The Role of HMGB1and KIM-1 Repair Genes in the Progression of Kidney Failure Disease

Abstract

Renal Failure(RF) is a leading clinical characteristic of patients in nephrology , it represents significant concern and the main challenge for healthcare systems. The incidence rate of RF is rising globally , mainly as a result of increased aging population. The current study , was performed to identify the effect of HMGB1and KIM-1gene expression in renal failure disease focusing on it is role on the repair processes. This study comprises 100 patients diagnosed clinicaly and seriologicaly with renal failure )52 males and 48 females ) their age vary from (17 to 80 years) and 30 healthy individuals as a control group( 18 males and 12 females ). RNA extracted from blood samples and converted to cDNA which subjected to real-time PCR for detection gene expression .HMGB1 and KIM-1 have significantly overexpression (3.51 folds and 5.37 folds ) respectively in RF patients compared with healthy control subjects ( p <0.05). However , HMGB1 and KIM-1 gene folding elevated gradually with advance the severity of the RF disease.