The Role of Host Genetic Variation in HIV Infection and its Manifestations

Kaslow, Richard A.; Tang, James; Dorak, M. Tevfik

doi:10.1016/b978-012764051-8/50014-7

Cited by 2 publications

(2 citation statements)

References 212 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Effects of host genetic diversity on susceptibility or resistance to HIV-1 infection have been documented for several HLA loci [6,[28][29][30][31], but reported relationships have been less consistent for class II than for class I markers [32]. The apparent protection against heterosexual HIV-1 infection by DRB1*1301 (or DRB1*1301-DQB1*0501) and DRB1*1302-DQB1*0604 here bears some similarity to the earlier observation of resistance to vertical transmission of HIV-1 in black and Hispanic infants with the DRB1*13 allele [29].…”

Section: Discussionmentioning

confidence: 96%

HLA‐DRB1and‐DQB1Alleles and Haplotypes in Zambian Couples and Their Associations with Heterosexual Transmission of HIV Type 1

et al. 2004

View full text Add to dashboard Cite

In 292 initially human immunodeficiency virus (HIV)-1-serodiscordant and cohabiting Zambian couples, HLA-DRB1 and -DQB1 variants were associated with HIV-1 transmission events during a 7-year follow-up period. Initially seronegative partners with either DRB1*0301-DQB1*0201 (relative hazard [RH], 1.60; P=.009) or DRB1*1503-DQB1*0602 (RH, 1.67; P=.03) showed accelerated seroconversion. Carriage of DRB1*1301 in initially seropositive partners led to delayed transmission of HIV to their spouses (RH, 0.54; P=.05). The combined groups of seroprevalent and seroincident partners (n=433) also differed from those who remained seronegative (n=151), with regard to 2 common haplotypes, DRB1*1302-DQB1*0604 (relative odds [RO], 0.28; P=.003) and DRB1*1503-DQB1*0602 (RO, 1.81; P=.02). Statistical adjustments for other host factors (age, sex, genital ulcer, and index partner's virus load) known to influence transmission of HIV-1 seldom altered the genetic relationships. Overall, associations of HLA class II polymorphisms with both HIV transmission and acquisition are not as readily interpretable as are effects reported for other loci.

show abstract

Section: Discussionmentioning

confidence: 96%

HLA‐DRB1and‐DQB1Alleles and Haplotypes in Zambian Couples and Their Associations with Heterosexual Transmission of HIV Type 1

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Immunogenetic studies of human infectious diseases, including HIV-1 infection, hepatitis B and C, and tuberculosis, have revealed that many variants across different HLA specificities may account for resistance or susceptibility to infection and/or disease progression [8,9]. Host genetic correlates for C. trachomatis infection in humans have begun to emerge from analyses of HLA polymorphisms, primarily in patients with Chlamydia-associated tubal factor infertility, pelvic inflammatory disease, trachoma, and chlamydial hsp60 syndromes [10][11][12][13][14][15].…”

mentioning

confidence: 99%

Epidemiological and Genetic Correlates of IncidentChlamydia trachomatisInfection in North American Adolescents

et al. 2004

View full text Add to dashboard Cite

Epidemiological and genetic correlates of Chlamydia trachomatis infection were examined prospectively in 124 male and 361 female adolescents at high risk for human immunodeficiency virus type 1 (HIV-1) infection. Seventy percent of subjects were African American, and 68% had HIV-1 infection. As expected, younger age (<17 years), multiple sex partners (> or =2), and prior chlamydial infection predicted chlamydial infection during a 6-56-month follow-up period (P=.02, P=.02, and P=.03, respectively). Human leukocyte antigen (HLA) class II variant DQB1*06 (mostly *0602 and *0603) was associated with chlamydial infection (49% vs. 34%; adjusted relative odds [RO], 1.8; P=.005), as was HLA class I haplotype B*44-Cw*04 (10% vs. 4%; RO, 3.2; P=.009). DQB1*06 was found in 9 (75%) of 12 female adolescents with chlamydial pelvic inflammatory disease. In contrast, sex, ethnicity, and HIV-1 infection did not predict chlamydial infection. These findings suggest that antigen presentation in adaptive immune responses may serve as a major factor in effective control of C. trachomatis infection. The underlying mechanisms remain to be experimentally elucidated.

show abstract

The Role of Host Genetic Variation in HIV Infection and its Manifestations

Cited by 2 publications

References 212 publications

HLA‐DRB1and‐DQB1Alleles and Haplotypes in Zambian Couples and Their Associations with Heterosexual Transmission of HIV Type 1

HLA‐DRB1and‐DQB1Alleles and Haplotypes in Zambian Couples and Their Associations with Heterosexual Transmission of HIV Type 1

Epidemiological and Genetic Correlates of IncidentChlamydia trachomatisInfection in North American Adolescents

Contact Info

Product

Resources

About