The Role of Histamine in Ocular Allergy

Ohbayashi, Masaharu; Manzouri, Bita; Morohoshi, Kei; Fukuda, Ken; Ono, Santa Jeremy

doi:10.1007/978-1-4419-8056-4_5

Cited by 14 publications

(11 citation statements)

References 37 publications

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“… 31 , 35 H4 receptors mediate the recruitment of mast cells, eosinophils, and T-lymphocytes to the site of allergen-induced inflammation. 35 , 38 This further amplifies the histamine-mediated immunopathological response in the conjunctiva. 33 In ocular allergy, histamine binding to H4 receptors on eosinophils primes eosinophils to respond to eotaxin, a chemokine for eosinophils.…”

Section: Histaminementioning

confidence: 97%

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

Chigbu¹,

Coyne²

2015

OPTH

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Allergic disorders of the ocular surface are primarily characterized as IgE- and/or T-lymphocyte-mediated disorders that affect the cornea, conjunctiva, and eyelid. Approximately 40% of individuals in the developed countries have allergic conjunctivitis, and as such, it is the most common form of ocular allergy. Seasonal allergic conjunctivitis is the most prevalent type of allergic conjunctivitis that impacts the quality of life of patients. This article reviews the pharmacology, pharmacodynamics, pharmacokinetics, clinical trials, clinical efficacy, and safety of alcaftadine. Histamine and the pathological mechanism of ocular allergy will be briefly reviewed with the intent of providing a background for the detailed discussion on the clinical utility of alcaftadine in allergic conjunctivitis. The Medline PubMed, Elsevier Science Direct, and Google Scholar databases were used to search for evidence-based literature on histamine and immunopathological mechanism of allergic conjunctivitis, as well as on pharmacology, pharmacodynamics, pharmacokinetics, clinical trials, and clinical efficacy of alcaftadine. The treatment and management goals of allergic conjunctivitis are to prevent or minimize the inflammatory cascade associated with allergic response in the early stages of the pathological mechanism. It is of note that activation of histamine receptors on immune and nonimmune cells are associated with allergen-induced inflammation of the conjunctiva and its associated ocular allergic manifestations, including itching, edema, hyperemia, and tearing. Alcaftadine is an efficacious multiple action antiallergic therapeutic agent with inverse agonist activity on H1, H2, and H4 receptors, as well as anti-inflammatory and mast cell stabilizing effects that could provide therapeutic benefits to patients with allergic conjunctivitis.

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Section: Histaminementioning

confidence: 97%

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

Chigbu¹,

Coyne²

2015

OPTH

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“…Among them, IL-3 and IL-5 are involved in the development, survival, and recruitment of eosinophils, which are helpful for the occurrence of eosinophilic inflammation. Histamine is the main agent involved in ocular anaphylaxis [41]. Among the known histamine receptors, H1R, H2R, and H4R subtypes are closely related to eye allergies.…”

Section: Classical Biological Mechanismsmentioning

confidence: 99%

“…Among the known histamine receptors, H1R, H2R, and H4R subtypes are closely related to eye allergies. Histamine signals have been shown to increase conjunctival hyperemia, fibroblast proliferation, cytokine secretion, expression of adhesion molecules, microvascular permeability, and procollagen production through H1R and H2R [41]. H4R regulates a variety of physiological functions, including the release of cytokines and chemokines, expression of adhesion molecules and chemotaxis, and recruitment of mast cells, eosinophils, dendritic cells, and lymphocytes into the conjunctiva [42,43].…”

Section: Classical Biological Mechanismsmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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“…In the short term, their strong efficacy involves the risk of self‐medication and in the long‐term steroid dependence with the concomitant risk of iatrogenic complications such as cataract and cortisone glaucoma. Topical non‐steroidal anti‐inflammatory drugs are rarely used because they are not always well tolerated . Systemic anti‐inflammatory drugs are only exceptionally used to overcome a difficult period in selected cases of severe forms.…”

Section: Treatmentmentioning

confidence: 99%

Diagnosing and managing allergic conjunctivitis in childhood: The allergist’s perspective

Fauquert

2019

Pediatric Allergy Immunology

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Allergic conjunctivitis in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. An ophthalmologist should be consulted when conjunctivitis occurs alone and if another form of conjunctivitis is suspected, such as perennial allergic conjunctivitis, vernal keratoconjunctivitis or atopic keratoconjunctivitis. When IgE‐mediated hypersensitivity assessment does not establish aetiological diagnosis, a conjunctival allergen provocation test can be performed. The principal non‐IgE‐mediated allergy is chronic blepharoconjunctivitis. The main problem for differential diagnosis is the presence of signs suggestive of dry eye. Management includes non‐pharmacological treatments, such as lacrimal substitutes, avoidance measures and protection of the ocular surface. Second‐line treatment consists of eye drops, preferably single dose or without additives and with dual local action, mast cell stabilizer action and antihistaminic action. Third‐line treatment is reserved for severe forms. Short‐lasting local steroid therapy can control flare‐ups of allergic keratoconjunctivitis, which should have specialized follow‐up. Cyclosporine is a disease‐modifying treatment, which is both effective and well tolerated.

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The Role of Histamine in Ocular Allergy

Cited by 14 publications

References 37 publications

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Diagnosing and managing allergic conjunctivitis in childhood: The allergist’s perspective

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The Role of Histamine in Ocular Allergy

Cited by 14 publications

References 37 publications

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of&nbsp;allergic conjunctivitis

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of&nbsp;allergic conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Diagnosing and managing allergic conjunctivitis in childhood: The allergist’s perspective

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Product

Resources

About

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis