration depends on many factors, such as gender, age, body mass, smoking, and physical activity [3,17].…”

Section: Introductionmentioning

confidence: 99%

Insufficient physical activity increases cardiovascular risk in women with low birth mass

Czajkowska

Mazurek

Wiśniewski

et al. 2017

Biomedical Human Kinetics

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SummaryStudy aim: The aim of the study was to evaluate the relationship between low birth mass and concentration of high-sensitivity C-reactive protein (hsCRP) as a cardiovascular risk factor in young women with various levels of physical activity. Materials and methods: 102 female students aged 19.7 ± 0.8 (18.6-23.0) were included. The study group was divided according to the declared physical activity: high physical activity (HPA, n = 69) and low physical activity (LPA, n = 33). Anthropometric indices were measured: body mass, height, hip and waist circumference. hsCRP levels were obtained from venous blood samples. Birth body mass (BBM) and birth height were collected from medical documentation. Results: Women with low BBM and LPA had a significantly higher concentration of hsCRP than women with low BBM and HPA, as well as women with normal BBM. Conclusions: Low birth mass together with low physical activity is a strong predictor of raised concentration of hsCRP, which correlates with an increased risk of cardiovascular and metabolic diseases. Regular physical activity in women with low birth mass may prevent an increased hsCRP concentration, and as a result decrease the risk of cardiovascular and metabolic diseases.

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The role of high-sensitivity C-reactive protein for assessing coronary artery disease severity and left ventricular end diastolic pressure in patients with suspected coronary artery disease

Abstract: High-sensitivity C-reactive protein level is a clinical parameter that could predict left ventricular end diastolic pressure and left ventricular dysfunction, but was not associated with the severity of coronary artery disease.

Cited by 2 publications

References 29 publications

The Relationship between Serum Levels of Hs-CRP and Coronary Lesion Severity

The Relationship between Serum Levels of Hs-CRP and Coronary Lesion Severity

Insufficient physical activity increases cardiovascular risk in women with low birth mass

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