The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached, Nessr Abu; Gambichler, Thilo; Dietrich, Johannes W.; Ocker, Lennart; Seifert, Caroline; Stockfleth, Eggert; Bechara, Falk G.

doi:10.3390/ijms232315250

Cited by 38 publications

(29 citation statements)

References 85 publications

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“…Thus, on the one hand, further prospective studies are needed to determine whether anti-inflammatory therapy in HS patients influences insulin sensitivity and disease severity. On the other hand, many case series and reports show improvement in HS disease severity in patients on antidiabetic medication [ 5 , 10 ]. This further suggests that the disease severity of DM and HS may be, at least partially, linked through common mechanisms and negatively impact each other, presumably by promoting chronic inflammation in a vicious, proinflammatory circle.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, our results highlight the importance of adipose tissue as an endocrine organ in the evolution of HS. Some studies in HS showed a disbalance of adipokines compared to the control subjects, independently of BMI [ 5 ]. We propose that adipose tissue in HS should be further investigated regarding its function and structure.…”

Section: Discussionmentioning

confidence: 99%

“…Current therapy for HS includes a variety of local therapies, antiseptic measures, antibiotics, biologics, surgery, and new-small molecule drugs [ 3 , 4 ]. HS is also associated with endocrine abnormalities and comorbidities [ 5 ]. Among these, diabetes mellitus (DM) may be the most common endocrine comorbidity in HS patients.…”

Section: Introductionmentioning

confidence: 99%

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Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany

Rached

Gambichler

Ocker

et al. 2023

IJMS

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Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was to identify high-risk groups of HS patients that develop DM and to assess the frequency of different types of DM present in HS patients. To do so, we conducted a monocentric study in 99 patients with HS. All patients underwent detailed clinical and laboratory assessments, including the determination of glycated hemoglobin. Among the 20.2% of patients that presented with DM, type 2 was by far the most prevalent (19 out of 20 patients). Moreover, male gender, age, BMI, Hurley stage, modified Hidradenitis Suppurativa Score (mHSS), DLQI and hypertension all correlated with the glycated hemoglobin levels in the HS patients. In the multivariable analysis, Hurley stage III, older age, and higher BMI were significantly associated with DM. Specifically, patients at Hurley stage III were at a 5.3-fold increased risk of having DM type II compared to patients at earlier Hurley stages. Since many of the HS patients had not been diagnosed, our study reveals shortcomings in the screening for DM and suggest that this should be routinely performed in HS patients at high risk to avoid secondary complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany

Rached

Gambichler

Ocker

et al. 2023

IJMS

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“…The most common comorbidities in our HS collective were obesity (59.5%), hypertension (29.8%) and diabetes mellitus (19.8%). Indeed, it is well‐established that a disproportionately high number of HS patients suffer from obesity, metabolic syndrome, and insulin resistance 2,3,24 . Future studies into Hp‐phenotyping might provide a mechanistic link between the prevalence of these metabolic alterations and HS pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study

Abu Rached,

Gambichler,

Ocker

et al. 2023

Acad Dermatol Venereol

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BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory disease that is highly correlated with obesity. Haptoglobin serum levels have recently been recognized as an important biomarker linking obesity with chronic inflammation.ObjectiveTo compare haptoglobin with previously proposed serum biomarkers for the determination of disease severity in HS patients. For this purpose, disease severity of HS patients was determined by a panel of clinical scores as well as several risk factors, such as weight and smoking habits.MethodsA prospective, diagnostic accuracy study was performed at the International Centre for Hidradenitis suppurativa/Acne inversa Bochum (ICH). The study included a total of 263 patients, including 131 who had a confirmed diagnosis of HS in Hurley I (n=16), II (n=56), and III (n=59) HS, and 132 healthy controls. The main outcome was to identify serological inflammatory markers for HS disease severity [severe (III) vs. moderate/mild (II/I)] as assessed by Hurley classification.ResultsThe serum levels of acute phase proteins haptoglobin and CRP, as well as the number of neutrophils in peripheral blood, number of monocytes, the systemic immune‐inflammation index and the pan‐immune‐inflammatory value correlated with disease severity according to established clinical scores (mHSS, SAHS, Hurley, DLQI). HS patients had significantly higher haptologlobin levels compared to healthy controls. Logistic regression analysis revealed haptoglobin as the only independent marker predicting severe HS.ConclusionIn this prospective study, we discovered that the serum levels of the acute phase protein haptoglobin levels serve as an independent marker of disease severity in HS. While this presents the first study in the context of HS. Thus, the present data not only yield a highly promising serum marker to be further validated.

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“…Aggravating, burdensome pain and itching as well as a malodourous discharge are the leading symptoms among patients with HS [3][4][5]. Up until now, the topic of the etiopathogenesis of this disease is being studied, although research on the main origin leans towards an autoinflammatory and genetic as well as a suspected hormonal background [6][7][8]. Additionally, HS patients usually present with other comorbidities such as, obesity and metabolic syndrome [9,10].…”

Section: Introductionmentioning

confidence: 99%

Satisfaction with Life and Coping Strategies among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study

Rymaszewska

Krajewski

Matusiak

et al. 2023

JCM

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Introduction: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory dermatosis with vast psychosocial burden. The objective of this study is to thoroughly analyze satisfaction with life (SWL) and coping strategies of HS patients in relation to the clinical and psychosocial factors. Methods: 114 HS patients (53.1% females; mean age 36.6 ± 13.1 years) were enrolled. Severity of the disease was measured using Hurley staging and International HS Score System (IHS4). Instruments utilized: Satisfaction with Life Scale (SWLS); Coping-Orientation to Problems-Experienced Inventory (Brief COPE); HS Quality of Life Scale (HiSQoL); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); General Health Questionnaire (GHQ-28). Results: SWL was low in 31.6% of HS patients. No relation was found between SWL and Hurley staging and IHS4. SWL correlated with GHQ-28 (r = −0.579 p < 0.001), PHQ-9 (r = −0.603 p < 0.001), GAD-7 (r = −0.579 p < 0.001), and HiSQoL (r = −0.449 p < 0.001). Problem-focused coping strategies were most commonly used, followed by emotion-focused coping and avoiding coping strategies. Significant differences were found between the following coping strategies and SWL: self-distraction (p = 0.013), behavioral-disengagement (p = 0.001), denial (p = 0.003), venting (p = 0.019), and self-blame (p = 0.001). Conclusions: HS patients present low SWL which correlates with psychosocial burden. Reducing anxiety–depression comorbidity and encouraging optimal coping strategies may be of great importance in holistic approach to HS patients.

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The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Cited by 38 publications

References 85 publications

Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany

Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa—A Monocentric Study in Germany

Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study

Satisfaction with Life and Coping Strategies among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study

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