The Role of Hippocampal Estradiol Receptor‐<i>α</i> in a Perimenopausal Affective Disorders‐Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Wang, Xun; Huang, Yipeng; Yuan, Shiwen; Tamadon, Amin; Ma, Sunxiang; Feng, Yi

doi:10.1155/2016/4958312

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…Our results showed that OVX caused a decrease in the levels of ERα in the hippocampus, in agreement with a previous report ( Wang et al, 2016 ). Interestingly, the OVX-mediated decrease in ERα level was reversed by the OST treatment.…”

Section: Discussionsupporting

confidence: 94%

Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice

Adu-Nti

Gao

et al. 2021

Front. Pharmacol.

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Loss of endogenous estrogen and dysregulation of the estrogen receptor signaling pathways are associated with an increase in risk for cognitive deficit and depression in women after menopause. Estrogen therapy for menopause increases the risk of breast and ovarian cancers, and stroke. Therefore, it is critical to find an alternate treatment for menopausal women. Osthole (OST), a coumarin, has been reported to have neuroprotective effects. This study examined whether OST improves ovariectomy (OVX)-induced cognitive impairment, and alleviates anxiety- and depression-like behaviors induced by OVX in mice. Adult female C57BL/6J mice were ovariectomized and then treated with OST at a dose of 30 mg/kg for 14 days. At the end of the treatment period, behavioral tests were used to evaluate spatial learning and memory, recognition memory, anxiety- and depression-like behaviors. A cohort of the mice were sacrificed after 14 days of OST treatment and their hippocampi were collected for measurement of the proteins of interest using western blot. OVX-induced alteration in the levels of proteins was accompanied by cognitive deficit, anxiety- and depression-like behaviors. OST treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by OVX, and reversed OVX-induced alterations in the levels of synaptic proteins and ERα, BDNF, TrKB, p-CREB, p-Akt and Rac1 in the hippocampus. Therefore, reversal of OVX-induced decrease in the levels of hippocampal proteins by OST might contribute to the effects of OST on improving cognitive deficit and alleviating anxiety- and depression-like behaviors induced by OVX.

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Section: Discussionsupporting

confidence: 94%

Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice

Adu-Nti

Gao

et al. 2021

Front. Pharmacol.

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“…Recently, various studies reported the role of ERs in psychiatric disorders including major depression and anxiety. [ 39,40 ] Wang et al explored the role of hippocampal ERα in perimenopausal depressive rats, [ 41 ] and Furata et al reported that E2 attenuated postpartum‐induced anxiety in female rats via ERα. [ 42 ] Conversely, other researchers described ERβ as an important modulator in menopausal depression induced by ovariectomized and 4‐vinylcyclohexen diepoxide (VCD).…”

Section: Discussionmentioning

confidence: 99%

γ‐Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression

Kim,

Yoon,

Cho

et al. 2023

Molecular Nutrition Food Res

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ScopeDepression is a severe mental condition, common among menopausal women. γ‐Oryzanol (ORY) has various biological properties; however, the effect of ORY on menopausal depression and its underlying mechanisms have not been investigated.Methods and resultsORY is orally administered to ovariectomized (OVX) mice for 20 weeks. ORY administration results in lower immobility time in the tail suspension and forced swim test and increases locomotor activity in the open field test. In the primary hippocampal neurons and hippocampi of OVX mice, ORY treatment increases nitric oxide (NO) production and neuronal NO synthase (nNOS) expression. Further, the phosphorylation of extracellular signal‐regulated kinase (ERK), cAMP response element‐binding protein (CREB), and tropomyosin receptor kinase B, along with the expression of brain‐derived neurotrophic factior (BDNF), is upregulated. These stimulatory effects of ORY are diminished by treatment with estrogen receptor β (ERβ) antagonist. ORY similarly interacts with ERβ in the molecular docking analysis. Moreover, intracerebroventricular injection of 7‐nitroindazole, a nNOS inhibitor, abolishes the antidepressant effects of ORY.ConclusionsThe results indicate that ORY attenuates depressive behavior in OVX mice by upregulating ERβ‐mediated hippocampal nNOS expression and activating the ERK‐CREB‐BDNF signaling networks. The findings suggest that ORY is a potential therapeutic agent for attenuating menopausal depression.

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“…In addition, these studies have shown that hippocampus ischemic tolerance is associated with GluR2 elevating after electroacupuncture pretreatment ( Liu et al, 2015 ). And some studies have shown that electroacupuncture pretreatment for hippocampus-related diseases resulted in convalescence ( He X. L. et al, 2016 ; Wang et al, 2016 ; Liu et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats

Shi

Dai

et al. 2021

Front. Aging Neurosci.

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A previous study has demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia. In the present study, we investigated whether adenosine receptor 1 (A1 R) is involved in EA pretreatment-induced cognitive impairment after focal cerebral ischemia in rats. Two hours after EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120 min in male Sprague-Dawley rats. The neurobehavioral score, cognitive function [as determined by the Morris water maze (MWM) test], neuronal number, and the Bax/Bcl-2 ratio was evaluated at 24 h after reperfusion in the presence or absence of CCPA (a selective A1 receptor agonist), DPCPX (a selective A1 receptor antagonist) into left lateral ventricle, or A1 short interfering RNA into the hippocampus area. The expression of the A1 receptor in the hippocampus was also investigated. The result showed that EA pretreatment upregulated the neuronal expression of the A1 receptor in the rat hippocampus at 90 min. And EA pretreatment reversed cognitive impairment, improved neurological outcome, and inhibited apoptosis at 24 h after reperfusion. Pretreatment with CCPA could imitate the beneficial effects of EA pretreatment. But the EA pretreatment effects were abolished by DPCPX. Furthermore, A1 receptor protein was reduced by A1 short interfering RNA which attenuated EA pretreatment-induced cognitive impairment.

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The Role of Hippocampal Estradiol Receptor‐α in a Perimenopausal Affective Disorders‐Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Cited by 5 publications

References 51 publications

Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice

Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice

γ‐Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression

Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats

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