The Role of Human Platelet Membrane Receptors in Inflammation

McGregor, John L.

doi:10.1016/b978-012390120-0/50006-x

Cited by 5 publications

(4 citation statements)

References 127 publications

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“…The dense granules contain ADP, ATP, serotonin, and calcium ions, whereas the so-called ␣-granules, the most numerous, contain vasoactive components and different proteins, such as the F4 (antiheparinoid), platelet-derived growth factor (PDGF), transforming growth factor ␤ (TGF-␤), ␤-thromboglobulin (␤-TG), fibrinogen, clotting factors V and VIII, and adhesive proteins (McGregor, 1995).…”

Section: Plateletsmentioning

confidence: 99%

Are thrombocytes and platelets true phagocytes?

Meseguer¹,

Esteban²,

Rodrı́guez³

2002

Microscopy Res & Technique

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Thrombocytes and platelets, beyond their primary function in hemostasis, seem to play an active role in inflammation. As regards their phagocytic ability, the results to date are confusing, incomplete, and somewhat contradictory. Whereas the interaction of avian thrombocytes or mammalian platelets with bacteria both in vitro and in vivo has received wide attention, almost no information exists on the topic in "lower" vertebrates. The aim of this work is to review the available information on the phagocytic properties of thrombocytes and platelets. Particular attention is payed to the ontogeny of these cells, the soluble factors involved in the inflammatory process derived from them, and their interaction with particulate material, mainly with bacteria.

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Section: Plateletsmentioning

confidence: 99%

Are thrombocytes and platelets true phagocytes?

Meseguer¹,

Esteban²,

Rodrı́guez³

2002

Microscopy Res & Technique

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“…Activation of platelets by thrombin or calcium ionophore results in loss of membrane asymmetry and expression of PS and/or lysoPS on their cell surface, which is provided to catalyze hemostatic plug formation and blood coagulation (27,28). In the tissue repair process, circulating platelets rapidly adhere to the subendothelial connective tissue exposed by vascular injury.…”

Section: N Erve Growth Factor (Ngf)mentioning

confidence: 99%

“…In the tissue repair process, circulating platelets rapidly adhere to the subendothelial connective tissue exposed by vascular injury. Following this event, attached platelets are activated by a perivascular matrix (27,28). Activated platelets most likely provide the phospholipid molecules at the affected sites.…”

Section: N Erve Growth Factor (Ngf)mentioning

confidence: 99%

Nerve Growth Factor Activates Mast Cells Through the Collaborative Interaction with Lysophosphatidylserine Expressed on the Membrane Surface of Activated Platelets

Kawamoto

Aoki

Tanaka

et al. 2002

The Journal of Immunology

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Effect of nerve growth factor (NGF) on platelet-associated mast cell activation was investigated. Although neither NGF alone nor platelets alone induced significant 5-hydroxytriptamine (5-HT) release from rat peritoneal mast cells, marked 5-HT release was detected when costimulated with NGF and calcium ionophore-activated platelets. This response reached maximal levels as early as 5 min after the initiation of the coincubation and was completely blocked by anti-NGF Ab or by an inhibitor for a tyrosine kinase of the trkA NGF receptor. Paraformaldehyde-fixed platelets activated with either calcium ionophore or thrombin exhibited the collaborative ability, suggesting the possible involvement of some membrane molecules expressed on activated platelets in mast cell activation. Because activation of platelets induced expression of phosphatidylserine (PS) and/or lysoPS on membrane surface, and since lysoPS, unlike PS, initiated the NGF-induced 5-HT release, lysoPS expressed on activated platelets may be involved in the mast cell activation. Moreover, intradermal injection of NGF and activated platelets into the rat skin increased local vascular permeability. These findings suggested that NGF collaboratively worked with membrane lysoPS of activated platelets to induce mast cell activation. Thus, NGF released in response to inflammatory stimuli may contribute to mast cell activation in collaboration with locally activated platelets in the process of inflammations and tissue repair.

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“…It had become clear by 1995 that platelets also play major roles in inflammation and immunity [ 12 - 15 ]. This concept was amply confirmed and extended by subsequent findings [ 16 ], beginning with the discovery around the same time of the first chemokine receptor on platelets (referenced below).…”

Section: Introduction To Platelets As Inflammatory Mediatorsmentioning

confidence: 99%

Role of platelets in neuroinflammation: a wide-angle perspective

Horstman

Ahn

et al. 2010

J Neuroinflammation

101

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ObjectivesThis review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.OrganizationAfter a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.ConclusionThe final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.

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The Role of Human Platelet Membrane Receptors in Inflammation

Cited by 5 publications

References 127 publications

Are thrombocytes and platelets true phagocytes?

Are thrombocytes and platelets true phagocytes?

Nerve Growth Factor Activates Mast Cells Through the Collaborative Interaction with Lysophosphatidylserine Expressed on the Membrane Surface of Activated Platelets

Role of platelets in neuroinflammation: a wide-angle perspective

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