The Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract

Pawełczyk, Małgorzata; Kowalski, Marek L.

doi:10.1007/s11882-017-0685-2

Cited by 64 publications

(54 citation statements)

References 64 publications

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“…Reduction in community-wide ILI burden might reduce morbid events and hospitalizations, especially for patients at risk for cardiopulmonary events such as acute myocardial infarction or exacerbations of chronic obstructive pulmonary disease or asthma. 7,[46][47][48] These findings have potential implications for epidemiologic and health services studies designed to evaluate clinical outcomes over time. The variability in timing and severity of each influenza season (and resulting ILI incidence) can affect morbidity and mortality events, and investigators should consider accounting for ILI in their analyses.…”

Section: Discussionmentioning

confidence: 93%

Excess Deaths Attributable to Influenza-Like Illness in the ESRD Population

Gilbertson

Rothman

Chertow

et al. 2019

JASN

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Background Morbidity and mortality vary seasonally. Timing and severity of influenza seasons contribute to those patterns, especially among vulnerable populations such as patients with ESRD. However, the extent to which influenza-like illness (ILI), a syndrome comprising a range of potentially serious respiratory tract infections, contributes to mortality in patients with ESRD has not been quantified.Methods We used data from the Centers for Disease Control and Prevention (CDC) Outpatient Influenzalike Illness Surveillance Network and Centers for Medicare and Medicaid Services ESRD death data from 2000 to 2013. After addressing the increasing trend in deaths due to the growing prevalent ESRD population, we calculated quarterly relative mortality compared with average third-quarter (summer) death counts. We used linear regression models to assess the relationship between ILI data and mortality, separately for quarters 4 and 1 for each influenza season, and model parameter estimates to predict seasonal mortality counts and calculate excess ILI-associated deaths.Results An estimated 1% absolute increase in quarterly ILI was associated with a 1.5% increase in relative mortality for quarter 4 and a 2.0% increase for quarter 1. The average number of annual deaths potentially attributable to ILI was substantial, about 1100 deaths per year.Conclusions We found an association between community ILI activity and seasonal variation in all-cause mortality in patients with ESRD, with ILI likely contributing to .1000 deaths annually. Surveillance efforts, such as timely reporting to the CDC of ILI activity within dialysis units during influenza season, may help focus attention on high-risk periods for this vulnerable population.

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Section: Discussionmentioning

confidence: 93%

Excess Deaths Attributable to Influenza-Like Illness in the ESRD Population

Gilbertson

Rothman

Chertow

et al. 2019

JASN

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“…hMPV, RSV, together with HPIVs, all belong to the Paramyxoviridae family which is classified as a Pneumovirinae subfamily and a Paramyxovirinae subfamily, and the Paramyxoviridae has nonsegmented, single‐stranded, negative‐sense RNA genomes . Their detection rate is high in ARIs, particularly in infants and children, which indicates their important clinical significance in acute respiratory illness.…”

Section: Discussionmentioning

confidence: 99%

“…More than 200 viruses are major etiological agents of ARIs. Respiratory syncytial virus (RSV), human metapneumoviruses (hMPVs), and human parainfluenza viruses (HPIVs) that are classified into the subfamilies Pneumovirinae and Paramyxovirinae and the Paramyxoviridae has a nonsegmented, single‐stranded, negative‐sense RNA genome, which was the common causative agents of ARIs in humans in all age groups . These viruses can cause acute respiratory diseases such as croup, bronchiolitis, and pneumonia in children, the elderly, and immunodeficiency patients.…”

Section: Introductionmentioning

confidence: 99%

“…HPIVs have four subtypes including HPIV‐1, HPIV‐2, HPIV‐3, and HPIV‐4; HPIV‐4 is considered less important. HPIV‐1, HPIV‐2, and HPIV‐3 are prevalent in acute respiratory infections in children under 5 years and may account for 17% of hospitalizations . RSV, hMPV, and HPIV infections can cause fever, cough, hypoxia, and severe symptoms such as bronchiolitis and pneumonia .…”

Section: Introductionmentioning

confidence: 99%

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Detection of six common human paramyxoviruses in patients with acute febrile respiratory symptoms using a novel multiplex real‐time RT‐PCR assay

Liu

Niu

Zhao³

et al. 2018

Journal of Medical Virology

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Human metapneumovirus (hMPV), respiratory syncytial virus type A (RSV‐A), RSV‐B, and human parainfluenza viruses 1, 2, and 3 (HPIV‐1, HPIV‐2, and HPIV‐3) are common respiratory paramyxoviruses. Here, we developed a two‐tube triplex one‐step real‐time reverse‐transcription polymerase chain reaction (real‐time RT‐PCR) and evaluated its performance using clinical samples. The data showed that this novel assay was 100% consistent with the monoplex real‐time RT‐PCR assay (in‐house), which was superior to the commercial routine multiplex‐ligation‐NAT‐based assay. Meanwhile, the clinical nasopharyngeal swabs of 471 patients with the acute febrile respiratory syndrome (AFRS) were analyzed using the established method. The results showed that 52 (11.7%) cases were positive for paramyxovirus. Among them, HPIVs and RSV‐A had the highest detection rate. The age and seasonal distribution of human paramyxovirus infection were analyzed. In conclusion, we developed a novel multiplex real‐time RT‐PCR assay for the rapid detection of six common human paramyxoviruses, which were dominant in patients with AFRS in Qinghai.

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“…HPIV1 and 2 are the leading cause of croup in young children and HPIV3 is associated with bronchiolitis, bronchitis, and pneumonia (1). These infections have also been associated with the development or exacerbation of asthma and chronic airway disorders (2). Additionally, HPIVs are the etiological agent of 7% of hospitalized pneumonia cases in children in the U.S. (3), as well as in Africa and Asia (4).…”

Section: Introductionmentioning

confidence: 99%

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

Genoyer

Kulej

Hung

et al. 2020

Preprint

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31Paramyxoviruses are negative sense single-stranded RNA viruses that comprise many important 32 human and animal pathogens, including human parainfluenza viruses. These viruses bud from 33 the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is 34 transported from the cytoplasm to the cell membrane via The viral proteins that are critical for mediating this important initial step in viral assembly are 36 unknown. Here we use the model paramyxovirus, murine parainfluenza virus 1, or Sendai virus 37 (SeV), to investigate the roles of viral proteins in Rab11a-driven virion assembly. We previously 38 reported that infection with SeV containing high levels of copy-back defective viral genomes 39 (DVGs) generates heterogenous populations of cells. Cells enriched in full-length virus produce 40 viral particles containing standard or defective viral genomes, while cells enriched in DVGs do 41 not, despite high levels of defective viral genome replication. Here we take advantage of this 42 heterogenous cell phenotype to identify proteins that mediate interaction of vRNPs with Rab11a. 43We examine the role of matrix protein and nucleoprotein and determine that they are not 44 sufficient to drive interaction of vRNPs with recycling endosomes. Using a combination of mass 45 spectrometry and comparative protein abundance and localization in DVG-and FL-high cells, 46we identify viral polymerase complex components L and, specifically, its cofactor C proteins as 47Paramyxoviruses are single-stranded negative sense RNA viruses that include viruses of 65 clinical and global health significance, such as human parainfluenza viruses (HPIV). HPIV1 and 66 2 are the leading cause of croup in young children and HPIV3 is associated with bronchiolitis, 67 bronchitis, and pneumonia (1). These infections have also been associated with the development 68 or exacerbation of asthma and chronic airway disorders (2). Additionally, HPIVs are the 69 etiological agent of 7% of hospitalized pneumonia cases in children in the U.S. (3), as well as in 70Africa and Asia (4). Although HPIVs pose a significant health burden, there are no direct acting 71 antivirals or preventative vaccines. In order to identify targets for antiviral development, there is 72 a need to better understand fundamental aspects of paramyxovirus biology, including 73 mechanisms of virion assembly and particle production. 74Sendai virus (SeV), or murine parainfluenza virus 1, is closely related to human 75 parainfluenza viruses 1 and 3 with 69% homology at the RNA level between SeV and HPIV1. 76SeV has long served as a well-established model for understanding paramyxovirus replication. 77SeV genome replication occurs in the cytoplasm of infected cells (5) and virions bud from the 78 plasma membrane. The viral genomes are tightly coated in the viral nucleocapsid protein (NP) 79 with one NP molecule for every six nucleotides of genome (6). This viral RNA-protein complex 80 is referred to as the viral ribonucleoprotein (vRNP) (7, 8). Viral genomes a...

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The Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract

Cited by 64 publications

References 64 publications

Excess Deaths Attributable to Influenza-Like Illness in the ESRD Population

Excess Deaths Attributable to Influenza-Like Illness in the ESRD Population

Detection of six common human paramyxoviruses in patients with acute febrile respiratory symptoms using a novel multiplex real‐time RT‐PCR assay

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

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