The role of hormones in the pathogenesis of psoriasis vulgaris

Roman, Iulia Ioana; Constantin, Anne-Marie; Marina, Mihaela; Orăsan, Remus Ioan

doi:10.15386/cjmed-505

Cited by 22 publications

(27 citation statements)

References 109 publications

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“…In the present study, the high frequency of psoriasis attack was among males rather than females, this may be due to the hormonal differences between them [25,26], and in turn, their effect on immune response [27], consequently males tend to provoke more T-helper cells which have a proinflammatory role in inducing or development of psoriasis to become severe incidence [28].…”

Section: Resultsmentioning

confidence: 53%

“…The results clarified that the age was ranged between 20-60 years and the mean age for psoriasis was 42.8±2.0. The results recorded that most psoriasis patients (52.08 %) were within the second and third decades (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) year, while the lowest percentages were in (51-65) year. This results were in agreement with [19,20], who indicated that the age of psoriatic patients was within the second and third decades.…”

Section: Resultsmentioning

confidence: 98%

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Effect of the Biological Drug Etanercept on Tumor necrosis factor-α Levels in Psoriatic Patients

Kuba

Al-Qadhi

Fadheel

2018

ijs

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Psoriasis is a common, chronic, immune mediated disorder.The disease is arising as a result of dysregulated interactions of the innate and adaptive immune system in the context of skin epithelium and connective tissue. The biological drug Etanercept(ETN) approved for use in treated psoriasis. ETN is tumor necrosis factor-α (TNF-α) inhibitor. In this study, 48 psoriatic patients were taken before and after treatment who attended to the Dermatology and Venereology Department in Baghdad Teaching Hospital during the period from December 2016 to September 2017and 50 samples were used as healthy control group. The results showed that most psoriatic patients 52.08 % were within the second and third decades 20-35 year, and the majority of psoriatic patients were males 62.5% and the ratio of male to female is 1.67:1. Moreover, the results demonstrated that the males were more expected psoriasis compare with females. Blood samples were collected and TNF-α was estimated in sera of all subjects by using Enzyme Linked Immunosorbent Assay (ELISA). The TNF-α mean levels in psoriatic patients before treatment was 189.5±26.0 ng/ml, and after treatment was 223.6±41.1 ng/ml compar with the healthy control group 93.5±2.4 ng/ml. The results showed significant differences between the studied groups.

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Section: Resultsmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 98%

Effect of the Biological Drug Etanercept on Tumor necrosis factor-α Levels in Psoriatic Patients

Kuba

Al-Qadhi

Fadheel

2018

ijs

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“…It is well known that the nervous system, the endocrine system and the skin have the same embryological origin, from the ectoderm [86]. Also, the function and the normal development of the skin are influenced by hormones, among them sex hormones, thyroid hormones or stress hormones [87].…”

Section: Endocrine Assessment In Psoriasismentioning

confidence: 99%

Evaluation of Psoriasis Patients

Orăsan¹,

Roman²,

Coneac³

2019

Tailored Treatments in Psoriatic Patients

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Psoriasis represents a chronic inflammatory skin disease with multisystemic involvement. The development of this autoimmune disorder depends on a complex interplay of genetic and environmental factors. Besides presenting the conditions associated with psoriasis, the chapter outlines the role of hormones (sex hormones, prolactin, and thyroid hormones) in psoriasis pathogenesis and evolution. The chapter indicates the clinical approaches recommended in practice: a detailed medical history collection (including prior exposure to treatments and evaluation of co-medication), a thorough physical examination (with the completion of specific severity and QoL scales), laboratory investigations and screening for malignancies (including lymphoma and skin cancer) or infection (Tuberculosis, Crohn's disease). European Guidelines encourage the dermatologist to check for hypersensitivity, metabolic, gastro-intestinal and renal disorders, check for the need of vaccines and contraception. We discuss pre-treatment, during-treatment and post-treatment evaluation options and underline the necessity of clear evaluation steps in the assessment of psoriasis patients.

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“…For example, the thyroid hormones, triiodothyronine (T3) and free thyroxine (T4) cause an increase in the Epidermal Growth Factor (EGF) which leads to epidermal hyperplasia, also determining the proliferation of keratinocytes (3), an aspect commonly found in psoriasis vulgaris. On the other hand, sexual hormones, such as estrogens, modulate the immune responses: either by decreasing the psoriatic inflammation or by stimulating the proliferation at keratinocyte level (4). Prolactin (PRL), a pituitary hormone involved in lactation and reproduction has also been mentioned as an important immune modulator (5).…”

Section: Introductionmentioning

confidence: 99%