The Role of Hyaluronic Acid in Atherosclerosis and Intimal Hyperplasia

Sadowitz, Benjamin; Seymour, Keri A.; Gahtan, Vivian; Maier, Kristopher G.

doi:10.1016/j.jss.2011.09.025

Cited by 42 publications

(33 citation statements)

References 92 publications

(153 reference statements)

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“…The link between HA and atherosclerosis mentioned previously [35] is interesting given that atherosclerosis is regarded as one of the major risk factors for dementia [36]. In addition, neuropathologic examinations have revealed atherosclerosis in patients with AD and VaD [37,38].…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia

Nägga

Hansson

Westen

et al. 2014

JAD

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Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as a clinical diagnostic biomarker to identify vascular pathology in dementia, we analyzed the levels of HA in the CSF of patients with vascular dementia (VaD) (n = 46), AD (n = 45), and controls without dementia (n = 26). In line with our previous data, we found significantly increased levels of HA in CSF from patients with VaD compared with controls, whereas the levels of HA in patients with AD were found to be unaltered compared with controls and patients with VaD. We also detected increased levels of HA in individuals with vascular changes determined as significant white matter changes or previous infarction on cranial computed tomography or magnetic resonance imaging, compared with individuals without these findings. Furthermore, we found a significant positive correlation between the levels of HA and the CSF/serum albumin ratio, an indicator of blood-brain barrier integrity, in patients with VaD and AD, supporting the role of HA in vascular changes in the brain. Our results indicate a potential diagnostic value for the detection of vascular brain changes in dementia using CSF levels of HA, but emphasize the importance of further development of more sensitive HA assays.

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Section: Discussionmentioning

confidence: 99%

Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia

Nägga

Hansson

Westen

et al. 2014

JAD

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“…Using a VSMC culture model, it was found that Pg ‐LPS could upregulate the proliferation of VSMCs, which was the same finding as in previous research about the effect of LPS on VSMCs 26 , 27 . As is known, upregulation of VSMC proliferation leads to neointima formation, which results in arteriosclerosis and restenosis after vascular injury 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis Lipopolysaccharide Stimulation of Vascular Smooth Muscle Cells Activates Proliferation and Calcification

Liu

Deng

Zhang

et al. 2016

Journal of Periodontology

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“…HA is composed of repeating GlcNAc and D-glucuronic acid (GlcUA) units (1,3,4) linked via an alternating ␤-1,4-and ␤-1,3-glycosidic bonds (5,6). Under physiological conditions, the molecular mass and concentration of HA in synovial fluid are between 2150 and 4960 kDa and less than 4 mg/ml, respectively (3,7).…”

Section: Hyaluronan (Ha)mentioning

confidence: 99%

Chemically Modified N-Acylated Hyaluronan Fragments Modulate Proinflammatory Cytokine Production by Stimulated Human Macrophages

Babasola

Rees-Milton

Bebe

et al. 2014

Journal of Biological Chemistry

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Background: Low molecular mass hyaluronan (LMHA) is proinflammatory, but the role of the N-acetyl moieties is unknown. Results: Chemical reacetylation of LMHA results in maximal proinflammatory cytokine production by human macrophages, compared with other N-acylations. Partial N-butyrylation blocks cytokine stimulation. Conclusion:The N-acetyl moieties of glucosamine are critical for LMHA proinflammatory properties. Significance: N-Acetylation and butyrylation of LMHA modulate proinflammatory cytokine production.

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The Role of Hyaluronic Acid in Atherosclerosis and Intimal Hyperplasia

Cited by 42 publications

References 92 publications

Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia

Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia

Porphyromonas gingivalis Lipopolysaccharide Stimulation of Vascular Smooth Muscle Cells Activates Proliferation and Calcification

Chemically Modified N-Acylated Hyaluronan Fragments Modulate Proinflammatory Cytokine Production by Stimulated Human Macrophages

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