The role of HPV gene expression and selected cellular MiRNAs in lung cancer development

Hussen, Bashdar Mahmud; Ahmadi, Gelavizh; Marzban, Havva; Azar, Maryam Ebadi Fard; Sorayyayi, Saba; Karampour, Romina; Nahand, Javid Sadri; Hidayat, Hazha Jamal; Moghoofei, Mohsen

doi:10.1016/j.micpath.2020.104692

Cited by 46 publications

(22 citation statements)

References 77 publications

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“…Although not all the cases presented with expression alterations in these genes, these results were recently corroborated by Furuya et al, who also described TP53 reduced expression levels in penile tumors. Compared to other cancers (Santos et al, 2018;Datta et al, 2019;Hussen et al, 2021;Liu et al, 2021), few studies have described epigenetic events in penile tumors, whether evaluating miRNAs (Zhang et al, 2015;Hartz et al, 2016;Kuasne et al, 2017;Peta et al, 2017;Ayoubian et al, 2021;Furuya et al, 2021) or by evaluating methylation patterns (Feber et al, 2015;Kuasne et al, 2015;Marchi et al, 2017). Changes by both mechanisms could justify the downregulation of TP53 and RB1, however only RB1 has been reported to be hypermethylated (Marchi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

et al. 2022

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Cancer development by the human papillomavirus (HPV) infection can occur through the canonical HPV/p53/RB1 pathway mediated by the E2/E6/E7 viral oncoproteins. During the transformation process, HPV inserts its genetic material into host Integration Sites (IS), affecting coding genes and miRNAs. In penile cancer (PeCa) there is limited data on the miRNAs that regulate mRNA targets associated with HPV, such as the TP53 and RB1 genes. Considering the high frequency of HPV infection in PeCa patients in Northeast Brazil, global miRNA expression profiling was performed in high-risk HPV-associated PeCa that presented with TP53 and RB1 mRNA downregulated expression. The miRNA expression profile of 22 PeCa tissue samples and five non-tumor penile tissues showed 507 differentially expressed miRNAs: 494 downregulated and 13 upregulated (let-7a-5p, miR-130a-3p, miR-142-3p, miR-15b-5p miR-16-5p, miR-200c-3p, miR-205-5p, miR-21-5p, miR-223-3p, miR-22-3p, miR-25-3p, miR-31-5p and miR-93-5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. One hundred and thirty-one and 490 miRNA binding sites were observed for TP53 and RB1, respectively, most of which were in seedless regions. These findings suggest that up-regulation of miRNA expression can directly repress TP53 and RB1 expression by their binding sites in the non-canonical seedless regions.

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Section: Discussionmentioning

confidence: 99%

Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

et al. 2022

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“…In Tehran-Iran, Rezaei et al (2020) found HPV in 54 out of 102 (52.9%) lung cancers by using PCR for the L1 and E7 genes and by genotyping by INNO-LiPA [ 122 ]. In Iran, Hussen et al reported an HPV presence in 61 out of 109 (56%) lung cancer tissues by using PCR and RLB [ 123 ]. In China, Wu et al (2021) detected the presence of HPV DNA in 16 out of 100 (16%) patients with NSCLC by using RT-qPCR [ 124 ].…”

Section: Epidemiology Of Hpv In Lung Cancermentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Osorio

Candia-Escobar

Corvalán

et al. 2022

Biology

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Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.

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“…Recent studies have shown that miRNAs are involved in the pathophysiological processes of various diseases, such as cardiovascular diseases, tumorigenesis and neurological diseases, and have been found to be closely associated with the growth and development of lung diseases such as lung tumours, pulmonary fibrosis and pneumonia, as well as their development and regression 10,11 . miR‐23a‐3p was highly expressed in ovarian cancer, lung cancer, gastric cancer and promoted cancer cell proliferation, migration and invasion 12–14 . miR‐23a‐3p has also been shown to play an important role in the intrinsic immune and inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 miR-23a-3p was highly expressed in ovarian cancer, lung cancer, gastric cancer and promoted cancer cell proliferation, migration and invasion. [12][13][14] miR-23a-3p has also been shown to play an important role in the intrinsic immune and inflammatory response. Loss of miR-23a-3p in T cells resulted in elevated T FH cell frequencies upon different immune challenge hereas overexpression of miR-23a-3p led to reduced TFH cell responses.…”

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confidence: 99%

MicroRNA‐23a‐3p promotes macrophage M1 polarization and aggravates lipopolysaccharide‐induced acute lung injury by regulating PLK1/STAT1/STAT3 signalling

Jiang

Sun

Zhu

et al. 2022

Int J Experimental Path

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Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are severe respiratory syndromes, which cause high morbidity and mortality. Various pathological factors have been inplicated in pathogenesis. 1 These include increased alveolar capillary permeability and persistent excessive inflammation, which lead to pulmonary oedema, hypoxemia, cell apoptosis and destruction of lung structure. 2,3 Although the types of available clinical therapy for ALI have increased during the past few decades, the overall survival rate has not improved as much as might be expected. Therefore research into the molecular pathogenesis is still necessary and will provide -hopefully -new ideas and targets for the treatment of ALI.Macrophages are the most important regulators of the local inflammatory micro-environment and hence of the overall inflammatory response in the lung, mainly including alveolar macrophage (AM), pulmonary mesenchymal macrophage and bronchial macrophage, of which AM accounted for >90%. 4,5 AM plays a key role in maintaining

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The role of HPV gene expression and selected cellular MiRNAs in lung cancer development

Cited by 46 publications

References 77 publications

Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

MicroRNA‐23a‐3p promotes macrophage M1 polarization and aggravates lipopolysaccharide‐induced acute lung injury by regulating PLK1/STAT1/STAT3 signalling

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