The role of hydrogen sulfide regulation of pyroptosis in different pathological processes

Zhang, Yanting; Zhao, Huijie; Fu, Xiaodi; Wang, Kexiao; Yang, Jiahao; Zhang, Xinyuan; Wang, Honggang

doi:10.1016/j.ejmech.2024.116254

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116254

|View full text |Cite

The role of hydrogen sulfide regulation of pyroptosis in different pathological processes

Yanting Zhang,

Huijie Zhao,

Xiaodi Fu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway

Zhou,

Zheng,

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway

Zhou,

Zheng,

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

Liu,

Li,

Zhou

et al. 2024

Neural Regeneration Research

View full text Add to dashboard Cite

It has been reported that the PI3K/AKT signaling pathway plays a key role In the pathogenesis of ischemic stroke. As a result, the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers. This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke, with a focus on the PI3K/AKT signaling pathway. The key findings include the following: (1) The complex pathological mechanisms of ischemic stroke can be categorized into five major types: excitatory amino acid toxicity, Ca2+ overload, inflammatory response, oxidative stress, and apoptosis. (2) The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke, which primarily involves the NF-kB, NRF2, BCL-2, mTOR, and endothelial NOS signaling pathways. (3) Natural products, including flavonoids, quinones, alkaloids, phenylpropanoids, phenols, terpenoids, and iridoids, show great potential as candidate substances for the development of innovative anti-stroke medications. (4) Recently, novel therapeutic techniques, such as electroacupuncture and mesenchymal stem cell therapy, have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway, providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke. Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The role of hydrogen sulfide regulation of pyroptosis in different pathological processes

Cited by 2 publications

References 126 publications

Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway

Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway

PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

Contact Info

Product

Resources

About