2024
DOI: 10.3390/microorganisms12030425
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The Role of HIV-1-Encoded microRNAs in Viral Replication

Ofira Carmi,
Yosef Gotlieb,
Yonat Shemer-Avni
et al.

Abstract: microRNAs (miRNAs) are small non-coding RNAs (sncRNAs) that play an important role in the life cycle of human viruses. We sought to characterize human immunodeficiency virus 1 (HIV-1)-encoded miRNAs and determine their role in viral replication. Initially, a bioinformatic analysis was used to predict HIV-1-encoded miRNAs. Next, a representative number of these predicted sequences were verified using a miRNA microarray chip, reverse transcription PCR (RT-PCR), and the deep sequencing of RNA extracted from HIV-1… Show more

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“…This could be due to the fact that viral miRNAs are more recently discovered and the current databases for their recognition by NGS data have difficulty being updated promptly. For example, the database used in the present study could not detect some recently discovered HIV-encoded miRNAs described in [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…This could be due to the fact that viral miRNAs are more recently discovered and the current databases for their recognition by NGS data have difficulty being updated promptly. For example, the database used in the present study could not detect some recently discovered HIV-encoded miRNAs described in [ 42 ].…”
Section: Discussionmentioning
confidence: 99%