The Role of Hoxb13 in Biological Medicine - A General Overview

Abstract

In the development of epithelial prostate gland, the homeobox protein (HOXB13) plays a crucial role. The prostate gland pathogenesis is thought to be aided by the overexpression of HOXB13, which is observed throughout the development of prostatic tissue's malignant transformation. The tumor suppressor protein p21 is hypothesized to be inhibited by HOXB13 in androgen-decient circumstances. To have a deeper knowledge of HOXB13's function in prostate cancer, its crucial cascade partners in the ventral prostate development must be claried. In this review, we discuss the different roles of HOXB13 in other malignancies along with the prostate cancer including its functions such as wound healing, cellular differentiation, and angiogenesis