The role of histamine in the acute inflammatory responses to intradermal platelet activating factor.

Sciberras, DG; Jordan, S.; Gill, D.S.; Baber, N.; James, Ian

doi:10.1111/j.1365-2125.1991.tb05617.x

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…But it could be that terfenadine influences the restoration of tissue stores discharged by histamine. Sciberras et al [16] showed that two consecutive daily injections of compound 48/80 depleted skin sites of histamine such that the response to PAF, which discharged histamine from the dermis, was restored only very slowly being complete after a 2 week interval. It could be that histamine injection also discharges tissue histamine, but that the restoration of tissue mechanisms is impeded by terfenadine.…”

Section: Discussionmentioning

confidence: 99%

Actions of terfenadine and cimetidine on histamine wheal formation.

Vere

1995

Brit J Clinical Pharma

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1. A Latin square design was used to compare the effects of four masked oral drugs, placebo, cimetidine, terfenadine and cimetidine plus terfenadine, at single standard doses against histamine injected at concentrations of 0.3 mM and 0.074 mM subepidermally in eight healthy volunteers studied at weekly intervals. 2. Wheal growth occurred in three phases, an initial delay, a phase of rapid growth where drugs were effective, and a phase of slow growth where there were no significant drug effects. 3. Terfenadine was an effective antihistamine. 4. The data were consistent with a terfenadine effect continued into the next treatment block. 5. Under these conditions cimetidine apparently reduced the effects of terfenadine during the rapid wheal growth phase both simultaneously and after a week's interval from terfenadine dosing.

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Section: Discussionmentioning

confidence: 99%

Actions of terfenadine and cimetidine on histamine wheal formation.

Vere

1995

Brit J Clinical Pharma

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“…Also, histamine promotes vasodilatation by inducing the nitric oxide release. It helps in maintaining the acutephase response during inflammation (45,47). Histamine is shown to induce the proliferation of several cancer cells including BC (48)(49)(50).…”

Section: Vasoactive Aminesmentioning

confidence: 99%

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Deshmukh¹,

Srivastava²,

Poosarla³

et al. 2019

Ann. Transl. Med.

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Breast cancer is the most commonly diagnosed malignancy and a leading cause of cancerrelated death in women worldwide. It also exhibits pronounced racial disparities in terms of incidence and clinical outcomes. There has been a growing interest in research community to better understand the role of the microenvironment in cancer. Several lines of evidence have highlighted the significance of chronic inflammation at the local and/or systemic level in breast tumor pathobiology. Inflammation can influence breast cancer progression, metastasis and therapeutic outcome by establishing a tumor supportive immune microenvironment. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Targeting of immune and inflammatory pathways has met tremendous success in some cancers underscoring the importance of research to further our understanding of these systems in breast cancer. This knowledge can be helpful not only in the development of novel prevention and therapeutic strategies, but also help in better prediction of therapeutic responses in patients. This review summarizes some of the significant findings on the role of inflammation in breast cancer to gain collective molecular and mechanistic insights. We also discuss ongoing efforts and future outlook to exploit the existing knowledge for improved breast cancer management.

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